A5012218262- Single-cell and spatial transcriptomics
- Mathematical Biology Tumor Growth
- Gene Regulatory Network Analysis
- 3D Printing in Biomedical Research
- Diet and metabolism studies
- Cell Image Analysis Techniques
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
Indiana University Bloomington
2022-2025
Abstract Functional tissue units form the basic building blocks of organs and are important for understanding modeling healthy physiological function organ changes that occur during disease states. In this comprehensive catalog 22 anatomically based, nested functional from 10 human organs, we document definition, physical dimensions, blood vasculature connections, cellular composition. All anatomy terms mapped to multi-species Uber-anatomy Ontology (Uberon) cells Cell support computational...
Abstract The Human BioMolecular Atlas Program (HuBMAP) aims to construct a 3D Reference (HRA) of the healthy adult body. Experts from 20+ consortia collaborate develop Common Coordinate Framework (CCF), knowledge graphs and tools that describe multiscale structure human body (from organs tissues down cells, genes biomarkers) use HRA characterize changes occur with aging, disease other perturbations. v.2.0 covers 4,499 unique anatomical structures, 1,195 cell types 2,089 biomarkers (such as...
Pharmacokinetics and pharmacodynamics (PKPD) are key considerations in any study of molecular therapies. It is thus imperative to factor their effects into silico model biological tissue involving such Furthermore, creating a standardized flexible framework will benefit the community by increasing access modules enhancing communicability. PhysiCell an open-source physics-based cell simulator, i.e., platform for modeling tissue, that quickly being adopted utilized mathematical biology...
Abstract Functional tissue units (FTUs) form the basic building blocks of organs and are important for understanding modeling healthy physiological function organ changes during disease states. In this first comprehensive catalog FTUs, we document definition, physical dimensions, vasculature, cellular composition 22 anatomically correct, nested functional in 10 human organs. The includes datasets, illustrations, an interactive online FTU explorer, a large printable poster. All data code...
Abstract Pharmacokinetics and pharmacodynamics are key considerations in any study of molecular therapies. It is thus imperative to factor their effects silico model biological tissue involving such Furthermore, creation a standardized flexible framework will benefit the community by increasing access modules enhancing communicability. PhysiCell an open source physics-based cell simulator, i.e. platform for modeling tissue, that quickly being adopted utilized mathematical biology community....