A5020000785- Sleep and related disorders
- Neural and Behavioral Psychology Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Obesity, Physical Activity, Diet
- Genetic Associations and Epidemiology
- Sleep and Wakefulness Research
- Evolutionary Game Theory and Cooperation
- Psychological Well-being and Life Satisfaction
- Obstructive Sleep Apnea Research
- Social Sciences and Policies
- Perfectionism, Procrastination, Anxiety Studies
- Child and Adolescent Psychosocial and Emotional Development
- Evolutionary Psychology and Human Behavior
- Long-Term Effects of COVID-19
- Eating Disorders and Behaviors
- Cultural Differences and Values
- Personal Information Management and User Behavior
- Child Nutrition and Feeding Issues
- Mind wandering and attention
- Creativity in Education and Neuroscience
- Public Policy and Governance
- Public Health and Environmental Issues
- Psychology of Moral and Emotional Judgment
- Emotions and Moral Behavior
- Mental Health Research Topics
Universidad de la República
2017-2025
Massachusetts General Hospital
2024-2025
MRC Unit for Lifelong Health and Ageing
2021-2025
University College London
2021-2025
Harvard University
2024-2025
Comisión Sectorial de Investigación Científica
2024
University of Liverpool
2024
University of Groningen
2019
Universidad La República
2019
Netherlands Interdisciplinary Demographic Institute
2019
Importance Observational studies have associated anorexia nervosa with circadian rhythms and sleep traits. However, the direction of causality extent confounding by psychosocial comorbidities in these associations are unknown. Objectives To investigate association between traits through mendelian randomization to test a polygenic risk score (PRS) for disorders clinical biobank. Design, Setting, Participants This genetic study used bidirectional 2-sample summary-level (from Psychiatric...
Depression significantly affects interpersonal functioning.Social avoidance may play an important role in depression, limiting opportunities and social skills acquisition, contributing to the maintenance of difficulties.In last few years, need for studying interactions using interactive tasks has been highlighted.This study investigated unmedicated depressed (n ϭ 26) matched healthy control participants, a novel computerized decision-making task (the TEAM task).In this task, participants...
Daytime napping has been associated with cognitive function and brain health in observational studies. However, it remains elusive whether these associations are causal. Using Mendelian randomization, we studied the relationship between habitual daytime cognition structure.Data were from UK Biobank (maximum n = 378,932 mean age 57 years). Our exposure (daytime napping) was instrumented using 92 previously identified genome-wide, independent genetic variants (single-nucleotide polymorphisms,...
Recent genome-wide association studies (GWASs) of several individual sleep traits have identified hundreds genetic loci, suggesting diverse mechanisms. Moreover, are moderately correlated, so together may provide a more complete picture health, while illuminating distinct domains. Here we construct novel health scores (SHSs) incorporating five core self-report measures: duration, insomnia symptoms, chronotype, snoring, and daytime sleepiness, using additive (SHS-ADD) principal...
ABSTRACT Recent genome-wide association studies (GWASs) of several individual sleep traits have identified hundreds genetic loci, suggesting diverse mechanisms. Moreover, are moderately correlated, and together may provide a more complete picture health, while also illuminating distinct domains. Here we construct novel health scores (SHSs) incorporating five core self-report measures: duration, insomnia symptoms, chronotype, snoring, daytime sleepiness, using additive (SHS-ADD) principal...
Abstract Depression and social anxiety are common disorders that have a profound impact on functioning. The need for studying the neural substrates of interactions in mental using interactive tasks has been emphasized. field neuroeconomics, which combines neuroscience techniques behavioral economics multiplayer such as Ultimatum Game (UG), can contribute this direction. We assessed emotions, behavior, Event‐Related Potentials participants with depression and/or symptoms (MD/SA, n = 63, 57...
Abstract Social comparison is central in human life and can be especially challenging depression social anxiety. We assessed event‐related potentials emotions using a task which participants received feedback on both their own co‐player's performance, with and/or anxiety ( n = 63) healthy controls 72). Participants reported more negative for downward (being better than the co‐player [participant correct, wrong]) upward worse wrong, correct]) comparisons versus even outcomes, these effects...
The iterated prisoner’s dilemma (iPD) game is a well-established model for testing how people cooperate, and the neural processes that unfold after its distinct outcomes have been partly described. Recent theoretical models suggest evolution favors intuitive cooperation, which raises questions on behavioral but also timelines involved. We studied outcome/feedback stage of iPD rounds with electroencephalography (EEG) methods. Results showed signals associated this relate to future choice, in...
Sleep is a complex behavior regulated by genetic and environmental factors, known to influence health outcomes. However, the effect of multidimensional sleep encompassing several dimensions on diseases has yet be fully elucidated. Using Mass General Brigham Biobank, we aimed examine association with outcomes investigate whether behaviors modulate predisposition unfavorable mental First, generated Polygenic Health Score using previously identified single nucleotide polymorphisms for...
Abstract Increasing evidence links circadian and sleep disruptions with depression, though whether they are causally related remains unclear. This study used Mendelian randomization (MR) exposures instrumented using genome-wide genetic variants data from the UK Biobank (n=408 480; mean age=56.9 years) to explore causal associations between traits, depression. We conducted bidirectional MR analyses morningness, duration, insomnia symptoms, secondary unidirectional traits as mixed...
Abstract Social comparison is central in human life and can be especially challenging depression social anxiety. We assessed event-related potentials emotions when receiving feedback on both their own a co-player’s performance, participants with and/or anxiety (n=63) healthy controls (n=72). Participants reported more negative for downward (being better than someone else) upward worse) comparisons vs. even outcomes, these effects being stronger At the Medial Frontal Negativity, depressed...
Social difficulties are inherent to social anxiety and critical in depression. A key feature both disorders is avoidance, which leads the loss of opportunities precludes from improving abilities. The need for studying functioning using interactive tasks that immerse subject a context has been highlighted. We developed an task allows measuring avoidance. In each round, participants choose between two categories co-players, with kind partner they would like make team. material terms, it always...
Abstract Daytime napping has been associated with cognitive function and brain health in observational studies. However, it remains elusive whether these associations are causal. Using Mendelian randomisation (MR), we studied the relationship between habitual daytime cognitive/structural outcomes. Data were from UK Biobank (UKB) (maximum n = 378 932; mean age= 57 years). Our exposure (daytime napping) was instrumented using 92 previously identified genome-wide, independent genetic variants...
BACKGROUND: Numerous studies have reported high rates of depressive and anxiety symptoms related to the COVID-19 crisis measures implemented contain virus spread. Even though restrictive such as mandatory lockdown were not applied in Uruguay, mental health could be affected. Moreover, sociodemographic lifestyle factors modulate this impact. We aimed evaluate impact pandemic on among Uruguayan people examine associated factors.METHODS: This study was conducted a non-probabilistic sample 1051...
Abstract Electing whether to cooperate with someone else is well typified in the iterated prisoner’s dilemma (iPD) game, although neural processes that unfold after its distinct outcomes have been only partly described. Recent theoretical models emphasize ubiquity of intuitive cooperation, raising questions on timelines involved. We studied outcome stage an iPD electroencephalography (EEG) methods. Results showed signals are modulated by can also be indicative future choice,...