A5043549166- Reproductive Physiology in Livestock
- Rabbits: Nutrition, Reproduction, Health
- Regulation of Appetite and Obesity
- Apelin-related biomedical research
- Reproductive Biology and Fertility
- Adipose Tissue and Metabolism
- Sperm and Testicular Function
- Adipokines, Inflammation, and Metabolic Diseases
- Veterinary Medicine and Surgery
- Hypothalamic control of reproductive hormones
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Diet, Metabolism, and Disease
- Reproductive System and Pregnancy
- Lipid metabolism and disorders
- Ovarian function and disorders
- Fatty Acid Research and Health
- Herpesvirus Infections and Treatments
- Endometriosis Research and Treatment
- Animal Nutrition and Physiology
- Hormonal Regulation and Hypertension
- melanin and skin pigmentation
- Growth Hormone and Insulin-like Growth Factors
- Estrogen and related hormone effects
- Neuroendocrine regulation and behavior
- Cannabis and Cannabinoid Research
University of Perugia
2016-2025
Institute of Agricultural Biology and Biotechnology
2011
University of Bologna
1994
To investigate the ovulatory mechanisms triggered by raw semen (RS) in rabbits, we examined expression of nerve growth factor (NGF)—a supposed ovulation-inducing (OIF)—and cognate receptors anterior pituitary, ovary, and cervix as well plasma NGF luteinizing hormone (LH) concentrations. Six does/group were sham-inseminated with sterile saline (PBS), naturally mated (NM), inseminated RS alone or after lumbar anesthesia (ARS), treatment COX inhibitors (CIRS). Immunohistochemistry revealed...
Ghrelin (GhRL) is an orexigenic hormone influenced by nutritional state. It plays a role in skin repair and diseases, though little information exists regarding its function this organ. GhRL receptor were investigated the of sheep under different feeding conditions to explore system presence possible modifications due diet. Three-year-old female free graze from June pasture maximum flowering (MxF group) period dryness addicted (Exp or not (MxD with 600 gr/die/head barley corn. Skin samples...
Nerve growth factor (NGF) plays a critical role in reproduction through paracrine and endocrine mechanisms. However, its autocrine effects on uterine receptivity inflammatory pathways remain unknown. This study is the first to demonstrate NGF's direct action sheep endometrial luminal epithelial cells (SELECs), primary cultures treated with NGF for 12, 24, 48 h, or without NTRK1 antagonist. significantly increased PGE2 (p < 0.0001) PGF2α levels only at 12 no significant changes 24 h. also...
Aging involves progressive physiological changes, including the dysregulation of water homeostasis, essential for cellular function, neuronal signaling, and musculoskeletal integrity. This review explores emerging role loss as a central underestimated driver functional decline in aging, with focus on dog, both clinically relevant target species model human aging. Age-related alterations metabolism—driven by changes body composition, aquaporin (AQP) expression, electrolyte imbalances, reduced...
The effects of components aqueous licorice root extract (LE) on the pharmacokinetics glycyrrhizin (G) and glycyrrhetic acid (GA) were investigated in rats humans. aim this work was to define role G toxicity. In procedure, GA detected biological fluids by means recently improved HPLC methods. Significantly lower plasma levels found humans treated with LE compared obtained those which alone administered. pharmacokinetic curves showed significant differences areas under plasma-time curve (AUC),...
Contents Experiments were devised to characterize the expression of nerve growth factor, beta polypeptide ( NGF ), and its cognate receptors neurotrophic tyrosine kinase receptor type 1 NTRK 1) factor NGFR ) in rabbit male sex organs, as well concentrations both seminal blood plasma sexually mature rabbits. Immunoreactivity gene for detected testis, prostate gland vesicle. The highest levels transcripts found prostate, while intermediate expressions testis. expressed at same testis more...
Resveratrol is one of the most investigated natural polyphenolic compounds and contained in more than 70 types plants red wine. The widespread interest this polyphenol derives from its antioxidant, anti-inflammatory anti-aging properties. Several studies have established that resveratrol regulates animal reproduction. However, mechanisms action potential therapeutic effects are still unclear. This review aims to clarify role male female reproductive functions, with a focus on animals...
Sheep are the most bred species in Central Italy Apennine using natural pastures as a trophic resource and grazing activity is fundamental to maintain grassland biodiversity: this goal can be reached only ensuring an economical sustainability farmers. This study aimed investigate apelin/apelin receptor system ovine mammary gland evaluate differences induced by food supplementation, order shed light on function. A flock of 15 Comisana x Appenninica adult dry ewes were free graze from June...
Resistin (RETN), a recently discovered adipokine, is cysteine-rich and secretory protein produced by adipocytes. RETN has been detected in several tissues, including human laboratory animals' pancreas, wherein impairs glucose tolerance insulin (INS) action causes INS resistance. This study aims to evaluate the presence expression of pancreas 15 adult female sheep reared on Apennine pastures, which show decrease their nutritional value due drought stress linked increasing summer aridity. The...
MiRNA-based therapies represent an innovative and promising strategy applicable to various medical fields, such as tissue regeneration the treatment of numerous diseases, including cancer, cardiovascular problems, viral infections. MiRNAs, a group small non-coding RNAs, play critical role in regulating gene expression at post-transcriptional level modulate several signaling pathways that maintain cellular homeostasis. The clinical trials discussed review herald new therapeutic era for...
The expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and its role in corpora lutea (CL) function were studied pseudopregnant rabbits. Corpora collected at an early stage (Day 4), midstage 9), late 13) pseudopregnancy. Immunohistochemistry found evidence for the presence PPARgamma perinuclear cytoplasm nucleus all luteal cells; immunoreactivity decreased from to stage, with immunonegativity nuclei CL. mRNA transcript was expressed stages lowest level stage. In CL...
The potential antiviral effects of indole-3-carbinol (I3C), a phytochemical found in Cruciferous vegetables, were investigated. Fibroblasts and epithelial cells co-cultured on Alvetex® scaffolds, to obtain ad hoc 3D vitro platforms able mimic the trachea intestinal mucosae, which represent primary structures involved coronavirus pathogenesis. two barriers generated treated with various concentrations I3C for different incubation periods. A protective effect both models was demonstrated....
The objective of the present study was to investigate in rabbit corpora lutea (CL), at both cellular and molecular level, intraluteal cyclooxygenase (COX)-1, COX-2 prostaglandin (PG) E2-9-ketoreductase (PGE2-9-K) enzymatic activities as well vitro PGE2 PGF2α synthesis following treatment either early- (day-4) or mid-luteal (day-9) stage pseudopregnancy. By immunohistochemistry, positive staining for localized luteal endothelial cells stromal arteries stages. In CL stages, basal mRNA levels...
The expression of type I GNRH receptor (GNRHR-I) and the direct role GNRH-I on corpora lutea (CL) function were studied in pseudopregnant rabbit model. Immunohistochemistry evidenced GNRHR-I luteal cells at early (day 4 pseudopregnancy)-, mid 9)-, late 13)-luteal stages. Real-time RT-PCR western blotting revealed mRNA protein three Buserelin vivo treatment days 9 13 decreased plasma progesterone levels for 48 24 h respectively. In vitro cultured CL, buserelin reduced secretion, increased...