A5025797593- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Axon Guidance and Neuronal Signaling
- Zebrafish Biomedical Research Applications
- Neurobiology and Insect Physiology Research
- Hippo pathway signaling and YAP/TAZ
- Cell Image Analysis Techniques
- Biomedical Text Mining and Ontologies
- Neurogenesis and neuroplasticity mechanisms
- Heat shock proteins research
- Cellular transport and secretion
- Genetics, Aging, and Longevity in Model Organisms
- Computer Graphics and Visualization Techniques
- Hate Speech and Cyberbullying Detection
- RNA and protein synthesis mechanisms
- Scientific Computing and Data Management
- Invertebrate Immune Response Mechanisms
- 3D Shape Modeling and Analysis
- Cancer Cells and Metastasis
- Developmental Biology and Gene Regulation
- interferon and immune responses
- Genomics and Chromatin Dynamics
- Anatomy and Medical Technology
- Ubiquitin and proteasome pathways
National Institute of Allergy and Infectious Diseases
2021-2025
National Institutes of Health
2021-2025
Intelligent Systems Research (United States)
2022
Indiana University Bloomington
2022
University of British Columbia
2009-2016
University of Victoria
2008
Trinity College Dublin
1938
Abstract The Human BioMolecular Atlas Program (HuBMAP) aims to construct a 3D Reference (HRA) of the healthy adult body. Experts from 20+ consortia collaborate develop Common Coordinate Framework (CCF), knowledge graphs and tools that describe multiscale structure human body (from organs tissues down cells, genes biomarkers) use HRA characterize changes occur with aging, disease other perturbations. v.2.0 covers 4,499 unique anatomical structures, 1,195 cell types 2,089 biomarkers (such as...
A relatively unique feature of papillomaviruses is that the viral genome associated with host histones inside virion. However, little known about nature epigenome within papillomavirions or its biological relevance to infectious cycle.
Seventeen international consortia are collaborating on a human reference atlas (HRA), comprehensive, high-resolution, three-dimensional of all the cells in healthy body. Laboratories around world collecting tissue specimens from donors varying sex, age, ethnicity, and body mass index. However, harmonizing data across 25 organs more than 15 bulk spatial single-cell assay types poses challenges. Here, we present software tools user interfaces developed to spatially semantically annotate...
Developing neuronal growth cones respond to a number of post-transcriptionally modified guidance cues establish functional neural networks. The Semaphorin family has well-established roles as both secreted and transmembrane cues. Here, we describe the first evidence that Semaphorin, 5B (Sema5B), is proteolytically processed from its form can function soluble cone collapsing cue. Over-expression A Disintegrin Metalloprotease (ADAM)-17, results in an enhanced release Sema5B ectodomain, while...
The tricellular junction (TCJ) forms at the convergence of bicellular junctions from three adjacent cells in polarized epithelia and is necessary for maintaining transepithelial barrier. In fruitfly Drosophila, TCJ generated meeting point septate junctions. Gliotactin was first identified component development. a member neuroligin family associates with PDZ protein discs large. Beyond this interaction, little known about mechanisms underlying localization function TCJ. study, we show that...
1. Abstract This paper reviews efforts across 16 international consortia to construct human anatomical structures, cell types, and biomarkers (ASCT+B) tables three-dimensional reference organs in support of a Human Reference Atlas. We detail the ontological descriptions spatial representations together with user interfaces that registration exploration tissue data. Four use cases are presented demonstrate utility ASCT+B for advancing biomedical research improving health.
Glial cells of both vertebrate and invertebrate organisms must migrate to final target regions in order ensheath support associated neurons. While recent progress has been made describe the live migration glial developing pupal wing (1), studies Drosophila cell have typically involved examination fixed tissue. Live microscopic analysis motile offers ability examine cellular behavior throughout migratory process, including determining rate changes direction growth. Paired with use genetic...
Abstract Several international consortia are collaborating to construct a human reference atlas, which is comprehensive, high-resolution, three-dimensional atlas of all the cells in healthy body. Laboratories around world collecting tissue specimens from donors varying sex, age, ethnicity, and body mass index. However, integrating harmonizing data across 20+ organs more than 15 bulk spatial single-cell assay types poses diverse challenges. Here we present software tools user interfaces...
The National Institutes of Health's (NIH) Human Biomolecular Atlas Program (HuBMAP) aims to create a comprehensive high-resolution atlas all the cells in healthy human body. Multiple laboratories across United States are collecting tissue specimens from different organs donors who vary sex, age, and body size. Integrating harmonizing data derived these samples 'mapping' them into common three-dimensional (3D) space is major challenge. key making this possible 'Common Coordinate Framework'...
The CCF Organ VR Gallery lets the user explore 21 human organs, journeying from Whole Body, to Organ, Cell stage and back, presented in real-world size 3D. discovers hidden regions by exploding collapsing organs into their individual anatomical structures. We show cell type populations for a kidney using data-driven dot density visualization. organ models were developed map trillions of cells Human BioMolecular Atlas Program (HuBMAP).
The Human BioMolecular Atlas Program (HuBMAP) aims to create a computable, open Reference (HRA) [1]. This HRA will redefine our understanding of the human body by recovering multi-scale tissue organization from single cell resolution. In initial three years project, we created an authoritative ontology anatomical structures, types, and biomarkers; this structure terminology was then linked three-dimensional reference objects in size shape organs, functional units, micro-structures [2]. Many...