A5102854703- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiovascular and exercise physiology
- Cardiac tumors and thrombi
- Heart Rate Variability and Autonomic Control
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Hemodynamic Monitoring and Therapy
- Cardiovascular Syncope and Autonomic Disorders
- Acute Myocardial Infarction Research
- Health Systems, Economic Evaluations, Quality of Life
- Genetic Neurodegenerative Diseases
- Cardiac Valve Diseases and Treatments
- Congenital Diaphragmatic Hernia Studies
- ATP Synthase and ATPases Research
- Medical Research and Practices
- Ultrasound in Clinical Applications
- Muscle Physiology and Disorders
- Olfactory and Sensory Function Studies
- Coenzyme Q10 studies and effects
James Cook University Hospital
2013-2025
South Tees Hospitals NHS Foundation Trust
2013-2024
Khalifa University of Science and Technology
2024
Cardiff Metropolitan University
2022
The Royal Melbourne Hospital
2015-2019
Newcastle University
2010-2017
Newcastle upon Tyne Hospital
2016
Wellcome Centre for Mitochondrial Research
2011-2015
Freeman Hospital
2013-2014
Newcastle upon Tyne Hospitals NHS Foundation Trust
2013
Mitochondrial (mt) DNA depletion and oxidative mtDNA damage have been implicated in the process of pathological cardiac remodeling. Whether these features are present early phase maladaptive remodeling, that is, during compensated hypertrophy, is still unknown. We compared morphologic molecular mt biogenesis markers stress human heart from adult subjects with hypertrophic cardiomyopathy failure. shown a constant feature both conditions. A quantitative loss content was associated significant...
Background Options for patients with ventricular tachycardia (VT) refractory to antiarrhythmic drugs and/or catheter ablation remain limited. Stereotactic radiotherapy has been described as a novel treatment option. Methods Seven recurrent VT, deemed high risk either first time or redo invasive ablation, were treated across three UK centres non-invasive cardiac stereotactic ablative (SABR). Prior data and mapping combined cross-sectional imaging generate plans aim deliver single 25 Gy...
Bronchopulmonary dysplasia (BPD) is a common outcome of preterm birth. Experimental animal work has shown that initial ventilation strategies injure the immature lung and may lead to BPD. Studies with asphyxiated babies have that, if tidal at birth preceded by sustained inflation, larger inflation volumes can be achieved, which thought clearance fluid formation functional residual capacity (FRC).To see resuscitation would facilitate removal fluid, establish FRC, allow an even distribution...
ABSTRACT Background Atrial fibrillation (AF) and dementia are increasingly prevalent in aging US populations. Their association raises public health concerns, emphasizing the need to understand mortality trends older adults. This study examines AF dementia‐related from 2000 2020. Methods Using CDC WONDER Multiple Cause of Death database, we analyzed death certificates for individuals aged 65 older, reporting age‐adjusted rates (AAMRs) per 100 000 persons. Trends were assessed through annual...
We aimed to compare cryoballoon pulmonary vein isolation (PVI) with standard radiofrequency cavotricuspid isthmus (CTI) ablation as first-line treatment for typical atrial flutter (AFL).Cryoballoon Pulmonary Vein Isolation First-Line Treatment Typical Atrial Flutter was an international, multicentre, open blinded assessment trial. Patients CTI-dependent AFL and no documented fibrillation (AF) were randomised either PVI alone or CTI ablation. Primary efficacy outcome time first recurrence of...
Abstract Background CRAFT was an international, multicentre, randomised controlled trial across 11 sites in the United UK and Switzerland. Given evidence that pulmonary vein triggers may be responsible for atrial flutter (AFL) as well fibrillation (AF), we hypothesised cryoballoon isolation (PVI) would provide greater symptomatic arrhythmia reduction than cavotricuspid isthmus (CTI) ablation, whilst also reducing subsequent burden of AF. Twelve-month outcomes were previously reported. In...
Objective Exercise intolerance is a clinical hallmark of chronic conditions. The present study determined pathophysiological mechanisms exercise in cardiovascular, neuromuscular, and metabolic disorders. Methods In prospective cross-sectional observational 152 patients (heart failure reduced ejection fraction, n=32; stroke, n=34; mitochondrial disease, n=28; type two diabetes, healthy controls, n=30) performed cardiopulmonary testing with haemodynamic measurements. Peak O 2 consumption...
Objective Diminished cardiac high-energy phosphate metabolism (phosphocreatine-to-ATP (PCr:ATP) ratio) and power with age may play an important roles in development of dysfunction heart failure. The study defines the impact on PCr:ATP ratio their relationship. Methods Thirty-five healthy women (young≤50 years, n=20; old≥60 n=15) underwent MRI 31 P spectroscopy to assess performed maximal graded cardiopulmonary exercise testing simultaneous gas-exchange central haemodynamic measurements. Peak...
The use of pacemakers in the treatment cardioinhibitory vasovagal syncope is controversial with a mixed message from limited evidence base. Single chamber leadless have been shown to be an effective alternative option conventional pacemakers. This study examines population United Kingdom. Observational data on 32 patients implanted Micra Transcatheter Pacemaker System for are presented. Data was collected implant indications, procedure and follow up 12 centres across Kingdom that had elected...
Summary Purpose This study assessed the agreement between cardiac output estimated by inert gas rebreathing and bioreactance methods at rest during exercise. Methods Haemodynamic measurements were in 20 healthy individuals (11 females, nine males; aged 32 ± 10 years) using methods. Gas exchange haemodynamic data measured simultaneously under different stages (i.e. 30, 60, 90, 120, 150 180 W) of progressive graded cardiopulmonary exercise stress testing a bicycle ergometer. Results At rest,...
The autoimmune liver disease primary biliary cirrhosis (PBC) is associated with life-altering fatigue in ∼50% of patients. Previous work suggests that fatigued PBC subjects have evidence autonomic dysfunction and may be at a higher risk sudden cardiac death. manifestation this not clear. This pilot study investigated whether alterations torsion strain could detected or nonfatigued early-stage We performed tissue tagging anatomical cine-imaging 13 patients (including 7 significant fatigue) 10...
Background Stereotactic arrhythmia radioablation (STAR) is a potential new therapy for patients with refractory ventricular tachycardia (VT). The arrhythmogenic substrate (target) synthesized from clinical and electro-anatomical information. This study was designed to evaluate the baseline interobserver variability in target delineation STAR. Methods Delineation software research purposes used. split into three phases. Firstly, electrophysiologists delineated well-defined structure (spinal...
Age and physical inactivity are important risk factors for cardiovascular mortality. Heart rate response to exercise (HRRE) heart recovery (HRR), measures of cardiac autonomic function, strong predictors The present study defined the effect age activity on HRRE HRR. Healthy women (N=72) grouped according (young, 20-30 years; middle, 40-50 older, 65-81 years) daily (low active <7500, high >12,500 steps/day) performed a maximal cardiopulmonary test. was as an increase in from rest 1, 3 5...
Stereotactic arrhythmia radioablation (STAR) appears to be beneficial in selected patients with therapy-refractory ventricular tachycardia (VT). However, high-dose radiotherapy used for STAR-treatment may affect functioning of the patients' implantable cardioverter defibrillator (ICD) by direct effects radiation on ICD components or cardiac tissue. Currently, effect STAR remains unknown.A retrospective pre-post multicenter study evaluating 12-month before and after was performed. Patients...
Abstract Atrial fibrillation ( AF ) is the most common sustained cardiac arrhythmia and associated with significant morbidity mortality. Coronary artery disease CAD frequently coexists , management of these conditions can be challenging. Bleeding risks different combinations evidence‐based antithrombotic regimes need to considered effects medical therapies for or may impact on other condition. This article reviews current guidance consensus statements ESC . The principles in context are...
The present study evaluated reproducibility of the inert gas rebreathing method to estimate cardiac output at rest and during cardiopulmonary exercise testing. Thirteen healthy subjects (10 males, 3 females, ages 23-32 years) performed maximal graded stress test using a cycle ergometer on 2 occasions (Test 1 Test 2). Participants cycled 30-watts/3-min increments until peak exercise. Hemodynamic variables were assessed different intensities (i. e., 60, 120, 150, 180 watts) an technique....