A5004534009- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Effects of Exercise
- ECG Monitoring and Analysis
- Ion channel regulation and function
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Cardiac tumors and thrombi
- Genetic Neurodegenerative Diseases
- Ultrasound and Hyperthermia Applications
- Cardiomyopathy and Myosin Studies
- Vascular Malformations and Hemangiomas
- Analog and Mixed-Signal Circuit Design
- Cardiac Structural Anomalies and Repair
- Vascular Tumors and Angiosarcomas
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Valve Diseases and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Health and Medical Studies
Amsterdam University Medical Centers
2018-2024
University of Amsterdam
2018-2024
Amsterdam UMC Location University of Amsterdam
2020-2023
University of Lausanne
2023
Duran i Reynals Hospital
1996
Abstract Aims Stereotactic arrhythmia radiotherapy (STAR) is suggested as potentially effective and safe treatment for patients with therapy-refractory ventricular tachycardia (VT). However, the current prospective knowledge base experience STAR limited. In this study we aimed to prospectively evaluate efficacy safety of STAR. Methods results The StereoTactic Arrhythmia Radiotherapy in Netherlands no.1 was a pre-post intervention VT, pro-arrhythmic region treated 25 Gy single fraction. main...
Cardiac radioablation has evolved as a potential treatment modality for therapy-refractory ventricular tachycardia. To standardize cardiac treatments, promote accurate communication and target identification, to assess toxicity, robust, reproducible methods angulation segmentation are paramount. In this study, we developed evaluated tool semiautomated according the American Heart Association 17-segment model.
Patients with Brugada syndrome (BrS) can show a leftward deviation of the frontal QRS-axis upon provocation sodium channel blockers. The cause this axis change is unclear. In study, we aimed to determine (1) prevalence left and (2) evaluate its cause, using insights that could be derived from vectorcardiograms. Hence, large cohort patients who underwent ajmaline testing (n = 1430), selected in whom type-1 BrS-ECG was evoked 345). Depolarization repolarization parameters were analyzed for...
The genetic risk haplotype DPP6 has been linked to familial idiopathic ventricular fibrillation (IVF), but the associated long-term outcomes are unknown.DPP6 haplotype-positive family members (DPP6 cases) and their haplotype-negative relatives controls) were included. Clinical follow-up data collected through March 2023. Implantable cardioverter-defibrillator (ICD) indication was divided in primary or secondary prevention. Cumulative survival event rates calculated.We included 327 cases 315...
Abstract Aims During the diagnostic work-up of patients with idiopathic ventricular fibrillation (VF), next-generation sequencing panels can be considered to identify genotypes associated arrhythmias. However, consensus for gene panel testing is still lacking, and variants uncertain significance (VUS) are often identified. The aim this study was evaluate genetic its results in VF patients. Methods We investigated 419 available medical records from Dutch Idiopathic Registry. Genetic performed...
Mexiletine is a long-known drug used for the treatment of arrhythmias and repurposed in 1980s patients with nondystrophic myotonia (NDM). Recently, price mexiletine Europe increased significantly after registration as an orphan NDM. This led to international discussions on affordability willingness reimburse absence background information that would justify such price. Our objective was calculate cost-based adult NDM based detailed development costs.We calculated fair pricing model...
Background Cardiac sarcoidosis is associated with heart failure, conduction abnormalities, and life-threatening arrhythmias including ventricular tachycardia (VT). Radiotherapy has been suggested as a treatment for extra-cardiac in patients refractory to immunomodulatory treatment. Methods The effectiveness safety of low-dose whole-heart radiotherapy therapy cardiac were evaluated pre- post-intervention case report comparing the 54 months before after Immunomodulatory irradiation consisted 2...
Background Stereotactic arrhythmia radioablation (STAR) is a potential new therapy for patients with refractory ventricular tachycardia (VT). The arrhythmogenic substrate (target) synthesized from clinical and electro-anatomical information. This study was designed to evaluate the baseline interobserver variability in target delineation STAR. Methods Delineation software research purposes used. split into three phases. Firstly, electrophysiologists delineated well-defined structure (spinal...
Stereotactic arrhythmia radioablation (STAR) appears to be beneficial in selected patients with therapy-refractory ventricular tachycardia (VT). However, high-dose radiotherapy used for STAR-treatment may affect functioning of the patients' implantable cardioverter defibrillator (ICD) by direct effects radiation on ICD components or cardiac tissue. Currently, effect STAR remains unknown.A retrospective pre-post multicenter study evaluating 12-month before and after was performed. Patients...
Abstract Aims In patients with Brugada syndrome (BrS) but without spontaneous Type-1 electrocardiogram, several electrocardiographic characteristics have been studied, including the β-angle. Previous studies suggested that β-angle might be useful in distinguishing BrS-patients from only suggestive repolarization patterns performing sodium channel blocker provocation testing. this study, we aimed to determine diagnostic value of suspected BrS. Methods and results A large cohort (n = 1430)...