A5078869149- Pharmacological Effects of Natural Compounds
- Malaria Research and Control
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Computational Drug Discovery Methods
- Phytochemistry and Biological Activities
- Synthesis and biological activity
- Essential Oils and Antimicrobial Activity
- Synthesis and Characterization of Heterocyclic Compounds
- Phytochemistry and Bioactivity Studies
- Microbial Natural Products and Biosynthesis
- Insect Pest Control Strategies
- Pharmacological Effects of Medicinal Plants
- Ethnobotanical and Medicinal Plants Studies
- Crystallization and Solubility Studies
- Sesquiterpenes and Asteraceae Studies
- Herbal Medicine Research Studies
- X-ray Diffraction in Crystallography
- Cancer Treatment and Pharmacology
- Plant biochemistry and biosynthesis
- Quinazolinone synthesis and applications
- Synthesis and Biological Evaluation
- Bioactive natural compounds
- Phytochemical Studies and Bioactivities
- Phytochemistry and biological activity of medicinal plants
Central Institute of Medicinal and Aromatic Plants
2014-2024
Academy of Scientific and Innovative Research
2015-2024
University of Lucknow
2014-2018
National Bureau of Plant Genetic Resources
2018
Agricultural Research Organization
2018
University of Florida
1996-1998
The antimalarial drug artemisinin from Artemisia annua demonstrated remarkably strong activity against Helicobacter pylori, the pathogen responsible for peptic ulcer diseases. In an effort to develop a novel antimicrobial chemotherapeutic agent containing such sesquiterpene lactone endoperoxide, series of analogues (2 natural and 15 semisynthetic molecules), including eight newly synthesized compounds, were investigated clinical standard strains H. pylori. spectrum 10 pylori few other...
Isoliquiritigenin (ISL) and liquiritigenin (LTG) are structurally related flavonoids found in a variety of plants. Discovery novel antimicrobial combinations for combating methicillin-resistant Staphylococcus aureus (MRSA) infections is vital importance the post-antibiotic era. The present study was taken to explore vitro vivo combination effect LTG ISL with β-lactam antibiotics (penicillin, ampicillin oxacillin) against mec A-containing strains MRSA. Minimum inhibitory concentration (MIC)...
Novel artemisinin-1,2,3-triazole derivatives show significant antiproliferative activity, and induce apoptosis ROS generation arrest the cell cycle at G2/M phase.
To screen the active antimalarial novel artemisinin derivatives, a QSAR modeling approach was used. model showed high correlation (r(2)= 0.83 and rCV(2)= 0.81) indicated that Connectivity Index (order 1, standard), 2, Dipole Moment (debye), Vector X (debye) LUMO Energy (eV) well correlate with activity. High binding likeness on target plasmepsin detected through molecular docking. Active derivatives significant activity compliance standard parameters of oral bioavailability ADMET. The...
Malaria is an enormous threat to public health due the emergence of Plasmodium falciparum resistance widely used anti-malarials, such as chloroquine.
A rapid and simple high-performance thin-layer chromatographic (HPTLC) method has been developed for the simultaneous quantitative estimation of biologically active diterpenoids, 14-deoxy-11,12-didehydroandrographolide, andrographolide, neoandrographolide andrographiside in Andrographis paniculata. The assay combines isolation separation andrographolide derivatives on silica gel 60 F254 HPTLC plates with spot visualization scanning at 540 nm. Methanol was found to be most appropriate solvent...
The present investigation shows that certain substituted chalcone derivatives diminish the escalation of bacterial cells<italic>via</italic>inhibiting efflux pump and exhibit a synergistic interaction with norfloxacin.
Oleo–gum–resin of Boswellia serrata Roxb. (Burseraceae) was collected from Shivpuri forest situated in northwestern district Madhya Pradesh, India. The commercial samples were purchased Mandsaur and Neemuch districts (the major herbal markets Pradesh) for comparative study their essential oils. average oil contents the (11.1%) much better as compared to wild collection (6.1%) well (6.9%). contained higher percentage monoterpene hydrocarbons (81.9–88.1%) including α-thujene (61.4–69.8%)...
Abstract Artemisia annua (Asteraceae) is well known for its antimalarial activities due to presence of the compound artemisinin. We isolated a methoxy coumarin from stem part A. and confirmed identity as scopoletin through mass spectral data. The structure was established 1H-nuclear magnetic resonance (NMR), 13C-NMR. evaluated feeding deterrence growth inhibitory potential against noxious lepidopteran insect, Spilartctia obliqua Walker. Scopoletin gave FD50 (feeding 50%) value 96.7 μg/g diet...
Cerebral malaria is a serious and sometimes fatal disease caused by a<italic>Plasmodium falciparum</italic>parasite that infects female anopheles mosquito which feeds on humans.
A series of twenty one chalcone derivatives having indole moiety were synthesized and evaluated against four human cancer cell lines. Indolyl chalcones 1a, 1b, 1d, 1f-1j, 2c, 2e, 2i showed good anticancer activity. Chalcones 1b 1d the most active selective agents with IC50 values <1μg/ml 1.51μg/ml, WRL-68 line, respectively. Molecular mechanism was explored through in silico docking & ADMET studies. Keywords: 1, 3-Diaryl-2-propen-1-ones, Anticancer agents, chalcones.
Malaria control is hindered by drug-resistant parasites, leading to a shortage of effective drugs. There need find new, better antimalarial drug. Traditional Chinese Medicine (TCM) are more accessible and cheaper alternative for combating resistance in the treatment malaria, therefore anti-malarial efficacy root extracts isolated phytomolecules from Glycyrrhiza glabra L was assessed. The anti-plasmodial potential L. assessed using Giemsa staining method. In- vivo, evaluated conducting...
Artemisia annua (Asterales: Asteraceae) is one of the important natural sources antimalarial compounds i.e., artemisinin and artemisinic acid. Also this plant cultivated on a large area in India under industry-farmer partnerships. With view to enhance added value raw material A. its chemical constituents, we evaluated methanolic extract powdered leaves different isolated from for toxicity inhibition disruption growth development African pod borer, Helicoverpa armigera (Hübner) (Lepidoptera:...
This work presents the development of quantitative structure activity relationship (QSAR) model to predict antimalarial artemisinin derivatives. The structures molecules are represented by chemical descriptors that encode topological, geometric, and electronic features. Screening through QSAR suggested compounds A24, A24a, A53, A54, A62 A64 possess significant activity. Linear is developed multiple linear regression method link their reported correlation in terms coefficient (r2) was 0.90...