A5076956380- Malaria Research and Control
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Computational Drug Discovery Methods
- Adolescent Sexual and Reproductive Health
- HIV/AIDS Research and Interventions
- Global Health and Epidemiology
- Global Public Health Policies and Epidemiology
- Reproductive tract infections research
- Syphilis Diagnosis and Treatment
- Child Nutrition and Water Access
- Vibrio bacteria research studies
- HIV-related health complications and treatments
- Medical Coding and Health Information
- School Health and Nursing Education
- Vector-borne infectious diseases
- Poverty, Education, and Child Welfare
- Healthcare Systems and Reforms
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Breastfeeding Practices and Influences
- Health Literacy and Information Accessibility
- Data-Driven Disease Surveillance
- Hepatitis Viruses Studies and Epidemiology
- Female Genital Mutilation/Cutting Issues
National Institute for Medical Research
2013-2024
ORCID
2020
Eckernforde Tanga University
2017
The Francis Crick Institute
2012
High-throughput Plasmodium genomic data is increasingly useful in assessing prevalence of clinically important mutations and malaria transmission patterns. Understanding parasite diversity for identification specific human or populations that can be targeted by control programmes, to monitor the spread associated with drug resistance. An up-to-date understanding regional population dynamics also critical impact efforts. However, this largely absent from high-burden nations Africa, date, no...
Abstract Background Despite significant decline in the past two decades, malaria is still a major public health concern Tanzania; with over 93% of population at risk. Community knowledge, attitudes and practices (KAP), beliefs are key enhancing uptake utilization control interventions, but there lack information on their contribution to effective disease. This study was undertaken determine KAP community members service providers malaria, how they might be associated increased risk...
Therapeutic efficacy studies (TESs) and detection of molecular markers drug resistance are recommended by the World Health Organization (WHO) to monitor artemisinin-based combination therapy (ACT). This study assessed trends artemisinin and/or reduced susceptibility lumefantrine using samples collected in TES conducted Mainland Tanzania from 2016 2021.
Globally, large numbers of children die shortly after birth and many them within the first 4 wk life. This study aimed to determine trends, patterns causes neonatal mortality in hospitals Tanzania during 2006-2015.This retrospective involved 35 hospitals. Mortality data were extracted from inpatient registers, death registers International Classification Diseases-10 report forms. Annual specific hospital-based rates calculated discussed. Two periods 2006-2010 2011-2015 assessed separately...
Understanding the causes of inpatient mortality in hospitals is important for monitoring population health and evidence-based planning curative public care. Dearth information on trends hospital most countries Sub-Saharan Africa has resulted to wide use model-based estimation methods which are characterized by errors. This retrospective analysis used primary data determine cause-specific patterns among deaths Tanzania from 2006-2015.
By the end of 2009 an estimated 2.5 million children worldwide were living with HIV-1, mostly as a consequence vertical transmission, and more than 90% these live in sub-Saharan Africa. In 2008 World Health Organization (WHO), recommended early initiation Highly Active Antiretroviral Therapy (HAART) to all HIV infected infants diagnosed within first year life, since 2010, two years irrespective CD4 count or WHO clinical stage. The study aims describe implementation EID programs three...
This retrospective study sought to determine the type, burden, and pattern of cancer deaths in public hospitals Tanzania from 2006 2015.This analyzed data on mortality 39 Tanzania. Data age sex deceased type were extracted hospital death registers report forms. Cancer types grouped according 10th revision International Classification Diseases. Age-standardized rates patterns analyzed. A χ2 test was used examine association between common cancers selected covariates.A total 12,621...
Although the recent decline of malaria burden in some African countries has been attributed to a scale-up interventions, such as bed nets (insecticide-treated nets, ITNs/long-lasting insecticidal LLINs), contribution other factors these changes not rigorously assessed. This study assessed trends Plasmodium falciparum prevalence Magoda (1992–2017) and Mpapayu (1998–2017) villages Muheza district, North-eastern Tanzania, relation levels different interventions rainfall patterns. Individuals...
Highly Active Antiretroviral Therapy (HAART) has been available free of charge in Tanga, Tanzania since 2005. However we have found that a high percentage women referred from prevention mother-to-child transmission services to the Care and Treatment Clinics (CTC) for HAART never registered at CTCs. Few studies focused on motivating deterring factors presenting particularly relation women. This study seeks remedy this gap knowledge.A qualitative approach using in-depth interviews focus group...
Abstract Background Histidine-rich protein 2 (HRP2)-based malaria rapid diagnostic tests (RDTs) are effective and widely used for the detection of wild-type Plasmodium falciparum infections. Although recent studies have reported false negative HRP2 RDT results due to pfhrp2 pfhrp3 gene deletions in different countries, there is a paucity data on these genes Tanzania. Methods A community-based cross-sectional survey was conducted between July November 2017 four regions: Geita, Kigoma, Mtwara...
Abstract Background Artemisinin-based combination therapies (ACTs) have been a major contributor to the substantial reductions in global malaria morbidity and mortality over last decade. In Tanzania, artemether-lumefantrine (AL) was introduced as first-line treatment for uncomplicated Plasmodium falciparum 2006. The WHO recommends regular assessment monitoring of efficacy treatment, specifically considering that artemisinin resistance has confirmed Greater Mekong sub-region. This study's...
Accurate and reliable hospital information on the pattern causes of death is important to monitor evaluate effectiveness health policies programs. The objective this study was assess availability, accessibility, quality mortality data in Tanzania. This cross-sectional involved selected hospitals Tanzania carried out from July October 2016. Review registers forms cover a period 10 years (2006–2015). Interviews with staff were conducted seek as regards tools used record data, recording...
The Tanzanian National Malaria Control Programme (NMCP) and its partners have been implementing regular therapeutic efficacy studies (TES) to monitor the performance of different drugs used or with potential use in Tanzania. However, most recent TES focused on artemether-lumefantrine, which is first-line anti-malarial for treatment uncomplicated falciparum malaria. Data other artemisinin-based combinations urgently needed support timely review changes guidelines case drug resistance current...
Abstract Background It has been more than 20 years since the malaria epidemiologic shift to school-aged children was noted. In meantime, (5–15 years) have become increasingly vulnerable with asymptomatic prevalence reaching up 70%, making them reservoirs for subsequent transmission of in endemic communities. Intermittent Preventive Treatment schoolchildren (IPTsc) proven be an effective tool shrink this reservoir. As 3 rd June 2022, World Health Organization recommends IPTsc moderate and...
We determined the prevalence and reported risk factors associated with sexually transmitted reproductive tract infections (STI/RTIs) among patients who presented genital symptoms in STI/outpatient department (OPD) clinics two regional referral hospitals six health centres regions Tanzania. Methods: The were consecutively recruited, data collection was conducted eight care facilities from 2014 to 2016. Genital swabs collected for detection of aetiological pathogens STI/RTIs. Results: A total...
Abstract Objective To determine the causes, patterns and trends of respiratory diseases‐related deaths in hospitals Tanzania 2006–2015. Methods Retrospective study involving 39 hospitals. Medical records patients who died hospital were retrieved, reviewed analysed. Sources data admission registers, death registers International Classification Diseases report forms. Information on demographic characteristics, date death, immediate underlying cause co‐morbid conditions was collected. Results...
Malaria remains the most important cause of morbidity and mortality in Tanzania. However, its prevalence varies from area to depending on various ecological, socio-economic health system factors. This study was carried out determine malaria associated factors among rice farming communities Kilangali village Kilosa District Central Tanzania.A cross-sectional conducted May 2015, involving randomly selected persons living six sub-villages village, namely Mlegeni, Kisiwani, Makuruwili,...
This study aimed to determine the prevalence of sexually transmitted infections (STIs) among HIV-infected and uninfected pregnant women in Tanga, Tanzania. Retrospective data on syphilis HIV status during 2008–2010 were collected from antenatal clinic (ANC) records. Prospective ( n = 105) HIV-uninfected 100) attending ANCs between April 2009 August 2010. Syphilis showed a declining trend (3.1%, 1.4% 1.3%), while was stable (6.1%, 6.4% 5.4%) 2008–2010. had significantly higher trichomoniasis...
Abstract Background Diversification of artemisinin-based combination therapy (ACT) is suggested as one the strategies that can be used to contain artemisinin resistance. Artesunate-amodiaquine (ASAQ) combinations in diversification strategy an alternative first-line treatment for uncomplicated malaria mainland Tanzania. There however limited data on efficacy ASAQ This study assessed Plasmodium falciparum selected sentinel sites therapeutic studies Methods Between December 2018 and March...
Abstract Background The use of artemisinin-based combination therapy (ACT) is recommended by the World Health Organization for treatment uncomplicated falciparum malaria. Artemether-lumefantrine (AL) most widely adopted first-line ACT malaria in sub-Saharan Africa (SSA), including mainland Tanzania, where it was introduced December 2006. WHO recommends regular assessment to monitor efficacy specifically considering that artemisinin partial resistance reported Greater Mekong sub-region and...
Abstract Background Artemisinin-based combination therapy (ACT) has been a major contributor to the substantial reductions in global malaria morbidity and mortality over last decade. In Tanzania, artemether-lumefantrine (AL) was introduced as first-line treatment for uncomplicated Plasmodium falciparum 2006. The World Health Organization (WHO) recommends regular assessment monitoring of efficacy treatment, specifically considering that artemisinin resistance confirmed Greater Mekong...
Although death records are useful for planning and monitoring health interventions, such information is limited in most developing countries. Verbal autopsy (VA) interviews alternatively used to determine causes of places without or with incomplete hospital records. This study was conducted all cause-specific mortality Korogwe demographic surveillance system (HDSS) undertaken district, northeastern Tanzania.The from January 2006 December 2012 14 villages under HDSS. Vital events as births,...
This study was performed to determine the seroprevalence and incidence of hepatitis E virus (HEV) infection among HIV-infected women during pregnancy after delivery in a cohort 200 Tanzanian women.HIV-infected participating on antiretroviral therapy for prevention mother-to-child HIV transmission between 2006 2011, were tested retrospectively anti-HEV immunoglobulin G (IgG) plasma samples at 9 months post-partum. Anti-HEV IgG-positive patients IgG M (IgM) from enrolment, seroconverting HEV...
Introduction Risk factors for breast milk transmission of HIV-1 from mother to child include high plasma and viral load, low maternal CD4 count pathology such as mastitis. Objective To determine the impact nevirapine subclinical mastitis on RNA in after intrapartum single-dose combined with either 1-week tail Combivir (zidovudine/lamivudine) or Truvada (tenofovir/emtricitabine). Methods Maternal bilateral samples were collected between April 2008 2011 at 1, 4 6 weeks postpartum HIV-infected...
Malaria rapid diagnostic tests (RDTs) based on the detection of Plasmodium falciparum histidine-rich protein 2 (HRP2) antigen are widely used for active infection with this parasite and only practical malaria test in some endemic settings. External validation RDT results from field surveys can confirm appropriate performance.A community-based cross-sectional survey was conducted between July November 2017 enrolling participants all ages households 15 villages four border regions Tanzania:...