A5077443822- Fatty Acid Research and Health
- Connexins and lens biology
- Glutathione Transferases and Polymorphisms
- Carcinogens and Genotoxicity Assessment
- Metabolomics and Mass Spectrometry Studies
- Sulfur Compounds in Biology
- Advanced Glycation End Products research
- Diet and metabolism studies
- Per- and polyfluoroalkyl substances research
- Eicosanoids and Hypertension Pharmacology
- Lipid metabolism and biosynthesis
- Toxic Organic Pollutants Impact
- Machine Learning in Healthcare
- Family and Disability Support Research
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Genomics, phytochemicals, and oxidative stress
- Nutritional Studies and Diet
- Developmental Biology and Gene Regulation
- Antioxidant Activity and Oxidative Stress
- Corneal Surgery and Treatments
- Birth, Development, and Health
- Ocular Disorders and Treatments
- Ethics in Clinical Research
- Renal and related cancers
Yale University
2019-2024
Michigan State University
2016-2017
New York University
1990
Columbia University
1990
Vitamin E uptake by Caco-2 cells, a human intestinal cell line, was studied incubating the cells with alpha-tocopherol/triglyceride emulsions or without bile activated lipase lipoprotein lipase. During 1-h incubation, vitamin transferred to only in presence of triglyceride hydrolysis and not Incubation either resulted approximately 20% medium [3H]-triolein free fatty acids 3-5-fold increase cellular radioactivity. In absence lipases but taurocholate, addition oleic acid an amount equal molar...
Abstract Over the last century, outbreaks and pandemics have occurred with disturbing regularity, necessitating advance preparation large-scale, coordinated response. Here, we developed a machine learning predictive model of disease severity length hospitalization for COVID-19, which can be utilized as platform future unknown viral outbreaks. We combined untargeted metabolomics on plasma data obtained from COVID-19 patients (n = 111) during healthy controls 342), clinical comorbidity 508) to...
Delta-5 (D5D) and delta-6 (D6D) desaturase are key enzymes in fatty acid (FA) metabolism. Dietary eicosapentaenoic (EPA) docosahexaenoic (DHA) may alter tissue FA composition via D5D D6D. The purpose was to determine the relationship between dietary EPA + DHA, estimated activities of various tissues reflection activity red blood cell (RBC). Mice were fed diets with increasing percent energy from DHA. Phospholipid heart, muscle, spleen, lung, adipose RBC analysed. D6D enzyme estimates (EAE)...
Despite widespread global use of artificial turf fields, there is a paucity research assessing the presence potentially harmful chemicals within field components.This pilot study aimed to assess capacity an adapted extraction-analysis method identify and quantitate FTOHs, class perfluoroalkyl polyfluoroalkyl substances (PFAS), in fiber crumb rubber infill samples.FTOHs fibers were extracted using 80:20 methanol:methyl tert-butyl ether, reconstituted methanol, analyzed by gas...
Delta‐5‐desaturase (D5D) and delta‐6‐desaturase (D6D) are critical in polyunsaturated fatty acid (PUFA) metabolism. D5D D6D catalyze the conversion of linoleic (LA) into arachidonic (AA) that alpha‐linolenic (ALA) eicosapentaenoic (EPA). Altered PUFA desaturation (i.e., increased decreased D5D) can exacerbate inflammatory responses. Supplementation with long chain PUFAs (LCPUFAs) EPA DHA influence metabolism decrease pro‐inflammatory Furthermore, changes activity associated obesity, type‐2...
In recent decades, special attention has been given to the privacy and discrimination risks associated with genetic information. Federal, state, international laws all contain specific protections for use of information in a variety contexts, including insurance employment. Yet very considerations motivating extend beyond mere genetics. Epigenetics involves study heritable changes gene function that do not involve DNA sequence. Epigenetic data shares number normative similarities policy...
Reduced glutathione (GSH) is an abundant antioxidant that regulates intracellular redox homeostasis by scavenging reactive oxygen species (ROS). Glutamate-cysteine ligase catalytic (GCLC) subunit the rate-limiting step in GSH biosynthesis. Using
Abstract Glutamate cysteine ligase catalytic subunit (Gclc) is the for glutamate-cysteine (Gcl) enzyme. Gcl catalyzes rate limiting step in glutathione (GSH) synthesis. Gclc highly expressed developing eye. To define regulatory role of eye development, we developed a novel, Le-Cre transgene-driven, knockout mouse model. f/f / Tg/− mice present with deformation retina, cornea, iris, and lens, consistent microphthalmia phenotype. Controlling phenotype wt/wt revealed that have more severe Thus,...
BACKGROUND AND AIMS: Epidemiological and experimental evidence suggests that exposure to per- polyfluoroalkyl substances (PFAS) increases risk of type 2 diabetes (T2D). However, the mechanisms linking PFAS T2D remain unclear. We examined whether alters insulin secretion in adolescents. METHODS: Overweight/obese adolescents (n=124 female, n=167 males; baseline age: 11.3±1.7 years) from Study Latinos at Risk (SOLAR) underwent annual clinical visits. Acute response glucose (AIRg; indicates...
Abstract Recent reports have challenged the notion that lens is immune-privileged. However, these studies not fully identified molecular mechanism(s) promote immune surveillance of lens. Using a mouse model targeted glutathione (GSH) deficiency in ocular surface tissues, we investigated role oxidative stress upregulating cytokine expression and promoting eye. RNA-sequencing lenses from postnatal day (P) 1- aged Gclc f/f ;Le-Cre Tg/− (KO) −/− control (CON) mice revealed upregulation many...