A5018615145- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Pickering emulsions and particle stabilization
- Neonatal Respiratory Health Research
- Nanoparticles: synthesis and applications
- Complement system in diseases
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Photodynamic Therapy Research Studies
- Inhalation and Respiratory Drug Delivery
- Transgenic Plants and Applications
- Photoacoustic and Ultrasonic Imaging
- Erythrocyte Function and Pathophysiology
- Thermography and Photoacoustic Techniques
- Proteins in Food Systems
- Antiplatelet Therapy and Cardiovascular Diseases
- Injury Epidemiology and Prevention
- Nutrition and Health in Aging
- Supramolecular Self-Assembly in Materials
- Porphyrin and Phthalocyanine Chemistry
- Biosensors and Analytical Detection
- Inflammatory Biomarkers in Disease Prognosis
- Pesticide and Herbicide Environmental Studies
National Cancer Institute
2022-2024
National Institutes of Health
2022-2023
George Mason University
2012-2022
Institute for Advanced Study
2012-2017
University of Fairfax
2017
Brigham and Women's Hospital
2009-2012
Harvard University
2009-2012
Harvard–MIT Division of Health Sciences and Technology
2011
Massachusetts Institute of Technology
2009-2010
University of Oxford
2005-2008
The use of herbicides plays a vital role in controlling weeds and conserving crops; however, its usage generates both environmental economic problems. For example, pose financial issue as farmers must apply large quantities to protect crops due absorption rates less than 0.1%. Therefore, there is great need for the development new methods mitigate these issues. Here, we report first time synthesis poly(lactic-co-glycolic-acid) (PLGA) nanoherbicides loaded with atrazine an active ingredient....
Abstract The older American population is rapidly increasing, and millions of adults will be cancer survivors with comorbidities. This faces specific challenges regarding treatment has unique clinical needs. Recognizing this need, the National Cancer Institute, in collaboration Institute on Aging, hosted a webinar series, entitled Cancer, Comorbidities. commentary provides reflection 5 thematic areas covered by which was focused improving for comorbidities: 1) impact comorbidities...
We report the effect of chemical modification multi-walled carbon nanotubes (MWNTs) on their activation human serum complement system, as well adsorption plasma proteins MWNTs. Four different types chemically-modified MWNTs were tested for via classical and alternative pathways using haemolytic assays. Human protein binding was also an affinity chromatography technique based nanotube-Sepharose matrix. Covalent functionalization greatly altered level system pathway. For example,...
Mitochondria are sentinel organelles that impacted by various forms of cellular stress, including viral infections. While signaling events associated with mitochondria, those activated pathogen molecular patterns (PAMPs), widely studied, alterations in mitochondrial distribution and changes dynamics also beginning to be insult. Cells neuronal origin have been demonstrated display remarkable several instances, neurodegenerative disorders. Venezuelan Equine Encephalitis Virus (VEEV) is a New...
One of the primary challenges in breast cancer diagnosis and treatment is intratumor heterogeneity (ITH), i.e., coexistence different genetically epigenetically distinct malignant cells within same tumor. Thus, identification ITH critical for designing better treatments hence to increase patient survival rates. Herein, we report a noninvasive hybrid imaging technology that integrates multitargeted multiplexed patchy polymeric photoacoustic contrast agents (MTMPPPCAs) with single-impulse...
Carbon nanotubes (CNTs) did not exhibit strong interactions with Biliverdin IX beta reductase enzyme (BVRB) in water. With the use of noncovalent functionalization by surfactant Triton X-100, surfaces CNTs were changed from hydrophobic to hydrophilic. The hydrophilic surface CNT-Triton conjugate interacts BVRB, thus creating a water-soluble complex. Results ultracentrifugation through sucrose gradient and gel electrophoresis show presence enzyme. Raman spectroscopy confirmed that indeed conjugates.
Carbon nanotubes (CNTs) are increasingly being developed for use in biomedical applications, including drug delivery. One of the most promising applications under evaluation is treating pulmonary diseases such as tuberculosis. Once inhaled or administered, nanoparticles likely to be recognised by innate immune molecules lungs hydrophilic surfactant proteins. Here, we set out examine interaction between protein D (SP-D), a key lung pattern recognition molecule and CNTs, possible downstream...
Amide derivatives of L-alanine and ε-caprolactam were readily obtained on diamine-functionalized oxidized single-walled pristine multi-walled carbon nanotubes through a one-step direct amidation reaction, which employs thermal activation at 160–200 °C instead chemical activation, avoids the use organic solvents, requires few hours only for completion. In case ε-caprolactam, amino groups attached to initiated polymerization into Nylon 6. The functionalized characterized by infrared Raman...
Currently, several challenges prevent poly(lactic-co-glycolic acid) (PLGA) particles from reaching clinical settings. Among these is a lack of understanding the molecular mechanisms involved in formation particles. We have been studying depth patchy polymeric These are made PLGA and lipid–polymer functional groups. They unique patch–core–shell structural features: hollow or solid hydrophobic cores surface. Previously, we identified shear stress as most important parameter particle's...
Spontaneous formation of heterogeneous patches on the surface lipid-based nanoparticles (NPs) and microparticles (MPs) due to segregation two different functional groups. Patch is observed when tracing groups with quantum dots, gold nanoparticles, fluorescent dyes. This discovery could have important implications for future design self-assembled NPs MPs biomedical applications.
The complement system can interact with nanoparticles and alter the intended therapeutic targeting.
Patchy polymeric particles have anisotropic surface domains that can be remarkably useful in diverse medical and industrial fields because of their ability to simultaneously present two different chemistries on the same construct. In this article, we report mechanisms involved formation novel lipid-polymeric hollow patchy during synthesis. By cross-sectioning particles, found a phase segregation phenomenon occurs between core, shell, patch. Importantly, shear stress polymer blend undergoes...