A5102010291- Acupuncture Treatment Research Studies
- Heart Rate Variability and Autonomic Control
- Vagus Nerve Stimulation Research
- Healthcare and Venom Research
- Cardiac Ischemia and Reperfusion
- Autophagy in Disease and Therapy
- Rheumatoid Arthritis Research and Therapies
- Traditional Chinese Medicine Studies
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Heme Oxygenase-1 and Carbon Monoxide
- EEG and Brain-Computer Interfaces
- Pain Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Parasitic infections in humans and animals
- Sesquiterpenes and Asteraceae Studies
- Cardiovascular Syncope and Autonomic Disorders
- Spinal Cord Injury Research
- Neonatal and Maternal Infections
- S100 Proteins and Annexins
- Toxoplasma gondii Research Studies
- Energy and Environmental Systems
- Neurosurgical Procedures and Complications
Anhui University of Traditional Chinese Medicine
2014-2024
Nanjing University of Chinese Medicine
2014-2024
China Association of Acupuncture-Moxibustion
2017-2023
National Institute for Parasitic Diseases
2020-2022
Anhui University
2017-2020
National Patient Safety Foundation
2020
Beth Israel Deaconess Medical Center
2020
Massachusetts Institute of Technology
2020
Center for Disease Control
2020
Tianjin Medical University General Hospital
2020
Astaxanthin (ATX) has been proven to ameliorate early brain injury (EBI) after experimental subarachnoid hemorrhage (SAH) by modulating cerebral oxidative stress. This study was performed assess the effect of ATX on Nrf2-ARE pathway and explore underlying molecular mechanisms antioxidant properties in EBI SAH. A total 96 male SD rats were randomly divided into four groups. Autologous blood injected prechiasmatic cistern rat induce an SAH model. Rats each group sacrificed at 24 h Expressions...
Abstract Background Myocardial ischemia–reperfusion can further exacerbate myocardial injury and increase the risk of death. Our previous research found that paraventricular nucleus (PVN) hypothalamus plays a crucial role in improvement (MIRI) by electroacupuncture (EA) pretreatment, but its mechanism action is still unclear. CRH neurons exhibit periodic concentrated expression PVN, needed to determine whether they are involved MIRI EA pretreatment. Meanwhile, numerous studies have shown...
Abstract During sepsis, platelets dysfunction contributes to organ dysfunction. Studies on in the long-term prognosis of sepsis are lacking. The aim this study was assess role patients. A total 4576 patients were extracted from MIMIC III Database. Survival analyzed by Kaplan-Meier method. Univariate and multivariate cox analyses performed identify prognostic factors. Significant factors combined build a nomogram predict 1 year overall survival (OS). discriminative ability predictive accuracy...
To observe the influence of different moxibustion durations on hypothalamic pro-opiomelanocortin (POMC) and prodynorphin (PDYN) mRNA expressions plasma β-endorphin (β-EP) content in rheumatoid arthritis (RA) rats, to understand mechanism analgesia its dose-effect relationship. Twelve male Wistar rats were randomly selected from 48 as a normal control group. The RA model was created by raising windy (blowing with electric fan), cold (6°C ± 2°C), wet (80%-90% humidity) environment for 20 days,...
A major side effect of reperfusion therapy following myocardial infarction is ischemia-reperfusion injury (MIRI). Electroacupuncture preconditioning (EA-pre) has a long history in the treatment cardiovascular diseases. Here, we demonstrate how EA-pre attenuates MIRI by affecting phagocytosis neuronal dendritic spines microglia fastigial nucleus (FNmicroglia). We observed that increased activity FNGABA and then improved inhibiting abnormal activities glutaminergic neurons FN (FNGlu) during...
Edaravone has been shown to reduce ischemia/reperfusion-induced peripheral nerve injury. However, the therapeutic effect of edaravone on injury caused by mechanical factors is unknown. In present study, we established a model crushing sciatic using hemostatic forceps, and then administered 3 mg/kg intraperitoneally. The functional index superoxide dismutase activity were increased, malondialdehyde level was decreased in animals group compared with those group. Bcl-2 expression but Bax...
Myocardial ischemia-reperfusion injury (MIRI) has high morbidity and mortality worldwide. Increasing evidence shown that electroacupuncture (EA) plays a critical role in alleviating MIRI. The aim of this study is to investigate whether glutamatergic neurons the lateral hypothalamus (LH) have vital effect on MIRI as well underlying mechanism during EA pretreatment. model was established by ligating left anterior descending (LAD) coronary artery for 30 min followed reperfusion 2 h....
Breast cancer resistance protein (ABCG2), a member of the ATP-binding cassette transporters has been identified as major determinant multidrug (MDR) in cells, but ABC transporter inhibition limited therapeutic value vivo. In this research, we demonstrated that efflux ABCG2 induced generation tolerogenic DCs from human peripheral blood myeloid (mDCs). expression was present mDCs and further increased by LPS stimulation. Treatment CD1c+ with an inhibitor, Ko143, during stimulation caused...
Myocardial ischemia reperfusion injury (MIRI) is an important mechanism of post-myocardial infarction and a main cause death in patients with ischemic heart disease. Electroacupuncture (EA) pretreatment effective for the prevention treatment MIRI, but mechanisms mediating effects cardiovascular disease EA treatments remain unclear.To determine whether lateral hypothalamus (LHA) cerebellar fastigial nucleus (FN) are involved protective stimulation on MIRI.EA was performed 7 days before...
To observe the effects of electroacupuncture (EA) pretreatment on cardiac function, sympathetic nerve activity, indexes myocardial injury and GABAA receptor in fastigial nucleus rats with ischemia reperfusion (MIRI), to explore neuroregulatory mechanism EA improving MIRI.A total 60 male SD were randomly divided into a sham operation group, model an agonist group agonist+EA 12 each group. The MIRI was established by ligation left anterior descending coronary artery. applied at bilateral...
Despite very different functions, studies increasingly report that there may be a potential central nervous anatomical connection between the heart and small intestine. In this study, relationship intestine was studied via viral tracer. Pseudorabies virus (PRV) syngeneic strains with fluorescent reporter genes (eGFP or mRFP) were microinjected into walls intestinal of male C57BL/6J using glass microelectrode. The results showed co-labeled nuclei in brain lateral periaqueductal gray (LPAG)...
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Abstract Accumulating evidence suggests that electroacupuncture (EA) has obvious therapeutic effects and unique advantages in alleviating myocardial ischemia–reperfusion injury (MIRI), while the underlying neuromolecular mechanisms of EA intervention for MIRI have not been fully elucidated. The aim study is to investigate role neural pathway hypothalamic paraventricular nucleus (PVN) neurons projecting rostral ventrolateral medulla (RVLM) alleviation rats by preconditioning. models were...
<title>Abstract</title> Electroacupuncture (EA) has been shown to suppress premature ventricular complexes (PVCs) following myocardial infarction (MI) in humans. However, the specific neural circuitry and causal mechanisms underlying this effect remain unclear. Here, we reveal a previously unrecognized connection from primary motor cortex (M1) nucleus rostral ventrolateral medulla (RVLM) via layer 5 of (M1L5)-zona incerta (ZI) pathway, which selectively suppresses PVCs post-MI mice....