A5115603640- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Retinal Imaging and Analysis
- Genomics and Phylogenetic Studies
- Mosquito-borne diseases and control
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Circular RNAs in diseases
- Bacteriophages and microbial interactions
- Cancer Mechanisms and Therapy
- Organoboron and organosilicon chemistry
- DNA and Biological Computing
- Cancer-related molecular mechanisms research
- Chromatin Remodeling and Cancer
- Asymmetric Hydrogenation and Catalysis
- Caching and Content Delivery
- Protein Degradation and Inhibitors
- Pulsed Power Technology Applications
- Genomics and Rare Diseases
- Glaucoma and retinal disorders
- Advanced Synthetic Organic Chemistry
Sichuan University
2018-2025
West China Hospital of Sichuan University
2018-2025
Jingchu University of Technology
2025
Nanjing Medical University
2020-2024
Shantou University
2024
Nankai University
2024
Colorado State University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Zhejiang University
2024
Wuhan University
2024
Genomic studies have demonstrated a high frequency of genetic alterations in components the SWI/SNF complex including core subunit SMARCA4. However, mechanisms tumorigenesis driven by SMARCA4 mutations, particularly colorectal cancer (CRC), remain largely unknown. In this study, we identified specific, hotspot mutation (c. 3721C>T) which results conversion from arginine to tryptophan at residue 1157 (R1157W) human CRC tissues associated with higher-grade tumors and controls progression....
Differentiating between Alzheimer's disease (AD) and frontotemporal dementia (FTD) can be challenging due to overlapping cognitive behavioral manifestations. Evidence regarding non-invasive early-stage biomarkers remains limited. Our aim was identify retinal for the risk of AD FTD in populations without explore underlying brain structural mechanisms. We included a total 3,0573 UK Biobank participants dementia, ocular disorders, diabetes who underwent baseline optical coherence tomography...
Chemotherapeutic drug/gene nanoparticles (NPs) co-delivery system has great potential in tumor therapy. However, the role of circular RNA (circRNA) cerebellar degeneration-related 1 (CDR1) (circCDR1) and temozolomide (TMZ) NPs treatment glioma remains unclear. circCDR1 was significantly low expressed tissues cells. In term mechanism, could sponge miR-890 to regulate GJB6. The inhibition on progression be reversed by miR-890, suppressive effect inhibitor also overturned GJB6 silencing. CNPs...
Abstract Background Lysine methyltransferase 2D (KMT2D) mediates mono‐methylation of histone H3 lysine 4 (H3K4me1) in mammals. H3K4me1 mark is involved establishing an active chromatin structure to promote gene transcription. However, the precise molecular mechanism underlying KMT2D‐mediated modulates expression triple‐negative breast cancer (TNBC) progression unresolved. Methods and Results We recognized Y‐box‐binding protein 1 (YBX1) as a “reader” mark, point mutation YBX1 (E121A)...
BET inhibition has been shown to have a promising antitumor effect in multiple tumors. However, the impact of on immunity was still not well documented HNSCC. In this study, we aim assess functional role and clarify its mechanism. We show that BRD4 is highly expressed HNSCC inversely correlated with infiltration CD8+ T cells. potentiates cell-based vitro vivo. Mechanistically, acts as transcriptional suppressor represses expression MHC class I molecules by recruiting G9a. Pharmacological or...
Comprehensive Summary Herein, a method for the enantioselective reduction of unprotected 2‐alkylpyridines is reported first time. By using pinacolborane and an amide as reducing agents, large number 2‐alkylpiperidines were synthesized with high yields excellent enantioselectivities via cascade process involving 1,4‐hydroboration subsequent transfer hydrogenation. The resulting products can be easily converted to natural alkaloids.
DNA sequence and structure design is very important for nanoapplications. A computer-aided tool needed exploring of interests before experimental synthesis, which a time- labor-consuming process. In this paper, an interactive software called shop proposed implemented. The visualization can generate structures by specifying, selecting, moving sequences around display corresponding structures. Using the tool, be visually inspected in three-dimensional space studies.
Population genetics of species living in marginal habitats could be particularly informative about the adaptation, but such analyses have not been readily feasible until recently. Sonneratia alba, a mangrove widely distributed Indo-West Pacific, provides very suitable system for study local adaptation. In this study, we analyzed DNA variation by pooling 71 genes from 85–100 individuals sequencing. For each two nearby S. alba populations, obtained ∼2,500 × coverage on Illumina GA platform and...
Abstract Mono‐methylation of histone H3 on Lys 4 (H3K4me1), which is catalyzed by histone‐lysine N‐methyltransferase 2D (KMT2D), serves as an important epigenetic regulator in transcriptional control. In this study, the authors identify early B‐cell factor 2 (EBF2) a binding protein H3K4me1. Combining analyses RNA‐seq and ChIP‐seq data, further killin (KLLN) target KMT2D EBF2 pancreatic ductal adenocarcinoma (PDAC) cells. KMT2D‐dependent H3K4me1 are predominantly over‐lapped proximal to...
DNA computation is to use molecules for information storing and processing. The task accomplished by encoding interpreting in suspended solutions before after the complementary binding reactions. attractive, due its fast parallel processing, remarkable energy efficiency, high capacity. Challenges currently faced are: 1) lack of theoretical computational models applications 2) error rate implementation. This paper attempts address these problems from mathematical modeling genetic coding...
The pituitary tumor-transforming gene 1 (PTTG1) is an oncogene involved in chromosomal segregation, DNA repair, apoptosis, and metabolism.PTTG1 can be used for clinical diagnosis treatment a potential target oropharyngeal carcinoma.The proliferation viability of Cal27 FaDu cells were assessed using the CCK-8 assay.Real-time PCR western blotting, respectively, to analyze mRNA protein expression levels PTTG1 IFIH1.The interaction between translational regulatory IFIH1 was analyzed RNA...
The algorithm of tracking and localizing a single rapid moving sound target, based on double five-elements-cross arrays, is presented in this paper. four time-delay-difference values each array can be estimated by the methods generalized cross-correlation. And then, azimuth angle calculated with special structure array. distance between target center theory, however, satisfactory estimating precision need high accuracy time delay, very difficult. Therefore, acceptable position parameter...
HAPPY mapping was designed to pursue the analysis of approximately random HAPloid DNA breakage samples using PolYmerase chain reaction for genomes.In present study, we improved method and integrated two other molecular techniques into process: whole genome amplification Sequenom SNP (single nucleotide polymorphism) genotyping assay in order facilitate X. tropicalis.The former technique amplified enough materials genotype a large number markers, while latter allowed relatively high throughput...
AIM: To study the effect of NLRP3/autophagy pathway on photoreceptor inflammatory response and protective mechanism CY-09 astaxanthin (AST). METHODS: ICR mice were intraperitoneally injected NaIO3, CY-09, AST successively divided into 5 groups, including control, NaIO3+CY-09, NaIO3+AST, NaIO3+CY-09+AST groups. Spectral domain optical coherence tomography flash electroretinogram examined retina tissues harvested for immunohistochemistry, enzyme linked immunosorbent assay (ELISA), Western...
Background: To estimate the associations of stroke risk with plasma metabolites, metabolic score (MRS), combinations MRS hypertension or lifestyle, and lifestyle-related signature. assess improvement prediction model through incorporation MRS. Methods: A total 77,315 participants from UK Biobank were included in this study. Xgboost LASSO-Cox regression used to select metabolites construct Elastic net was utilized Multivariate Cox between MRS, signature, risk. Results: We identified 48, 63,...
<title>Abstract</title> Background Emerging evidence has revealed that PKM2 oncogenic functions independent of its canonical pyruvate kinase activity, serving as a protein regulates gene expression. However, the mechanism by which PKM2, histone kinase, transcription genes involved in triple-negative breast cancer (TNBC) metastasis remains poorly understood. Methods We integrated cellular analysis, including cell viability, proliferation, colony formation, and migration assays; biochemical...