A5066353377- Rabbits: Nutrition, Reproduction, Health
- Apelin-related biomedical research
- Sperm and Testicular Function
- Animal Nutrition and Physiology
- Adipose Tissue and Metabolism
- Mycobacterium research and diagnosis
- Hypothalamic control of reproductive hormones
- Plant Reproductive Biology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Ginseng Biological Effects and Applications
- Reproductive Biology and Fertility
- Neuropeptides and Animal Physiology
- CRISPR and Genetic Engineering
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Diet, Metabolism, and Disease
- Nerve injury and regeneration
- Fatty Acid Research and Health
- Plant Molecular Biology Research
- RNA and protein synthesis mechanisms
- Reproductive biology and impacts on aquatic species
- Heavy metals in environment
- PARP inhibition in cancer therapy
- Gynecological conditions and treatments
- Mechanical Systems and Engineering
- Signaling Pathways in Disease
Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche
2019-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2023
University of Trento
2022
University of Perugia
2017-2020
Universitat Politècnica de València
2020
Università di Camerino
2015-2020
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2012
Abstract Pediatric and adult high-grade gliomas are the most common primary malignant brain tumors, with poor prognosis due to recurrence tumor infiltration after therapy. Quiescent cells have been implicated in treatment resistance, but their direct visualization targeting remain challenging, precluding mechanistic study. Here, we identify a population of expressing Prominin-1 non-proliferating state pediatric glioma patients. Using genetic tool visualize ablate quiescent mouse cancer human...
To investigate the ovulatory mechanisms triggered by raw semen (RS) in rabbits, we examined expression of nerve growth factor (NGF)—a supposed ovulation-inducing (OIF)—and cognate receptors anterior pituitary, ovary, and cervix as well plasma NGF luteinizing hormone (LH) concentrations. Six does/group were sham-inseminated with sterile saline (PBS), naturally mated (NM), inseminated RS alone or after lumbar anesthesia (ARS), treatment COX inhibitors (CIRS). Immunohistochemistry revealed...
This study evaluated heavy metal levels (Pb, Cd, Hg, As, Cu) and the presence of Salmonella spp. Listeria monocytogenes in mussels commonly consumed fishery products from Marmara region Türkiye. Health risks were using total hazard quotient (THQ) index (HI) values, while microbial fresh ready-to-eat (RTE) estimated via Risk Ranger tool. Among 625 samples, Hg (36.96%; CI95 = 33.27–48.81), Pb (9.76%; 7.67–12.34), Cd (19.36%; 16.45–22.64) exceeded permissible limits, except crabs, which...
LAGLIDADG homing endonucleases (LHEs) are DNA cleaving enzymes, also termed 'meganucleases' that employed as gene-targeting reagents. This use of LHEs requires their specificity be altered to match sequences in genomic targets. The choice the most appropriate LHE target a particular gene is facilitated by growing number such enzymes with well-characterized activities and structures. 'LAHEDES' (The Homing Endonuclease Database Engineering Server) provides both an online archive validated...
Contents Experiments were devised to characterize the expression of nerve growth factor, beta polypeptide ( NGF ), and its cognate receptors neurotrophic tyrosine kinase receptor type 1 NTRK 1) factor NGFR ) in rabbit male sex organs, as well concentrations both seminal blood plasma sexually mature rabbits. Immunoreactivity gene for detected testis, prostate gland vesicle. The highest levels transcripts found prostate, while intermediate expressions testis. expressed at same testis more...
Sheep are the most bred species in Central Italy Apennine using natural pastures as a trophic resource and grazing activity is fundamental to maintain grassland biodiversity: this goal can be reached only ensuring an economical sustainability farmers. This study aimed investigate apelin/apelin receptor system ovine mammary gland evaluate differences induced by food supplementation, order shed light on function. A flock of 15 Comisana x Appenninica adult dry ewes were free graze from June...
Standard feeds are imbalanced in term of n-6/n-3 polyunsaturated fatty acids (PUFA) ratio, with a low proportion the latter. The reproductive system appears to be strongly affected by administration n-3 PUFA, and ingredients rich α-linolenic acid (ALA; i.e. vegetable sources) or EPA DHA (i.e. fish oil) can included animal diets balance PUFA intake. aim this study was evaluate effect dietary supplementation flaxseed (ALA) oil (EPA DHA) on metabolism rabbit does. A total 60 New Zealand White...
Abstract Kisspeptin (KiSS) and its related receptors (KiSS1R) have a critical role in the reproduction of mammals. The KiSS/KiSS1R system is expressed numerous reproductive organs including ovary. Here, we studied expression functional rabbit corpora lutea (CL) at days 4 (early-), 9 (mid-), 13 (late-stage) pseudopregnancy. In vitro progesterone, prostaglandin (PG) F2α (PGF2α) E2 (PGE2) productions prostaglandin-endoperoxide synthase 1 (PTGS1) 2 (PTGS2) activities were evaluated. Immune...
Mycobacterium avium ssp. paratuberculosis (MAP) is the causative agent of (PTB), a widespread chronic enteritis ruminants. The progression infection depends on containment action innate and cell-mediated immunity (CMI), it related to environmental genetic factors. In particular, PTB susceptibility seems be associated with specific genes coding for immune regulators involved in response during infection. aim this preliminary study was verify, Italian beef cattle, an association between MAP...
Resistin is a polypeptide hormone of the adipokine-family, primarily, but not exclusively, produced by adipose tissue. Recent studies suggested that resistin may affect male and female reproductive activity. The study aim was to immunohistochemically evaluate presence distribution in ovine uterus. Uterine samples were collected from two groups ewes at end an experimental trial during which animals first group (CTRL) fed only grazing while those second one (EXP) supplemented with barley corn....
Paratuberculosis (PTB), also known as Johne's disease, is a chronic proliferative enteritis of ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP). To date, PTB diagnosis, based on serology, fecal culture, and real-time polymerase chain reaction, has identified animals in advanced stages infection. detect MAP infection earlier, the interferon-gamma (IFN-γ) test may be applied. This assay detects cytokines produced T-lymphocytes infected subjects after stimulation with...
In order to determine whether a combination of guaiphenesin, ketamine and xylazine can induce safe satisfactory anaesthesia in mules undergoing field castration, eight healthy adult intact male were employed. They premedicated with intravenous (IV) (1.3 mg/kg); an additional dose (0.3 mg/kg IV) was administered case inadequate depth sedation. Anaesthesia induced IV thiopental (6 mg/kg). The quality sedation induction recorded. maintained infusion guaiphenesin (50 mg/mL), (2 mg/mL) (1 (GKX)....
Tuberculins purified protein derivatives (PPDs) are obtained by precipitation from heat treated mycobacteria. PPDs used in diagnosis of mycobacterial infections humans and animals. Bovine PPD (PPDB) is Mycobacterium bovis (Mycobacterium tuberculosis complex), while Avian (PPDA) Johnin (PPDJ) extracted, respectively, avium M. subsp. paratuberculosis (M. complex). PPDB PPDA for bovine diagnosis, PPDJ experimentally the immunodiagnosis paratuberculosis. Although date back to 19th Century,...
Studying human somatic cell-to-neuron conversion using primary brain-derived cells as starting cell source is hampered by limitations and variations in biopsy material. Thus, delineating the molecular variables that allow changing identity of cells, permit adoption neuronal phenotypes, foster maturation induced neurons (iNs) challenging. Based on our previous results pericytes derived from adult cerebral cortex can be directly converted into iNs (Karow et al., 2018; Karow 2012), we here...