A5014363449- Cardiac Fibrosis and Remodeling
- Tissue Engineering and Regenerative Medicine
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Peptidase Inhibition and Analysis
- Electrospun Nanofibers in Biomedical Applications
- Infective Endocarditis Diagnosis and Management
- Acute Kidney Injury Research
- Head and Neck Cancer Studies
- Cell Adhesion Molecules Research
- Antimicrobial agents and applications
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Vascular Procedures and Complications
- Central Venous Catheters and Hemodialysis
- Polymer Surface Interaction Studies
- Cardiac Arrhythmias and Treatments
- Infectious Aortic and Vascular Conditions
- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Wound Healing and Treatments
- Metal and Thin Film Mechanics
- Surgical Sutures and Adhesives
University Hospital Galway
2013-2023
Ollscoil na Gaillimhe – University of Galway
2021-2022
National University Hospital
2007
Ischemic heart disease is a leading cause of mortality due to irreversible damage cardiac muscle. Inspired by the post-ischemic microenvironment, we devised an extracellular matrix (ECM)-mimicking hydrogel using catalyst-free click chemistry covalent bonding between two elastin-like recombinamers (ELRs). The resulting customized included functional domains for cell adhesion and protease cleavage sites, sensitive metalloproteases overexpressed after myocardial infarction (MI). scaffold...
A novel mussel-inspired adhesive can bond well to the surface of wet bone and be programmed set in a suitable manner for sternal closure applications. With good adhesion properties, low exothermic biodegradability toxicity, we believe that this technology, which further built upon modified, will endow intriguing potential closure.
Cardiac surgery remains the gold standard treatment for select cohorts of patients with coronary artery and valvular heart diseases. It induces an acute systemic inflammatory response due to cardiopulmonary bypass (CPB), myocardial arrest, surgical trauma. There is growing evidence that increased inflammation leads greater complications poorer outcomes post cardiac surgery. Neutrophil/lymphocyte ratio (NLR) a promising marker inflammation. This study assessed if NLR could predict...
Abstract The rising incidence of non-ST-segment elevation myocardial infarction (NSTEMI) and associated long-term high mortality constitutes an urgent clinical issue. Unfortunately, the study possible interventions to treat this pathology lacks a reproducible pre-clinical model. Indeed, currently adopted small large animal models MI mimic only full-thickness, ST-segment-elevation (STEMI) infarcts, hence cater for investigation into therapeutics directed at subset MI. Thus, we develop ovine...
Abstract Bioadhesives are revolutionizing wound closure procedures. However, traditional bioadhesives lack functions to promote healing with a higher dehiscence rate than those treated sutures. As result, creating multifunctional improve and facilitate care is extremely desirable in clinical settings. This study develops series of using succinic anhydride‐modified hyaluronic acid (HASA) plant‐derived tannic (TA) centrifuging freeze‐drying. By varying the ratio HASA TA, HASATA 1:2, 1:7, 1:14...
We present a case of young woman who was initially diagnosed with acute stroke no obvious risk factors. Preliminary investigation transthoracic echocardiography and subsequent advanced imaging transoesophageal suggested the diagnosis benign cardiac tumour on anterior leaflet mitral valve. The patient underwent urgent surgical resection. Histology confirmed papillary fibroelastoma. She made complete clinical recovery recurrence symptoms.
Transcatheter aortic valve implantation (TAVI) has emerged as the standard of care for older patients with symptomatic severe stenosis (AS) at high or excessive operative risk. There remain that are such considerable risk even TAVI can be futile. Such present ethical conundrums institutional heart teams. Herein we a case 90-year-old female patient AS and significant comorbidities including diffuse peripheral vascular disease large ascending aneurysm. Would utile futile in this patient?
Surgical revascularization in patients with coronary artery disease and severe left ventricular dysfunction is a common practice poses surgical challenge. From September 2002 to May 2004, 50 (47 men 3 women; mean age, 59 ± 9 years) preoperative ejection fraction of 19.7% 3.2% underwent revascularization. The EuroSCORE was 7.2 3.4. Indications for surgery were congestive heart failure 8 (16%), angina 20 (40%), arrhythmias 4 (8%), critical main stem 12 (24%). Twenty-two (44%) had emergency...
<h3></h3> Heart failure caused by myocardial infarction (MI) is a burgeoning clinical problem. The modulation of post-ischemic remodelling after MI may ameliorate the deleterious effect on cardiac function. Elastin main component ECM and has critical functions in vasculature structures. We hypothesized that an elastin-like recombinamer-based (ELRs) hydrogel could benefit ovine model MI. A novel was developed to mimic patchy regional often seen at coronary revascularization surgery early...
Abstract The rising incidence of non-ST-segment elevation myocardial infarction (NSTEMI) and associated long-term high mortality constitutes an urgent clinical issue. Unfortunately, the study possible interventions to treat this pathology lacks a reproducible pre-clinical model. Indeed, currently adopted small large animal models MI mimic only full-thickness, ST-segment-elevation (STEMI) infarcts, hence cater for investigation into therapeutics directed at subset MI. Thus, we developed ovine...
<h3>Background</h3> Modulation of post-ischaemic remodelling is a significant clinical need.<sup>1</sup> Ischaemia results in the loss millions living cells as result hypoxic condition.<sup>1</sup> However, our tissue programmed to compensate for this by activating program which leads formation fibrotic scar.<sup>1</sup> Inspired natural extracellular matrix, we have developed an injectable elastin-based hydrogel showed marked functional and biological improvements ischaemic hearts using...
Radial artery pseudoaneurysm is a rare complication of radial cannulation, with underlying infection rarer still. A formed when there exsanguination, secondary to penetrating injury between the two outer layers an artery: muscularis propria and adventitia. We report case infected pseudomonas aeruginosa in 73-year-old male who had cannulation for perioperative monitoring during coronary bypass grafting.