A5008878552- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Dysphagia Assessment and Management
- Peripheral Artery Disease Management
- Neurosurgical Procedures and Complications
- Tracheal and airway disorders
- Cellular transport and secretion
- Stroke Rehabilitation and Recovery
- Esophageal and GI Pathology
- Voice and Speech Disorders
- Mitochondrial Function and Pathology
- Advanced Fluorescence Microscopy Techniques
- Lysosomal Storage Disorders Research
- Immune cells in cancer
- Radiomics and Machine Learning in Medical Imaging
- 3D Printing in Biomedical Research
- Cerebrospinal fluid and hydrocephalus
- Surgical Simulation and Training
- Barrier Structure and Function Studies
- Bacterial Infections and Vaccines
- Medical Imaging and Analysis
- Intraocular Surgery and Lenses
- Pluripotent Stem Cells Research
Icahn School of Medicine at Mount Sinai
2022-2025
Braxton (United States)
2023-2024
New York Stem Cell Foundation
2024
Mount Sinai Hospital
2023-2024
Allen Institute for Brain Science
2023-2024
Mount Sinai Health System
2022-2023
Stem Cell Institute
2023
Mount Sinai Hospital
2022
Amherst College
2022
Background Appropriate management of spontaneous intracerebral hemorrhage (ICH) and intraventricular (IVH) requires rapid, accurate volume estimation. Viz.AI has developed an artificial intelligence (AI)-powered ICH calculation tool that may improve existing methods. Methods Adult patients presenting to a large healthcare system between December 2015 2021 with greater than 10mL within 72 hours since ictus were analyzed for hematoma volume. mABC/2 (modified ABC/2) was measured by...
Endovascular treatment (EVT) is part of the usual care for proximal vessel occlusion strokes. However, safety and effectiveness EVT distal medium occlusions remain unclear. We sought to compare clinical outcomes medical management (MM) isolated occlusions.
Summary The pathological hallmark of neurodegenerative disease is the aberrant post-translational modification and aggregation proteins leading to formation insoluble protein inclusions. Genetic factors like APOE4 are known increase prevalence severity tau, amyloid, α-Synuclein However, human brain largely inaccessible during this process, limiting our mechanistic understanding. Here, we developed an iPSC-based 3D model that integrates neurons, glia, myelin, cerebrovascular cells into a...
Background Minimally invasive evacuation may help ameliorate outcomes after intracerebral hemorrhage (ICH). However, hospital length of stay (LOS) post-evacuation is often long and costly. Objective To examine factors associated with LOS in a large cohort patients who underwent minimally endoscopic evacuation. Methods Patients presenting to health system spontaneous supratentorial ICH qualified for if they met the following inclusion criteria: age ≥18, premorbid modified Rankin Scale (mRS)...
We explored the clinical significance of residual hematoma cavity 1 year after minimally invasive intracerebral hemorrhage (ICH) evacuation.Patients presenting with spontaneous supratentorial ICH were evaluated for surgical evacuation. Inclusion criteria included age ≥18 years, preoperative volume (Hv) ≥15 mL, National Institutes Health Stroke Scale score ≥6, and premorbid modified Rankin (mRS) ≤3. Patients longitudinal CT scans at least 3 months evacuation in study. Remnant volumes (Cv)...
Introduction: The impact of intracerebral hemorrhage (ICH) and timing surgical evacuation on brain cell types is poorly understood. Here, we identify type specific responses to blood exposure in an organoid model ICH using single transcriptomics. Methods: Human organoids consisting excitatory/inhibitory neurons, neural progenitor cells (NPC), astrocytes, pericytes, microglia were generated from induced pluripotent stem treated with 5% for 6 or 24 hours. Organoids dissociated sequenced...
Background: The optimal anesthesia modality during endovascular treatment (EVT) for distal medium vessel occlusion (DMVO) strokes is uncertain. We aimed to evaluate the impact of on procedural and clinical outcomes following EVT DMVO strokes. Methods: This a retrospective analysis prospectively collected database from 14 comprehensive stroke centers in United States Europe. Patients were included if they had due MCA-M3/4, ACA-A1/A2-3, or PCA-P1/P2-3 underwent EVT. cohort was divided into two...
Background: The use of balloon guide catheter (BGC) has been associated with better reperfusion and clinical outcomes in mechanical thrombectomy (MT) for large vessel occlusion strokes (LVOS). association between BGC angiographic patients distal medium (DMVO) undergoing MT not investigated. Methods: This is a retrospective analysis prospectively collected database from 14 comprehensive stroke centers the United States Europe. Patients were included if they had anterior circulation DMVO due...
Cellular processes including lysosomal and mitochondrial dysfunction are implicated in the development of many diseases. Quantitative visualization mitochondria lysosoesl is crucial to understand how these organelles dysregulated during disease. To address a gap live-imaging tools, we developed GEM-SCOPe (Genetically Encoded Modular SubCellular Organelle Probes), modular toolbox fluorescent markers designed inform on localization, distribution, turnover, oxidative stress specific organelles....
Background The optimal anesthesia modality during endovascular treatment (EVT) for distal medium vessel occlusion (DMVO) stroke is uncertain. We aimed to evaluate the association of with procedural and clinical outcomes following EVT DMVO stroke. Methods This a multicenter retrospective analysis prospectively collected database. Patients were included if they had involving middle cerebral artery-M3/4, anterior artery-A2/3, or posterior artery-P1/P2-3, underwent EVT. cohort was divided into...
Introduction: Treatment of spontaneous intracerebral hemorrhage (ICH) requires rapid, accurate estimation volume to determine appropriate patient care and guide prognosis. ICH on Computed Tomography (CT) imaging using the ABC/2 formula is clinical gold standard, however this method can be inaccurate, suffers from observer scoring variability, takes time make measurement a workstation. Semi-Autonomous Segmentation (SAS) standard for estimation, it not used clinically due increased analysis....
The blood-brain barrier (BBB) is a key physiological component of the central nervous system (CNS), maintaining nutrients, clearing waste, and protecting brain from pathogens. inherent properties BBB pose challenge for therapeutic drug delivery into CNS to treat neurological diseases. Impaired function has been related disease. Cerebral amyloid angiopathy (CAA), deposition in cerebral vasculature leading compromised BBB, co-morbidity most cases Alzheimer's disease (AD), suggesting that...
Introduction: Dysphagia is a common complication among acute ischemic stroke (AIS) patients and associated with increased mortality morbidity. A complete understanding of the characteristics who present dysphagia after AIS warranted. Objective: To identify risk factors outcomes presenting over twenty years. Methods: query 2000-2019 National Inpatient Sample was performed for admitted (ICD9 433, 43401, 43411, 43491, ICD-10 I63). Demographics, comorbidities, were identified. Univariate...
Introduction: Lower cranial nerve motor dysfunction is a well-distinguished feature in acute ischemic stroke (AIS). As result, patients can present with vocal dysfunction, including fold paralysis (VFP). Few studies have examined VFP AIS patients. Objective: To identify the incidence and characteristics of presenting after AIS. Methods: A query 2000-2019 National Inpatient Sample was performed for admitted (ICD9 433, 43401, 43411, 43491, ICD-10 I63). Demographics, comorbidities, outcomes...