A5067053098- MicroRNA in disease regulation
- Health disparities and outcomes
- Circular RNAs in diseases
- Extracellular vesicles in disease
- IoT and Edge/Fog Computing
- Immune cells in cancer
- Ultrasound and Hyperthermia Applications
- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- Aging and Gerontology Research
- Cancer-related molecular mechanisms research
- Technology Adoption and User Behaviour
- Nanoplatforms for cancer theranostics
- Telemedicine and Telehealth Implementation
- Cancer Immunotherapy and Biomarkers
- Chronic Disease Management Strategies
- Wireless Body Area Networks
- Congenital heart defects research
- Phagocytosis and Immune Regulation
First Affiliated Hospital of Zhengzhou University
2022-2025
Henan Provincial Institute of Occupational Health
2023-2024
Henan Cancer Hospital
2012-2023
Zhengzhou University
2014-2023
Intelligent Health (United Kingdom)
2023
Exosome is crucial mediator and play an important role in tumor angiogenesis. Tip cell formation a prerequisite for persistent angiogenesis which causes metastasis. However, the functions underlying mechanisms of cell-derived exosomes tip remain less understood.
Abstract Objective: Population-based cancer registration data in 2012 from all available registries Henan province were collected by Office for Cancer Research and Control. The numbers of new cases deaths with compiled incidence mortality rates estimated. Methods: In 2015, registries' qualified the national registry annual report 2012. pooled stratified area (urban/rural), gender, age group (0, 1.4, 5.9, 10.14, …, 85+) type. New estimated using age-specific corresponding population Chinese...
Abstract Background This study aimed to examine the bidirectional relationship between social isolation and cognitive performance among Chinese middle-aged older adults. Methods We used four waves of data from China Health Retirement Longitudinal Study. A latent growth model (LGM) was applied association across different characteristics. Results In analysis, we ultimately included 9,367 participants after excluding respondents with missing key variables. Social showed significant differences...
Atherosclerosis (AS) is a chronic inflammatory disease of large and medium-sized arteries that leads to ischemic heart disease, stroke, peripheral vascular disease. Despite the current treatments, mortality disability still remain high. Sonodynamic therapy (SDT), non-invasive localized methodology, has been developed as promising new treatment for inhibiting atherosclerotic progression stabilizing plaques. Promising progress made through cell animal assays, well clinical trials. For example,...
The interplay between long non-coding RNAs (lncRNAs) and the Notch pathway involves a variety of malignancies. However, Notch-derived lncRNAs their latent clinical significance remain elusive in colorectal cancer (CRC). In this study, we introduced framework that could screen (named "NLncer") ultimately identified 24 NLncers. To further explore these NLncers, performed LASSO Cox regression TCGA-CRC cohort (n = 584) then retained six tightly associated with prognosis. final model (termed...
Immune escape is identified as one of the reasons for poor prognosis colorectal cancer (CRC) patients. Circular RNAs are considered to promote tumor progression by mediating immune escape. We discovered that higher expression circYAP1 was associated with a worse CRC Functional experiments
To explore the application of instantaneous wave intensity for early diagnosis systemic lupus erythematosus (SLE)-induced atherosclerosis, we observed carotid elasticity by in premenopausal women with SLE.The study included 3 groups (each group 30 participants): SLE1 (course disease <5 years), SLE2 ≥5 years) and healthy control. Carotid parameters, including acceleration intensity, deceleration negative area, stiffness constant, pulse velocity, constant pressure strain elastic modulus,...
We aim to establish an LPS-induced human aortic endothelial cells (HAECs) inflammatory injury model and explore the optimal conditions for inducing its injury. expect provide modeling references related experiments of vascular diseases. HAECs were cultured in vitro treated with different concentrations lipopolysaccharide (LPS) (0.1, 1, 10, 50, 100 μg/mL) 6, 12, 24 h model. The cell viability was determined by CCK-8 assay; expression levels cytokines detected RT-PCR;the apoptosis rate flow...
Background To date, the differentiated requirements for network performance in various health care service scenarios—within, outside, and between hospitals—remain a key challenge that restricts development implementation of digital medical services. Objective This study aims to construct implement private 5G (the 5th generation mobile communication technology) standalone (SA) smart environment meet diverse needs Methods Based on an analysis differentiation applications, system architecture...
Background The prevalence of combinations comorbidities and their associations with inpatient service utilization readmission among patients chronic obstructive pulmonary disease (COPD) have not been extensively examined. To address this gap in knowledge, an observational prospective study was conducted using retrospective data.
The extent to which type 2 diabetes (T2D) reduces life expectancy depends on the risk of complications. We aimed characterise relationship between factors for complications and expectancy, in individuals with T2D, free from major chronic disease, a regional database linked national New Zealand health databases.
Introduction To evaluate the long-term risk of developing type 2 diabetes (T2D) among women with a history gestational mellitus (GDM) compared those impaired glucose tolerance (IGT). Research design and methods Using data from primary care dataset linked multiple health registries, this longitudinal study analyzed demographics, clinical data, lifestyle factors diagnosed GDM or IGT, assessing T2D incidence over 25 years, using Cox regression models. Results Women GDM, especially 35 years...
Abstract Pulmonary atresia (PA) is a severe cyanotic congenital heart disease. Although some genetic mutations have been described to be associated with PA, the knowledge of pathogenesis insufficient. The aim this research was use whole-exome sequencing (WES) determine novel rare variants in PA patients. We performed WES 33 patients (27 patient–parent trios and 6 single probands) 300 healthy control individuals. By applying an enhanced analytical framework incorporate de novo case–control...