A5089665448- Nanoparticle-Based Drug Delivery
- Surgical Sutures and Adhesives
- Advanced Drug Delivery Systems
- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Nanoplatforms for cancer theranostics
- Wound Healing and Treatments
- Ear Surgery and Otitis Media
- Proteoglycans and glycosaminoglycans research
- Hemostasis and retained surgical items
- Polymer-Based Agricultural Enhancements
- Nanocomposite Films for Food Packaging
- Tissue Engineering and Regenerative Medicine
- Fibroblast Growth Factor Research
- Electrochemical sensors and biosensors
- Electrospun Nanofibers in Biomedical Applications
- Osteoarthritis Treatment and Mechanisms
- Intestinal and Peritoneal Adhesions
- Cannabis and Cannabinoid Research
- Plant Growth Enhancement Techniques
- RNA Interference and Gene Delivery
- Legume Nitrogen Fixing Symbiosis
- Silk-based biomaterials and applications
- Glycosylation and Glycoproteins Research
- Advancements in Transdermal Drug Delivery
University of the Basque Country
2022-2025
University Hospital Galway
2022-2025
Polymat
2024
Ollscoil na Gaillimhe – University of Galway
2021-2022
Instituto de Ciencia y Tecnología de Polímeros
2017-2018
Hospital Universitario Puerta de Hierro Majadahonda
2016-2017
Consejo Superior de Investigaciones Científicas
2017
Intrauterine adhesion (IUA) is the fibrosis within uterine cavity. It second most common cause of female infertility, significantly affecting women's physical and mental health. Current treatment strategies fail to provide a satisfactory therapeutic outcome for IUA patients, leaving an enormous challenge reproductive science. A self-healing adhesive hydrogel with antioxidant properties will be highly helpful in prevention. In this work, we prepare series hydrogels (P10G15, P10G20, P10G25)...
Abstract The inorganic content and the catalytic performance pose metal‐loaded enzyme nanoflowers as promising candidates for developing bioelectrodes capable of functioning without external addition a redox mediator. However, these protein‐inorganic hybrids have yet to be successfully applied in combination with electrode materials. Herein, synthesis procedure bionanomaterials is reproposed precisely control morphology, composition, this particular protein‐mineral hybrid, formed by glucose...
HAS2 mediated hyaluronic acid (HA) synthesis is overexpressed in the cortex after a neuroinflammatory insult creating an extracellular matrix (ECM) scar. This ameliorated treatment with HA hydrogel through its antiinflammatory effect and ECM remodelling ability.
More than 90% of drug candidates used in the development pipeline and about 40% drugs market are poorly soluble water based on definition of...
Abstract Shape memory sponges are very promising in stopping the bleeding from noncompressible and narrow entrance wounds. However, few shape have fast degradable properties order to not hinder tissue healing. In this work, based on cryopolymerization, a succinic ester‐based sponge (Ssponge) is fabricated using gelatin bi‐polyethylene glycol‐succinimidyl succinate (Bi‐PEG‐SS). Compared with commercially available (Csponge), Ssponge possesses better water/blood absorption ability higher...
Cannabidiol (CBD) is the most relevant nonpsychostimulant phytocompound found in Cannabis sativa. CBD has been extensively studied and proposed as a therapeutic candidate for neuroinflammation-related conditions. However, being highly lipophilic drug, it several drawbacks pharmaceutical use, including low solubility high permeability. Synthetic polymers can be used drug delivery systems to improve CBD's stability, half-life, biodistribution. Here, we propose using synthetic polymer...
Epidural adhesion or epidural fibrosis is the major reason for postoperative pain, which remains a clinically challenging problem. Current physical barriers fail to provide satisfactory therapeutic outcome mainly due their lack of adhesion, inability prevent fluid leakage, and exhibiting limited antioxidant properties. Herein, we fabricated cysteine-modified bioadhesive (SECAgel) with improved sealing properties prevention, inspired by organism's systems. The resulting SECAgel showed good...
Improving the root system architecture (RSA) under adverse environmental conditions by using biostimulants is emerging as a new way to boost crop productivity. Recently, we have reported characterization of novel chitosan-based microparticles (CS-MPs) with promising biological properties rooting agents in lettuce. In this work, demonstrated that contrast bulk chitosan (CS), which exerts growth inhibition, CS-MPs promoted and development from 1 10 μg mL–1 without cytotoxicity effects at...
Nanocrystals (NCs) have entirely changed the panorama of hydrophobic drug delivery, showing improved biopharmaceutical performance through multiple administration routes. NCs are potential highly loaded nanovectors due to their pure composition, standing out from conventional polymers and lipid nanoparticles that limited drug-loading capacity. However, research in this area is limited. This study introduces concept surface modification single-layer poly(ethylene glycol) (PEG) polymerization...
We provide evidence for the presence of cannabinoid CB2 receptors in some cellular types cochlea adult albino rat. Cannabinoids and their are increasingly being studied because high potential clinical use. As a hyperspecialized portion peripheral nervous system, study expression function hearing organ is interest. Stria vascularis inner hair cells express receptor, as well neurites cell bodies spiral ganglion. Cellular such supporting outer cells, which other functional has been reported, do...
Abstract Bioadhesives are revolutionizing wound closure procedures. However, traditional bioadhesives lack functions to promote healing with a higher dehiscence rate than those treated sutures. As result, creating multifunctional improve and facilitate care is extremely desirable in clinical settings. This study develops series of using succinic anhydride‐modified hyaluronic acid (HASA) plant‐derived tannic (TA) centrifuging freeze‐drying. By varying the ratio HASA TA, HASATA 1:2, 1:7, 1:14...
The ability of the zebrafish heart to regenerate following injury makes it a valuable model deduce why this capability in mammals is limited early neonatal stages. Although metabolic reprogramming and glycosylation remodeling have emerged as key aspects many biological processes, how they may trigger cardiac regenerative response still crucial question. Here, by using an up-to-date panel transcriptomic, proteomic glycomic approaches, we identify switch from mitochondrial oxidative...