A5100342823- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Echinoderm biology and ecology
- Food Quality and Safety Studies
- Neurological Disease Mechanisms and Treatments
- Seaweed-derived Bioactive Compounds
- Aquatic life and conservation
- Single-cell and spatial transcriptomics
- Polysaccharides and Plant Cell Walls
- Neurobiology and Insect Physiology Research
- Cytomegalovirus and herpesvirus research
- Immune cells in cancer
- Microbial Metabolites in Food Biotechnology
- Multiple Sclerosis Research Studies
- Medical Imaging and Analysis
- Salivary Gland Disorders and Functions
- Chemokine receptors and signaling
- Fermentation and Sensory Analysis
- Bioeconomy and Sustainability Development
- Seed and Plant Biochemistry
- MRI in cancer diagnosis
- Sensory Analysis and Statistical Methods
- Retinal Development and Disorders
- Antioxidants, Aging, Portulaca oleracea
- Vitamin C and Antioxidants Research
Columbia University Irving Medical Center
2023-2025
Columbia University
2024
Shanxi Datong University
2024
Binzhou Medical University
2013-2022
Queen Mary University of London
2020-2022
Wenzhou University
2016-2022
Binzhou University
2013-2022
Beijing Technology and Business University
2017
Tongji Hospital
2015
Huazhong University of Science and Technology
2015
Feeding mice with the SFPS, a kind of polysaccharide extracted from<italic>Sargassum fusiforme</italic>, delays aging process.
Sulfakinin (SK)/cholecystokinin (CCK)-type neuropeptides regulate feeding and digestion in protostomes (e.g. insects) chordates. Here, we characterised SK/CCK-type signalling for the first time a non-chordate deuterostome – starfish Asterias rubens (phylum Echinodermata). In this species, two (ArSK/CCK1, ArSK/CCK2) derived from precursor protein ArSK/CCKP act as ligands an receptor (ArSK/CCKR) these peptides/proteins are expressed nervous system, digestive tube feet, body wall. Furthermore,...
Somatostatin (SS) and allatostatin-C (ASTC) are inhibitory neuropeptides in chordates protostomes, respectively, which hitherto were identified as orthologs. However, echinoderms have two SS/ASTC-type (SS1 SS2), here, our analysis of sequence data indicates that SS1 is an ortholog ASTC SS2 SS. The occurrence both SS-type ASTC-type provides a unique context to compare their physiological roles. Investigation the expression actions neuropeptide ArSS1 starfish Asterias rubens revealed it causes...
Human microglial heterogeneity is only beginning to be appreciated at the molecular level. Here, we present a large, single-cell atlas of expression signatures from 441,088 live microglia broadly sampled across diverse set brain regions and neurodegenerative neuroinflammatory diseases obtained 161 donors autopsy or during neurosurgical procedure. Using hierarchical Poisson factorization (scHPF), derived 23-factor model for continuous gene which capture specific biological processes (e.g.,...
Somatostatin (SS) and allatostatin-C (ASTC) are structurally evolutionarily related neuropeptides that act as inhibitory regulators of physiological processes in mammals insects, respectively. Here, we report the first molecular functional characterization SS/ASTC-type signalling a deuterostome invertebrate—the starfish Asterias rubens (phylum Echinodermata). Two precursors were identified A. (ArSSP1 ArSSP2) structures derived from these proteins (ArSS1 ArSS2) analysed using mass...
Summary Background Microglia, the brain’s resident immune cells, play vital roles in brain development, and disorders like Alzheimer’s disease (AD). Human iPSC-derived microglia (iMG) provide a promising model to study these processes. However, existing iMG generation protocols face challenges, such as prolonged differentiation time, lack of detailed characterization, limited gene function investigation via CRISPR-Cas9. Methods Our integrated toolkit for in-vitro functional genomics...
Recent investigations of cell type changes in Multiple Sclerosis (MS) using single-cell profiling methods have focused on active lesional and peri-lesional brain tissue, implicated a number peripheral central nervous system types. However, an important question is the extent to which so-called "normal-appearing" non-lesional tissue individuals with MS accumulate over lifespan. Here, we compared post-mortem from donors pathological or clinical diagnosis Religious Orders Study Rush Memory...
In order to better explore the antibacterial chemical constituents and activity of Astragalus Hengshan honey. this study, honey was taken as research object, Shanxi Jingtiao honey, Acacia Xinjiang jujube Longxi were control. The bacteriostatic effect on Staphylococcus aureus, Escherichia coli Pseudomonas aeruginosa evaluated by drilling method through physicochemical experiment UHPLC-MS. results showed that pH value low flavonoid content high (0.349mg·g-1). There abundant secondary...
Immunosenescence (ISC), the aging of immune system, has largely been studied in populations European descent. Here, circulating cell cytometric data from African-American, Hispanic, and non-Hispanic White participants were generated. Known novel age effects identified using either a meta-analysis approach or parallel genetic approach. Most results are consistent across three populations, but some display evidence heterogeneity, such as PD-L1
Abstract Background Glial cells exhibit distinct transcriptional responses to β‐amyloid pathology in Alzheimer’s disease (AD). While sophisticated single‐cell based methods have revealed heterogeneous glial subpopulations the human AD brain, histological localization of these multicellular has not been fully characterized due loss spatial information. Here, we combined transcriptomics (ST) with immunohistochemistry explore molecular mechanisms neuritic plaque niche. Methods 32 sections from...
Plants have provided a source of inspiration new therapeutic agents for human as well agricultural production, considerable proportion the world's population depends on traditional medicine systems various or crop diseases.Their role is twofold; namely they provide key chemical structure development antimicrobial drugs and also phytomedicines to be used treatment diseases in crops 1,2 .Although advances been made pharmacology synthetic organic chemistry, this reliance natural products,...