A5102734475- Nanoplatforms for cancer theranostics
- Gastrointestinal Tumor Research and Treatment
- Photodynamic Therapy Research Studies
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Gastrointestinal Bleeding Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Relativity and Gravitational Theory
- COVID-19 Clinical Research Studies
- Atomic and Subatomic Physics Research
- Molten salt chemistry and electrochemical processes
- Colorectal Cancer Treatments and Studies
- Mechanics and Biomechanics Studies
- Melanoma and MAPK Pathways
- Potassium and Related Disorders
- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Astrophysical Phenomena and Observations
- Porphyrin and Phthalocyanine Chemistry
- COVID-19 and healthcare impacts
- Peptidase Inhibition and Analysis
Tokyo National Hospital
2025
Japan Atomic Energy Agency
2024
Nagoya City University
2022-2024
Mizuho (Japan)
2022-2024
Kasugai Municipal Hospital
2018-2023
Weatherford College
2022
The Nisshin OilliO Group (Japan)
2000
Iwate Medical University
2000
Iwate University
1997
Patients with cancer and health care workers (HCWs) are at high risk of SARS-CoV-2 infection. Assessing the antibody status patients HCWs can help understand spread COVID-19 in care.To evaluate serum during pandemic Japan.Participants were enrolled for this prospective cross-sectional study between August 3 October 30, 2020, from 2 comprehensive centers epidemic area around Tokyo, Japan. aged 16 years or older employees enrolled. Participants suspected infection time enrollment...
Photodynamic therapy (PDT) is a relatively non-invasive anti-cancer that employs photosensitizer with specific wavelength of light irradiation. PDT induces direct cell killing and enhancement effects on tumor immunity, but its underlying mechanism remains unknown. Here, we perform basic analysis the anti-tumor effect talaporfin sodium (TS)-PDT as well synergism immune checkpoint inhibitor anti-programmed death 1 (anti-PD-1) antibody. We estimate induced by TS-PDT induction damage-associated...
Introduction: Adequate bowel preparation is indispensable for high-quality colonoscopy. We have developed an ultralow-volume (500 ml) polyethylene glycol (PEG) combined with other laxatives (sennoside, sodium picosulfate, and lactulose) applied this regimen clinically to all patients colonoscopy three decades. This study aimed assess the effectiveness of regimen. Methods: single-center, retrospective analyzed data from consecutive outpatients who underwent between January 2022 December 2022....
Introduction: Cold snare polypectomy (CSP) and underwater endoscopic mucosal resection (UEMR) are used for small superficial nonampullary duodenal epithelial tumors (SNADETs). This study aimed to compare the depth of SNADETs removed by CSP versus UEMR. Methods: Data from resected with or UEMR between April 2018 July 2023 at Nagoya City University Hospital were collected retrospectively. An independent pathologist, blinded clinical information, evaluated specimens categorized into four...
Data on the safety profiles and clinical outcomes of patients with solid tumors cardiac metastasis treated immune checkpoint inhibitors (ICIs) are limited. This is an international multicenter retrospective study cancer at baseline. Patients who had received ≥1 dose ICI were included. Treatment-related adverse events (trAEs) graded per Common Terminology Criteria for Adverse Event V.5.0. Objective response rates (ORR) evaluated by Response Evaluation in Solid Tumors V.1.1 when available....
症例は70歳代女性.X-1年に悪性リンパ腫と診断され,R-CHOP療法が開始された.化学療法開始時のHBVマーカーは高感度HBs抗原陰性,HBc抗体陰性,HBs抗体基準値内(9.5 mIU/mL,基準値:10 mIU/mL未満)であり,HBV再活性化モニタリングは未施行であった.治療開始から13カ月後に肝機能障害を認め,HBs抗原の陽転化が判明しIgM-HBc抗体は陰性であった.R-CHOP療法前のHBs抗体価が基準値内高値であったことから既往感染からのde novo B型肝炎と診断した.HBs抗体単独陽性の既往感染者において,その判断に用いるHBs抗体価に明確な基準はない.HBs抗体のcut off値10 mIU/mLは最小感染防御抗体価であり既往感染を判断する基準値ではないことに留意し,高リスクな治療を行う際には定量結果にも着目する必要があると考えられた.
BRAF mutation has been recognized as a negative prognostic marker for metastatic colorectal cancer (mCRC), but these data are from common V600E-mutated mCRC. Combination therapy of inhibitor and anti-epidermal growth factor receptor (EGFR) antibody approved However, non-V600 mutations rare mutations, their clinical behavior is not understood. Moreover, the K601E extremely in mCRC, there have no reports on its specific treatment.
The carbohydrate structure of sialyl-Lewis X (SLex) can function as a ligand for E- and P-selectin, which play important roles in mediating the initial interactions leukocytes with endothelium inflammatory responses. In this study we evaluated effects inhibiting P-selectin SLex molecule on response an experimental murine model hypersensitivity pneumonitis (HP). Antigen exposure induced marked interstitial especially perivascular peribronchiolar infiltration lymphocytes granuloma formation,...
Sodium polystyrene sulfonate (SPS: Kayexalate®) is an ion-exchange resin used to treat hyperkalemia in patients with chronic kidney disease. It known that this sometimes causes colonic necrosis and perforation, but there are few reports about small bowel associated SPS. We herein report the case of a patient who developed SPS-induced necrosis, which was diagnosed based on examination endoscopic biopsy specimen. The resistant conservative treatment including cessation SPS, finally required...
Gastrointestinal stromal tumors occur frequently. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is performed commonly for diagnosis. However, the success rate of histological diagnosis insufficient when submucosal tumor (SMT) small. Recently, another technique, mucosal cutting biopsy (MCB) has been reported. The aim this study to evaluate efficacy and safety MCB.Between January 2012 August 2018, MCB EUS-FNA were 16 31 times diagnosing gastric SMT. diagnostic rate, successful...
<b><i>Introduction:</i></b> Endoscopic diagnosis is essential for predicting the curability of early gastric cancer (EGC; R0 resection) before treatment, but relationship between ulcerative lesions and clinical outcomes remains unclear. We aimed to investigate effect proton pump inhibitor (PPI) or potassium-competitive acid blocker (P-CAB) on morphological changes EGCs its relevance outcomes. <b><i>Methods:</i></b> Altogether, 143 patients with...
Colonic diverticular bleeding (CDB) is the most frequent cause of acute lower gastrointestinal bleeding. The aim this study was to evaluate efficacy and safety transcatheter arterial embolization (TAE) for CDB as first-line treatment with extravasation on contrast-enhanced computed tomography (CECT), compared endoscopic hemostasis. Three Japanese institutions participated in retrospective cohort study. Data from consecutive patients admitted a diagnosis CECT were reviewed. One hospital...
Abstract Photodynamic therapy (PDT) is a relatively non-invasive anti-cancer that employs photosensitizer with specific wavelength of light, causing photochemical reaction releases free radicals, thereby inducing tumor cell necrosis via oxidative stress. The oxygen molecule reaches the singlet excited state through efficient energy transfer from an triplet photosensitizer. Heavy atoms are frequently introduced in photosensitizers for efficiently generating reactive species (ROS) PDT, known...
Acute lower gastrointestinal bleeding (ALGIB) increase with age and the administration of antiplatelet drugs. Colonic diverticular (CDB) is most common cause ALGIB, endoscopic hemostasis an effective treatment for massive CDB. But in patients without extravasation on contrast-enhanced computed tomography (CECT), efficacy urgent colonoscopy (UCS) controversial from point clinical course, including rebleeding rate. We aimed to establish a potential strategy UCS CDB CECT. Patients two centers...
農夫肺は, 酪農従事者 (サイロでの干し草, 堆肥作成作業など) に認められる, 過敏性肺 (臓) 炎の一種である。欧米では, 最も古くから知られている過敏性肺 炎である。本邦では北海道, 岩手県, 北陸に多発する。発症の季節は, 主に11月から3月の冬季間に集中する。病因抗原は好熱性放線菌 (Thermoactinomyces) で, 主としてMicropolyspora faeniやThermoactinomyces vulgarisである。以前に比べて, 最近では, 予防のための数々の工夫, 例えば枯草を出来るだけ乾燥させビニール容器で包み密閉するなどの方法により, 枯れ草の発酵による発熱を防ぎ, 好熱性放線菌の繁殖を防ぐなどの環境改善がなされ, 罹患率が著しく低下した。しかしながら, 現在低容量慢性曝露による肺線維症が農村人口の高齢化と相俟って酪農地域の健康問題になりつつある。この線維化の進行を予防するには, 早期診断と継続的な職場の管理, および定期的な検査などによる健康管理が必要とされる。さらにまた, 近年新たな形の酪農に関係する職業環境汚染が生じつつあり, 看過出来ない。