A5100368077- Biomarkers in Disease Mechanisms
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Spinal Cord Injury Research
- Circular RNAs in diseases
- Sirtuins and Resveratrol in Medicine
- Apelin-related biomedical research
- Nutrition and Health in Aging
- Genetics and Neurodevelopmental Disorders
- Venous Thromboembolism Diagnosis and Management
- Higher Education and Teaching Methods
- Cardiovascular Function and Risk Factors
- Acute Kidney Injury Research
- Dermatological and Skeletal Disorders
- Bacterial Infections and Vaccines
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Nutritional Studies and Diet
- Chemotherapy-induced cardiotoxicity and mitigation
- Viral Infections and Immunology Research
- Neonatal and Maternal Infections
- Effects of Radiation Exposure
- Advanced Sensor and Energy Harvesting Materials
- Adipokines, Inflammation, and Metabolic Diseases
- Nerve injury and regeneration
Qilu Hospital of Shandong University
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2022
First Affiliated Hospital of Xi'an Jiaotong University
2020-2021
Shanxi Medical University
2019
Second Hospital of Shanxi Medical University
2019
Hainan Medical University
2018
First Hospital of China Medical University
2012
China Medical University
2012
Cardiac hypertrophy is an adaptive response to pressure, volume stress, and loss of contractile mass from prior infarction. Metabolic changes in cardiac include suppression fatty acid oxidation enhancement glucose utilization, which could result lipid accumulation the heart. SIRT3, a mitochondrial NAD+-dependent deacetylase, has been demonstrated play crucial role controlling acetylation status many enzymes participating energy metabolism. However, SIRT3 pathogenesis hypertrophy-related...
Emerging evidence indicates that irisin provides beneficial effects in diabetes. However, whether influences the development of diabetic cardiomyopathy (DCM) remains unclear. Therefore, we investigated potential role and mechanism action diabetes-induced myocardial dysfunction mice. Type 1 diabetes was induced mice by injecting streptozotocin, were administered recombinant r-irisin (low or high dose: 0.5 1.5 μg/g body weight/day, I.P.) PBS for 16 weeks. Irisin treatment did not alter blood...
Spinal cord injury is characterized by high incidence and disability, the specific targets drugs have not yet been explored. Lipid droplet a type of organelles that regulates lipid metabolism oxidative stress. And regulatory mechanisms droplets on spinal remain unclear. Herein, it found GTPase activation Annexin A7 (ANXA7) promotes up-regulation genes related to formation. ANXA7 can interact with peroxisome proliferator-activated receptor gamma (PPARγ) enhance stability PPARγ, promote...
To explore the clinical characteristics and etiology of bacterial meningitis (BM) in Chinese children.BM cases children 28days to 18 years old were collected from January 2014-December 2016 screened according World Health Organization standards. Clinical features, pathogens, resistance patterns analyzed.Overall, 837 classified into five age groups: 28 days-2 months (17.0%), 3-11 (27.8%), 12-35 (24.0%), 3-6 (13.9%), >6years (17.3%). Major pathogens Streptococcus pneumoniae (S. pneumoniae,...
Context: Sunitinib (SU) is a multi-targeted tyrosine kinase inhibitor anticancer agent whose clinical use often limited by cardiovascular complications. Trimetazidine (TMZ) an anti-angina that has been demonstrated cardioprotective effects in numerous conditions, but its potential SU-induced cardiotoxicity have not investigated. Objective: This study investigates the effect of TMZ sunitinib-induced vivo and vitro molecular mechanisms. Materials methods: Male 129S1/SvImJ mice were treated...
Spinal cord injury (SCI) could lead to severe disabilities in motor and sensory functions, cause a heavy burden on patient physiology psychology due lack of specific repair measures so far. ANXA7 is an annexin with Ca2+ -dependent GTPase activity, which were mainly expressed neuron spinal downregulated significantly after SCI mice. In our study, activity activation plays the protective role OGD/R through inhibiting apoptosis, mediated by enhancing autophagy via mTOR/TFEB pathway. We also...
Biomarkers for early diagnosis of hepatocellular carcinoma (HCC) are needed in chronic hepatitis B virus (HBV) infection, a leading cause HCC. We evaluated whether measurement serum pentraxin 3 (PTX3) could improve HCC HBV infection. Data from patients with HBV-related (n = 159), cirrhosis 99) and 107), healthy controls 151) were analyzed. Serum PTX3 concentration was measured by immunoassay. Area under the receiver operating characteristic curve (AUC) applied to assess diagnostic accuracy....
Hepatocellular carcinoma (HCC) is a major cause of liver-related mortality. Serum pentraxin 3 (PTX3) has been revealed to be associated with the development hepatitis B virus (HBV)-related HCC. This study evaluated whether serum PTX3 related survival HBV-related HCC patients.One hundred and seven patients were included. Baseline levels quantified using quantitative immunoassay. The followed-up for median 24 months divided into high level low groups according baseline levels. overall...
Dystrophic epidermolysis bullosa (DEB) is an incurable and inherited skin disorder mainly caused by mutations in the gene encoding type VII collagen (COL7A1). The purpose of this study was to identify causative genetic variants further perform diagnosis a Chinese family affected DEB.High-throughput sequencing performed analyze disorder-related genes parents proband, were confirmed other members Sanger sequencing. sequencing, karyotype analysis, chromosomal microarray analysis (CMA) used...
In order to analyze the effect of EV71 vaccination on incidence encephalitis in patients with HFMD, 292 cases were vaccinated, and 2,486 not vaccinated which collected 2018 2019. It shows that rate was significantly lower than non-vaccinated (P = .028), suggests vaccine has a protective occurrence encephalitis. But some still developed into showed they had produced protection or weak against EV71-related encephalitis; reasons require further investigation.
Objective. To explore the effects of systematic diet education combined with multidisciplinary nursing on nutritional status and calcium phosphorus metabolism in patients diabetic kidney disease (DKD) uremic phase after treatment alogliptin. Methods. A total 90 DKD uremia admitted to our hospital from January 2020 2021 were selected as research objects. The subjects divided into group routine by random number table method. All received alogliptin medication. combination dietary medication,...
Abstract Calcification is common in atherosclerotic plaque and can induce vulnerability, which further leads to myocardial infarction, rupture stroke. The mechanisms of calcification are poorly characterized. Interleukin enhancer binding factor 3 (ILF3) has been identified as a novel affecting dyslipidemia stroke subtypes. However, the precise role ILF3 remains unclear. Here we showed that expression increased calcified human aortic vascular smooth muscle cells (HAVSMCs) humans mice. We then...
Background: Intellectual disability (ID) is defined by cognitive and social adaptation defects. Variants in the SYNGAP1 gene, which encodes brain-specific cytoplasmic protein SYNGAP1, are commonly associated with ID. The aim of this study was to identify novel gene variants Chinese individuals ID evaluate pathogenicity detected variants. Methods: Whole exome sequencing (WES) performed on 113 patients diagnosed In study, two de novo were identified. Sanger used confirm these Minigene assays...
Objective To evaluate the diagnostic value of 99Tcm-tetrofosmin(TF) stress-rest MPI in detecting CHD.Methods Eighty patients with suspected CHD who had from October 2009 to April 2011 were retrospectively analyzed.Forty underwent 99Tcm-TF (group A) and 40 received ~Tcm-MIBI B) MPI.Heart/lung (H/L) ratios these two groups compared.CAG was performed on group A 3 months before after MPI.Stenosis more than 50％ CAG used as a standard efficiency MPI.Paired t test x2 compare data.Results H/L rest...
Objective To explore the predictive value of serum PTX-3 level in acute exacerbation chronic obstructive pulmonary disease (COPD) by mensurating levels patients with COPD different stage and healthy people, to provide a new method for judging patients. Methods Ninety exacerbations who was hospitalized department respiratory medicine, Chengde Central Hospital, 90 stable admitted outpatient, normal persons physical examination Hospital from January 2016 December were included this...
Objective: To define the effect of PM2.5 exposure on NF- κ B signaling pathway and airway inflammation, to reveal role K in inflammation induced by atmospheric rats. Air pollution condition plays an important inflammatory response process. Previous studies had suggested that was a common environmental problem, influencing almost 98% Southeast Asian populations. Therefore, study its mechanism is great significance. Methods: Atmospheric from urban traffic trunk roads collected prepared into...
The development of world English makes contemporary teaching generate the transformation paradigm, while, cross-cultural teaching, as one important targets in is also facing a new problem and challenge.It impossible to meet students' exchange demands only by mastering British American cultural knowledge.The belief comprehension college teachers on key teaching.This study used combination questionnaire focus group interview further teaching.Contemporary have sufficient cognition importance...
In recent years, studies have shown that GABA has a certain therapeutic effect on acute lung injury (ALI), but its specific mechanism not been fully elucidated. The study was designed to investigate the protective and of γ-aminobutyric acid (GABA) ALI induced by lipopolysaccharide (LPS) in mice.C57BL/6 mice were randomly divided into control group, LPS + (10 mg/kg) group dexamethasone (Dex, 5 group. survival rate each observed at different time points after modeling. levels tumor necrosis...
Compared with non-diabetic patients, patients type 2 diabetes mellitus have two to four times increased risk of macrovascular diseases whose pathological basis is atherosclerosis. Risk factors atherosclerosis such as obesity, hypertension and dyslipidemia were significantly in the population mellitus(mainly mellitus), resulting a higher prevalence atherosclerosis, earlier onset faster disease progression mellitus. Visceral adipose tissue-derived serine protease inhibitor(vaspin), one...
Abstract Background and Objective: With the increase of aging, osteoporosis cardiovascular diseases are common in middle-aged elderly people. The purpose this study is to explore correlation between osteocalcin coronary calcification.Methods: A total 150 physical examination subjects who had undergone artery CT angiography (CTA) were selected as research objects. calcification score was calculated according Agatston (AS) integral method, divided into group non-calcification group. indexes...