A5102851623- Pancreatic and Hepatic Oncology Research
- Multiple Myeloma Research and Treatments
- Osteoarthritis Treatment and Mechanisms
- Spine and Intervertebral Disc Pathology
- Neuroendocrine Tumor Research Advances
- Robot Manipulation and Learning
- Orthopedic Surgery and Rehabilitation
- Bone fractures and treatments
- Bone and Joint Diseases
- Cervical and Thoracic Myelopathy
- Elbow and Forearm Trauma Treatment
- Protein Degradation and Inhibitors
- Spinal Fractures and Fixation Techniques
- Phytochemical compounds biological activities
- Natural Compounds in Disease Treatment
- Hydraulic and Pneumatic Systems
- Robotic Locomotion and Control
- Advanced Sensor and Control Systems
- Human Pose and Action Recognition
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- Cell Adhesion Molecules Research
- Amyotrophic Lateral Sclerosis Research
- Human Motion and Animation
- Microtubule and mitosis dynamics
First Affiliated Hospital of Xiamen University
2022-2024
Ruijin Hospital
2018-2023
Shanghai Jiao Tong University
2018-2023
Third Affiliated Hospital of Sun Yat-sen University
2018-2023
Sun Yat-sen University
2018-2023
Sir Run Run Shaw Hospital
2014-2020
Zhejiang University
2014-2020
Blood Center of Zhejiang Province
2020
Tongren Hospital
2020
Tiangong University
2018
In Brief Study Design. This study investigated the expression of 2 types ADAMTS in human intervertebral cartilage endplate (CEP) and related mechanisms concerning tumor necrosis factor α (TNF-α)–induced nuclear κB signaling pathway. Objective. To determine which type is more strongly expressed role TNF-α CEP. Summary Background Data. ADAMTS-4 ADAMTS-5 were proven to be essential degeneration articular disc. CEP an important structure adjacent However, activities are unclear. Methods. CEPs...
This study aimed to measure apparent diffusion coefficient (ADC) in Chinese patients with newly diagnosed multiple myeloma by whole-body diffusion-weighted magnetic resonance imaging (WB-DWI MRI) and assess the diagnostic accuracy of ADC discrimination deep response induction chemotherapy.Seventeen underwent WB-DWI MRI before after chemotherapy (week 20). DWI images maps were produced 89 regions interest chosen. percent changes compared between (complete or very good partial response)...
Precisely imitating human motions in real-time poses a challenge for the robots due to difference their physical structures. This paper proposes human-computer interaction method remotely manipulating life-size humanoid with new metrics evaluating motion similarity. First, we establish capture system acquire operator's data and retarget it standard bone model. Secondly, develop fast mapping algorithm, by BVH (BioVision Hierarchy) collected each joint angle of robot realize imitated control...
Amyotrophic lateral sclerosis (ALS) is a progressive and lethal neurodegenerative disease. Several studies have suggested the involvement of cuproptosis in its pathogenesis. In this research, we intend to explore cuproptosis-related molecular clusters ALS develop novel genes prediction model.
With a catalytic amount of Rh(cod)2 BF4 and dppm, cyclopropenes undergo direct carbonylative [3+1] cycloaddition reaction under an atmosphere CO to produce the cyclobutenones in excellent yields, which regio- diastereoselectivities can be controlled certain cases with help chelating groups. Cyclobutenone chiral 4-position was prepared by diastereoselective induction. Rhodacyclopentenone has been determined as key intermediate, it synthesized applied reductive elimination step.
Diabetes mellitus (DM) is a potential etiology of disc degeneration. N-cadherin (N-CDH) helps maintain the cell viability, phenotype and matrix biosynthesis nucleus pulposus (NP) cells. Here, we mainly aimed to investigate whether N-CDH can attenuate high glucose-induced NP senescence its mechanism.Rat cells were cultured in base culture medium with 0.2 M glucose concentration. Recombinant lentiviral vectors used enhance expression Senescence-associated β-galactosidase (SA-β-Gal) activity...
Postoperative pancreatic fistula (POPF) is a major source of morbidity after pancreaticoduodenectomy (PD). The purpose this retrospective study comparing one-layer pancreaticojejunostomy (PJ) with two-layer PJ PD was to evaluate whether the duct-to-mucosa can reduce incidence POPF.A total 194 consecutive patients who underwent by one surgeon (Y. Miao) from January 2011 February 2014 were included in study. Among those patients, 104 (one-layer group) and 90 (two-layer group), respectively....
SPAG5, as a spindle-associated protein in mitosis, has been observed to have oncogenic activities solid tumors. Here, we identified that SPAG5 expression was correlated with the deterioration of plasma cell malignancy and overexpression (OE) predicted unfavorable outcomes multiple myeloma (MM). knockdown led anti-MM effects MM lines animal xenograft models by regulating growth apoptosis. Furthermore, gene set enrichment analysis (GSEA) revealed PI3K/AKT/mTOR pathway enriched samples highly...
Background: Osteoarthritis (OA) is a degenerative joint disease that seriously affects the quality of people. Unfortunately, pathogenesis OA has not been fully known. Therefore, this study aimed to construct ceRNA regulatory network related explore OA. Methods: Differentially expressed circRNAs (DEcircRNAs), microRNAs (DEmiRNAs), and mRNAs (DEmRNAs) were obtained from Gene Expression Omnibus microarray data (GSE175959, GSE105027, GSE169077). The miRNA response elements target identified...
Knee osteoarthritis (KOA) is one of the most commonly encountered degenerative diseases joints in people over 45 years age. Currently, there are not any effective therapeutics for KOA,and only end-point strategy total knee arthroplasty (TKA); therefore, KOA associated with economic burdens and societal costs. The immune inflammatory response involved occurrence development KOA. We previously established a mouse model using type II collagen. Hyperplasia synovial tissue was present model,...
Inspired by the concept of Tri-Co Robots, a real-time motion imitation based human-robot interaction method is proposed to telemanipulate life-size humanoid robot. First, capture system established retarget accurate data skeletal model. Second, transfer for human-in-the-loop control realized through publish-subscribe messaging mechanism in ROS (Robot Operating System). Third, fast mapping algorithm developed convert BVH (BioVision Hierarchy) into corresponding joint angles which are then...
Purpose This paper aims to present a human-in-the-loop natural teaching paradigm based on scene-motion cross-modal perception, which facilitates the manipulation intelligence and robot teleoperation. Design/methodology/approach The proposed is used telemanipulate life-size humanoid in response complicated working scenario. First, vision sensor project mission scenes onto virtual reality glasses for reactions. Second, motion capture system established retarget eye-body synergic movements...
Objective: Multiple myeloma (MM) remains incurable with high rates of relapse. New therapeutic drugs are therefore urgently needed to improve the prognosis. JaponiconeA (JA), a natural product isolated from Inula japonica Thunb, has shown good anti-MM potential. A comprehensive study should be conducted identify both in vitro and vivo mechanisms effects JA. Methods: CCK8 assays flow cytometry were used detect proliferation, apoptosis, cell cycle MM lines when treated In experiments using...
Due to the increasing demand for safe human-robot or environment-robot interaction, development of intrinsically compliant actuators becomes a key issue robotic design. However, introduction compliance in an actuation system will increase oscillations and reduce mechanical bandwidth making difficult control. In order solve such problems, this paper proposes novel Variable Viscous Damping Actuator (VVDA) which has hydraulic transmission unit placed parallel with series elastic element. The...
To compare the clinical value between locating radial nerve (RN) guided by Color Doppler ultrasonography and posterior antebrachial cutaneous (PACN) in humeral approach.The five fresh adult cadavers (ten upper arms) were selected to two methods of RN approach (guided ultrasound PACN) measuring operation time, length incision, area subcutaneous free. And comparison groups was statistically analyzed paired t-test.The results this study demonstrated that incision free group smaller than PACN (P...
Abstract Background Volar locked plate for distal radius fracture is one of the common procedures performed in trauma surgery. There are already some factors which can be used to predict functional outcome after volar plating fracture. However their limitations caused that outcomes couldn’t satisfactorily predicted. Better predicting prognosis more precisely great interest. The aim this study introduce such a new factor. Methods A total 56 patients suffered from unilateral were managed...