A5020962914- Hemodynamic Monitoring and Therapy
- Engineering Technology and Methodologies
- RNA and protein synthesis mechanisms
- Bacteriophages and microbial interactions
- Medical Image Segmentation Techniques
- RNA Research and Splicing
- Single-cell and spatial transcriptomics
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Hedgehog Signaling Pathway Studies
- Machine Learning in Healthcare
- Cell Image Analysis Techniques
- Artificial Intelligence in Healthcare
- Cancer Cells and Metastasis
- COVID-19 diagnosis using AI
- Cancer Genomics and Diagnostics
- Lymphatic System and Diseases
- Biomedical Text Mining and Ontologies
Indiana University Bloomington
2025
RedCLARA
2022
University of Illinois Chicago
2022
Princeton University
2020-2021
Abstract A mechanistic understanding of the SARS-CoV-2 viral replication cycle is essential to develop new therapies for COVID-19 global health crisis. In this study, we show that nucleocapsid protein (N-protein) undergoes liquid-liquid phase separation (LLPS) with genome, and propose a model packaging through LLPS. N-protein condenses specific RNA sequences in first 1000 nts (5’-End) under physiological conditions enhanced at human upper airway temperatures. condensates exclude non-packaged...
Abstract The Human BioMolecular Atlas Program (HuBMAP) aims to construct a 3D Reference (HRA) of the healthy adult body. Experts from 20+ consortia collaborate develop Common Coordinate Framework (CCF), knowledge graphs and tools that describe multiscale structure human body (from organs tissues down cells, genes biomarkers) use HRA characterize changes occur with aging, disease other perturbations. v.2.0 covers 4,499 unique anatomical structures, 1,195 cell types 2,089 biomarkers (such as...
Abstract More than 150 scientists from 17 consortia are collaborating on an international project to build a Human Reference Atlas, which maps all 37 trillion cells in the healthy adult human body. The initial release of this atlas provided hierarchical lists anatomical structures, cell types, and biomarkers 11 organs. Here, we describe methods used as part initiative first open, computer-readable, comprehensive database blood vasculature, called Atlas-Vasculature Common Coordinate Framework...
Abstract Background Various machine learning and artificial intelligence methods have been used to predict outcomes of hospitalized COVID-19 patients. However, process mining has not yet for prediction. We developed a mining/deep approach mortality among patients updated the prediction in 6-h intervals during first 72 h after hospital admission. Methods The model produced temporal information related variables incorporated demographic clinical data mortality. was Moreover, performance...
1. Abstract This paper reviews efforts across 16 international consortia to construct human anatomical structures, cell types, and biomarkers (ASCT+B) tables three-dimensional reference organs in support of a Human Reference Atlas. We detail the ontological descriptions spatial representations together with user interfaces that registration exploration tissue data. Four use cases are presented demonstrate utility ASCT+B for advancing biomedical research improving health.
Abstract Background While substantial anatomical study has been pursued throughout the human body, of lymphatic system remains in its infancy. For microsurgeons specializing surgery, a better command anatomy is needed to further our ability offer surgical interventions with precision. In an effort facilitate dissemination and advancement knowledge, teams worked together create map. The aim this paper present experience mapping system. Methods Three steps were followed develop modern map...
We report that the SARS-CoV-2 nucleocapsid protein (N-protein) undergoes liquid-liquid phase separation (LLPS) with viral genome and propose a model of packaging through LLPS. N-protein condenses specific RNA sequences in first 1000 nts (5'-End) under physiological conditions condensation is enhanced at human body temperatures. Other regions gRNA promote dissolution, counteracting aggregation large genome. This combination elements ensures condensates both molecular physical identity,...
Abstract More than 150 scientists from 17 consortia are collaborating on an international project to build a Human Reference Atlas, which maps all 37 trillion cells in the healthy adult human body. The initial release of this atlas provided hierarchical lists anatomical structures, cell types, and biomarkers 11 organs. Here, we describe methods used as part initiative first open, computer-readable, comprehensive database blood vasculature, called Atlas-Vasculature Common Coordinate Framework...