A5107986564- Transplantation: Methods and Outcomes
- Phagocytosis and Immune Regulation
- Global Cancer Incidence and Screening
- Cardiac Fibrosis and Remodeling
- COVID-19 Impact on Reproduction
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- Renal Transplantation Outcomes and Treatments
- Tissue Engineering and Regenerative Medicine
- Medical Imaging and Pathology Studies
- Cardiac Structural Anomalies and Repair
- Congenital Anomalies and Fetal Surgery
- Cardiovascular Syncope and Autonomic Disorders
- COVID-19 Clinical Research Studies
- Cell Adhesion Molecules Research
- Economic and Financial Impacts of Cancer
- Mechanical Circulatory Support Devices
- Cardiac Arrhythmias and Treatments
- Autoimmune and Inflammatory Disorders Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Kawasaki Disease and Coronary Complications
- Electrospun Nanofibers in Biomedical Applications
- Soft tissue tumor case studies
- Immune cells in cancer
University of Florida
2021-2024
University of Florida Health
2022-2024
UF Health Cancer Center
2024
Florida College
2023
Mater Misericordiae University Hospital
2016
Patients with end stage lung diseases require transplantation (LTx) that can be impeded by ischemia-reperfusion injury (IRI) leading to subsequent chronic allograft dysfunction (CLAD) and inadequate outcomes.
Abstract The rising incidence of non-ST-segment elevation myocardial infarction (NSTEMI) and associated long-term high mortality constitutes an urgent clinical issue. Unfortunately, the study possible interventions to treat this pathology lacks a reproducible pre-clinical model. Indeed, currently adopted small large animal models MI mimic only full-thickness, ST-segment-elevation (STEMI) infarcts, hence cater for investigation into therapeutics directed at subset MI. Thus, we develop ovine...
Persistent sinus tachycardia (pST) has been associated with adverse cardiovascular events in critically ill patients. Pharmacological control of heart rate negative inotropic agents proven to be safe but could potentially dangerous patients concomitant right ventricular (RV) dysfunction. Ivabradine, a medication devoid inotropy, solution for this patient population when adequate is desired. A 17-year-old male history vaping developed acute respiratory distress syndrome (ARDS) and RV...
Macrophage activating syndrome (MAS) is a form of hemophagocytic lymphohistiocytosis (HLH), rare complication autoimmune disease that characterized by cytokine storm and multiorgan failure.A 32-year-old male presented with acutely decompensated pulmonary arterial hypertension right heart failure secondary to MAS. The patient was immediately started on inhaled intravenous epoprostenol, vasopressors dexamethasone anakinra were administered. Despite the therapies given, patient's condition...
Lung transplantation (LTx) outcomes are impeded by ischemia/reperfusion injury (IRI) and subsequent chronic lung allograft dysfunction (CLAD). We examined the undefined role of receptor Mer tyrosine kinase (MerTK) on monocytic myeloid-derived suppressor cells (M-MDSCs) in efferocytosis to facilitate resolution IRI. Single-cell RNA sequencing tissue bronchoalveolar lavage (BAL) from patients after LTx were analyzed. Murine hilar ligation allogeneic orthotopic models IRI used with BALB/c (WT),...
Belatacept is a novel T-cell costimulation blockade agent that has unresolved controversy in lung transplant recipients. been recognized as calcineurin sparing for solid organ recipients after reported success renal patients, despite limited evidence other We present the first case of recipient receiving Belatacept, combination with low dose inhibitor, who developed progressive multifocal leukoencephalopathy. While without inhibitor associated increased risk acute rejection recipients, its...
This case discusses the diagnosis and management of pulmonary sequestration. Typically discovered incidentally on imaging, it can be a cause recurrent infections causing severe morbidity to patient. Surgical is indicated when found prevent complications infections, including necrosis, abscess, or fistula formation.
Event Abstract Back to Towards an elastin-based hydrogel platform for the repair of myocardial infarction Paolo Contessotto1, Gesmi Milcovich1*, Renza Spelat1*, Grazia Marsico1*, Ankit Chaturvedi2*, Doriana Orbanić3*, Tatjana Flora3*, Mark Da Costa1, 4, Mindaugas Rackauskas5*, Heinz Amenitsch6*, Mike Mccartin2*, José Carlos Rodriguez-Cabello3*, Lokesh Joshi7*, Peter Dockery8*, Michelle Kilcoyne7, 9* and Abhay Pandit1 1 National University Ireland, CURÁM, Centre Research in Medical Devices,...
Aims We aim to outline a three year review of consecutive mitral valve surgeries performed by single surgeon. further establish the predictability repair in degenerative population. Methods All patients who underwent isolated or combined surgery from January 2013 April 2016 had their pre operative echocardiograph and note reviewed. In cases disease this data was reviewed compare predicted rates actual rates. Results 181 surgery. Underlying pathologies were as follows; 57% (n = 103),...
Pulmonary nodules often present a diagnostic challenge due to their diverse etiology, ranging from benign malignant conditions. We discuss the journey of 71-year-old female patient with history kidney stones, who was incidentally found have pleural-based pulmonary nodule during CT urogram. Subsequent imaging showed growth, prompting further investigations, including PET/CT scan and CT-guided biopsy, which yielded inconclusive results. A multidisciplinary approach recommended surgical...
Abstract The rising incidence of non-ST-segment elevation myocardial infarction (NSTEMI) and associated long-term high mortality constitutes an urgent clinical issue. Unfortunately, the study possible interventions to treat this pathology lacks a reproducible pre-clinical model. Indeed, currently adopted small large animal models MI mimic only full-thickness, ST-segment-elevation (STEMI) infarcts, hence cater for investigation into therapeutics directed at subset MI. Thus, we developed ovine...