A5103218850- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Pain Mechanisms and Treatments
- Cardiac Imaging and Diagnostics
- Atomic and Subatomic Physics Research
- Bladder and Urothelial Cancer Treatments
- Neuropeptides and Animal Physiology
- Lanthanide and Transition Metal Complexes
- Cancer, Hypoxia, and Metabolism
- Nuclear Physics and Applications
- Characterization and Applications of Magnetic Nanoparticles
- Phytoestrogen effects and research
- Medical Imaging Techniques and Applications
- Renal and related cancers
- Neuroinflammation and Neurodegeneration Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Immune cells in cancer
- Magnetic properties of thin films
- PARP inhibition in cancer therapy
- Occupational and environmental lung diseases
- Tuberous Sclerosis Complex Research
- Advanced Biosensing Techniques and Applications
- Body Composition Measurement Techniques
- Musicians’ Health and Performance
Kyushu University
2014-2022
Pharmac
2022
Iwate Medical University
2018-2021
Nagasaki University
2020-2021
Nagasaki Medical Center
2021
Johns Hopkins University
2017
General Electric (Japan)
2011-2012
Ritsumeikan University
2006
Yokogawa Electric (Japan)
2002-2003
University of Fukui
1993-1998
Spinal sensory transmission is under descending biphasic modulation, and facilitation believed to contribute chronic pain. Descending modulation from the brainstem rostral ventromedial medulla (RVM) has been most studied, whereas little known about direct corticospinal modulation. Here, we found that stimulation in anterior cingulate cortex (ACC) potentiated spinal excitatory synaptic this independent of RVM. Peripheral nerve injury enhanced occluded ACC-spinal cord facilitation. Inhibition...
The establishment of mechanism-driven peripheral markers is important for translational psychiatry. Many groups, including ours, have addressed molecular alterations in tissues association with symptomatic changes major illnesses. Oxidative stress implicated the pathophysiology schizophrenia (SZ) and bipolar disorder (BP) through studies patient animal models. Although relationship between brain pathology remain elusive, oxidative may bridge such efforts. Nonetheless, substrates are not well...
Sustained elevations in extracellular glutamate levels within astrocytes may precipitate epileptic seizures. In this report, chemical exchange saturation transfer imaging was used to measure brain concentrations a patient who underwent focal resection surgery. A male Japanese his 30s with drug-resistant epilepsy preoperative assessment at our institute. Preoperative magnetic resonance performed using an ultra-high-field system. The results of intracranial electroencephalography and were...
Abstract The apparent diffusion coefficients (ADCs) of water and brain metabolites were determined by proton MR spectroscopy on a clinical scanner for healthy volunteers pathological changes in cases acute cerebral infarction tumor. ADCs N ‐acetyl aspartate (NAA) creatines tissue involved decreased compared to normal control values, while tumors they showed increased values. Since NAA is neuronal marker, these findings suggest that cell viscosity according the status tissue. lactate ADC was...
PURPOSE: To evaluate the hemodynamics of acute stroke in cats by means dynamic susceptibility-contrast magnetic resonance (MR) imaging compared with standard T2- and diffusion-weighted MR imaging. MATERIALS AND METHODS: Unilateral permanent occlusion middle cerebral artery was performed 18 cats. each method 2 hours (n = 2), 6 10), 24 11) after occlusion. RESULTS: At every time point, images clearly showed ischemic regions steady-state signal hyperintensity areas less decrease intensity that...
The role of astrocytes in the spinal dorsal horn (SDH) for sensory information processing under normal conditions is poorly understood. In this study, we investigated whether SDH respond to noxious and innocuous stimuli skin mice using vivo two-photon Ca2+ imaging anesthesia. We found that stimulation evoked by intraplantar formalin injection provoked an elevation intracellular levels astrocytes. By contrast, neither instantaneous pinching nor (cooling or brushing) hindpaw elicited...
Background/Aim: A previous report showed that immune complex-ceruloplasmin (CP) in urine is associated with carcinogenesis and malignant behavior bladder cancer (BC). We investigated the pathological significance prognostic roles of tissue levels CP protein BC patients. Materials Methods: Urine were measured using an enzyme-linked immunosorbent assay 97 expression tissues was evaluated by immunohistochemical analysis 176 patient samples. Results: positively tumor grade pT stage non-muscle...
The purpose of this study was to evaluate cerebral perfusion with T2*-weighted dynamic MRI in the area around infarcted core. We examined seven patients subacute infarction. After bolus injection a gadopentetate dimeglumine, series gradient-echo images were recorded selected slice. From these images, concentration-time curves created on region-of-interest (ROI) basis infarction for calculating relative regional blood volume (rrCBV). Brain single photon emission computed tomography (SPECT)...
To assess the clinical utility of a new method for real-time estimation T1 during first pass contrast agent by using this to examine brain tumors.The multi-phase spoiled gradient-echo pulse sequence double-echo magnetic resonance (MR) technique was modified. In half sequence, flip angle varied systematically. Then, static values were calculated differences in MR signal intensities between different angles. latter changes absolute before and after injection agent. The data used minimize T2*...
Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is a rare neurodegenerative disorder various clinical presentations. Mutation of the colony-stimulating factor 1 receptor (CSF1R) gene considered to be cause this autosomal dominant disorder. The purpose study was report magnetic resonance spectroscopy (MRS) findings in patients HDLS and asymptomatic carriers clarify use MRS disease.In retrospective, institutional review board-approved study, we included four consecutive patients,...
Using a questionnaire, we surveyed 2,500 facilities in Japan to clarify medical accidents concerning the magnetic resonance device and its environment. Data derived from 1,319 valid responses (52.8%), allowed us analyze situation of (or reason for) occurrence their environmental factors. Five hundred nine (39% all facilities) had experience magnetically induced displacement large ferromagnetic material. Intravenous (I.V.) drip stands were involved largest number them: 31% (228 cases). Oxygen...
The pathological significance of thrombospondin (TSP)-1 and -2 in bladder cancer (BC) is well-known whereas that TSP-3, 4 5 remains unclear. Our aim to clarify the prognostic roles TSP-3 expression BC patients.TSP-3 expression, proliferation index (PI), apoptotic (AI) microvessel density (MVD) were evaluated 206 patients by immunohistochemical techniques.TSP-5 was positively associated with grade, T stage, metastasis, worse prognosis. PI TSP-5-positive tissues significantly higher compared...