A5010212280- Environmental Toxicology and Ecotoxicology
- Cancer, Lipids, and Metabolism
- Toxic Organic Pollutants Impact
- Reproductive biology and impacts on aquatic species
- Physiological and biochemical adaptations
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- MicroRNA in disease regulation
- Zebrafish Biomedical Research Applications
- Congenital heart defects research
- Cell death mechanisms and regulation
- Epigenetics and DNA Methylation
- Zeolite Catalysis and Synthesis
- Mercury impact and mitigation studies
- Peroxisome Proliferator-Activated Receptors
- Aquaculture disease management and microbiota
- Advanced biosensing and bioanalysis techniques
- Nitric Oxide and Endothelin Effects
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- TGF-β signaling in diseases
- FOXO transcription factor regulation
- Hedgehog Signaling Pathway Studies
Minzu University of China
2022-2025
Air Force Medical University
2023-2025
Tongliao Academy of Agricultural Sciences
2023-2024
Children's Hospital of Fudan University
2024
Qilu Hospital of Shandong University
2023
Guangdong Medical College
2023
Henan Provincial People's Hospital
2023
China Medical University
2023
Tianjin Medical University General Hospital
2023
Affiliated Hospital of Guangdong Medical College Hospital
2023
Abnormal expression of miR-199a-3p, which has similar effects to oncogenes or tumor suppressor genes, can occur in various malignant tumors and is closely linked with cell proliferation, invasion, metastasis. However, its endometrial endometrioid adenocarcinoma (EEC) are still unclear. This study was designed identify the impact miR-199a-3p on proliferation EEC cells role carcinogenesis EEC.The levels paired adjacent nontumor tissues were analyzed by real-time polymerase chain reaction. The...
Abstract Halogenated carbazoles are increasingly identified as a novel class of environmental contaminants. However, no in vivo acute toxicity information on those compounds was available. In the present study, an zebrafish embryonic model ( Danio rerio ) used to investigate developmental halogenated carbazoles. The results suggested that structure‐dependent. Two 6 tested carbazoles, 2,7‐dibromocarbazole (27‐DBCZ) and 2,3,6,7‐tetrachlorocarbazole, showed obvious at nanomolar levels. typical...
Abstract Background The mechanism of hepatitis B virus (HBV)‐induced carcinogenesis remains an area interest. accumulation surface antigen in the endoplasmic reticulum (ER) hepatocytes stimulates persistent ER stress. Activity unfolded protein response (UPR) pathway stress may play important role inflammatory cancer transformation. How protective UPR is hijacked by cells as a tool for malignant transformation HBV‐related hepatocellular carcinoma (HCC) still unclear. Here, we aimed to define...
Background Deltamethrin (DM) is a broad-spectrum insecticide that widely used to control agricultural pests. Recently, DM has posed potential threat the health of infants and young children, this because environmental food pollution caused by extensive use DM. Methods In study, zebrafish ( Danio rerio ) embryos were as experimental animals quantify behavioral changes larvae induced explore relationship between acetylcholinesterase activity. Results The results showed an increase in coiling...
Cyclic amines serve as versatile building blocks in pharmaceuticals; however, their modification through enantioselective sp 3 C–H functionalization presents significant challenges. In this study, we present a one-pot photoenzyme cascade process...
ABSTRACT Anoikis resistance in hepatocellular carcinoma (HCC) cells boosts survival and metastasis. This study aimed to establish an anoikis‐related genes (ARGs)‐based model for predicting HCC patients’ outcomes investigate the clinicopathological significance function of crucial ARGs. The transcriptional expression patterns cohorts were compiled from TCGA, GEO ICGC. Univariate LASSO multivariate analyses performed screen prognostic Gain‐ loss‐of‐function studies, RNA sequencing, mass...
Abstract Background There is growing evidence supporting a role for microRNAs (miRNA) as targets in aberrant mechanisms of DNA hypermethylation. Epigenetic silencing tumor suppressor miRNAs, including miR-663, which has recently been reported to be inactivated by hypermethylation several cancers, may play important roles pediatric acute myeloid leukemia (AML). However, expression miR-663 and its promoter methylation remain status unclear childhood leukemia. Methods Promoter was investigated...
Melanoma is a serious malignant form of skin cancer. Euphorbiaceae compound B (ECB, 2,4-dihydroxy-6-methoxy-3-methylacetophenone) an acetophenone that isolated from Euphorbia ebracteolata Hayata (EEH), herbaceous perennial, and has antitumor activity. Here, we transplanted human melanoma cells into zebrafish embryos to establish zebrafish/melanoma model. We showed this model can be used evaluate the therapeutic effect EEH ECB discussed its potential mechanism action. The results was active...
Ferulic acid (FA) is one of a common ingredients in Chinese herbal medicine. FA has the interesting property promoting growth and improving meat quality livestock, but mechanism not understood. This study evaluated both safety efficacy zebrafish model. At 15 μg/mL or above, led to pericardial oedema delayed embryos. Dietary promoted feed assimilation male adult zebrafish. Genes related myogenic development (myod1, myog myf5) were significantly upregulated by muscle fibre width skeletal was...
Urtica cannabina L. (UL) has been used clinically for centuries because of its anti-inflammatory properties. This study aimed to investigate the underlying mechanisms and effects different UL concentrations in zebrafish. To elucidate UL’s properties, two inflammation zebrafish models were designed 1) by severing zebrafish’s caudal fin assess repairing effect on tail inflammation, 2) inducing lipopolysaccharides (LPS)-mediated intestinal protective reparative at histological genetic levels....
This study aims to uncover the function of long non-coding RNA (lncRNA) AWPPH in progression non-small cell lung cancer (NSCLC) and potential mechanism.AWPPH microRNA (miRNA-204) levels NSCLC tissues adjacent normal were detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Kaplan-Meier curves introduced for assessing overall survival patients expressing high or low level AWPPH. Potential correlation between expression miRNA-204 was analyzed Spearman test. Through...
Osteoarthritis (OA) is a chronic progressive degenerative joint disease. Owing to its complex pathogenesis, OA treatment typically challenging. Necroptosis form of programmed cell death mainly mediated by the serine/threonine kinases, RIPK1 and RIPK3, mixed lineage kinase-like domain (MLKL). In this study, we found that multi-targeted kinase inhibitor DCC-2036 can inhibit TSZ (TNF-α, Smac mimetic, z-VAD-FMK)-induced necroptosis chondrocytes synovial fibroblast cells (SFs). addition, oral...