A5077236627- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Ginseng Biological Effects and Applications
- Immune Response and Inflammation
- Aquaculture disease management and microbiota
- Antimicrobial Peptides and Activities
- Microbial infections and disease research
- Viral Infectious Diseases and Gene Expression in Insects
- Animal Diversity and Health Studies
- Management, Economics, and Public Policy
- Parasitic Infections and Diagnostics
- Sperm and Testicular Function
- Anaerobic Digestion and Biogas Production
- Reproductive System and Pregnancy
- Diagnosis and treatment of tuberculosis
- Clostridium difficile and Clostridium perfringens research
- Parasitic infections in humans and animals
- Quinazolinone synthesis and applications
- Transgenic Plants and Applications
- Veterinary medicine and infectious diseases
- Galectins and Cancer Biology
- Brucella: diagnosis, epidemiology, treatment
- Complement system in diseases
- Toxin Mechanisms and Immunotoxins
- Gut microbiota and health
Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche
2012-2023
University of Perugia
2018
Bovine tuberculosis (bTB) is an emerging disease among wild animals in many parts of the world. Wildlife reservoir hosts may thus represent a potential source infection for livestock and humans. We investigated role played by Sicilian black pig, autochthonous free- or semi-free-ranging domestic pig breed, as bTB area where prevalence cattle high. initially performed preliminary field study to assess occurrence such animals. sampled 119 pigs at abattoir found 6.7% 3.4% them be affected gross...
Mycobacterium avium ssp. paratuberculosis (MAP) is the causative agent of (PTB), a widespread chronic enteritis ruminants. The progression infection depends on containment action innate and cell-mediated immunity (CMI), it related to environmental genetic factors. In particular, PTB susceptibility seems be associated with specific genes coding for immune regulators involved in response during infection. aim this preliminary study was verify, Italian beef cattle, an association between MAP...
Paratuberculosis (PTB), also known as Johne's disease, is a chronic proliferative enteritis of ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP). To date, PTB diagnosis, based on serology, fecal culture, and real-time polymerase chain reaction, has identified animals in advanced stages infection. detect MAP infection earlier, the interferon-gamma (IFN-γ) test may be applied. This assay detects cytokines produced T-lymphocytes infected subjects after stimulation with...
We report cystic echinococcosis in a free-living wild boar ( Sus scrofa ) Europe. Parasites were identified by histopathology and molecular techniques, revealing Echinococcus granulosus of the G3 genotype.
To evaluate the survival of Mycobacterium avium subsp. paratuberculosis (MAP) during anaerobic digestion (AD), we studied two different biogas plants loaded with manure and slurry from paratuberculosis-infected dairy herds.Both were operating under mesophilic conditions, first a single digester second double digester. detection was performed by sampling each stage process, specifically prefermenter, fermenter, liquid digestate solid stages, for 11 months. In both plants, MAP isolated...
Sertoli cells (SC) are immune privileged with the capacity of modulating response by expressing several immune-regulatory factors. SC have to respond external stimuli through innate phagocytic and antibacterial activities. This evidence evoked a potential role as drug carriers therapeutic agents. Such drive towards still unknown evolution, clinical relevance which yet remains undisclosed. study sought investigate effects in form polymeric microparticles (MP) bacteria derived endotoxins, such...
Tuberculins purified protein derivatives (PPDs) are obtained by precipitation from heat treated mycobacteria. PPDs used in diagnosis of mycobacterial infections humans and animals. Bovine PPD (PPDB) is Mycobacterium bovis (Mycobacterium tuberculosis complex), while Avian (PPDA) Johnin (PPDJ) extracted, respectively, avium M. subsp. paratuberculosis (M. complex). PPDB PPDA for bovine diagnosis, PPDJ experimentally the immunodiagnosis paratuberculosis. Although date back to 19th Century,...
Clostridium perfringens is the causative agent of several diseases and enteric infections in animals humans. The virulence C. largely attributable to production numerous toxins; these, alpha toxin (CPA) plays a crucial role histotoxic (gas gangrene). CPA consists two domains, i.e., phospholipase C active site, which lies N-terminal domain amino acid (aa residues 1-250), C-terminal region 251-370), responsible for interaction with membrane phospholipids presence calcium ions. All currently...
A 40 years old male Nile crocodile (Crocodylus niloticus) was diagnosed with pulmonary mycobacteriosis caused by a member of Mycobacterium chelonae/abscessus group. Post-mortem examination showed severe systemic visceral granulomatous involvement, lesions in lungs, heart, liver, spleen and kidneys. Histopathological lung, spleen, heart liver revealed multifocal to coalescing granulomas showing eterophils central zone outer rim epithelioid histiocytes, multinucleated giant cells lymphocytes....