Clinical decision-making involves ethical issues that become more and complex. Nurse interns must be skilled in making rational timely decisions when facing dilemmas. The contributing factors their relationships challenge among nurse fully understood, as this level of knowledge can support the development strategies interventions improve ability interns.This study examined between moral courage, sensitivity, by interns. In addition, we investigated whether sensitivity mediates relationship...

Abstract A gold‐catalyzed intramolecular tandem cyclization of indole‐ynamide affords tetracyclic spirocyclic pyrrolidinoindoline bearing an all‐carbon quaternary stereocentre in a single step; however, when the reaction was carried out presence BF 3 ⋅Et 2 O, corresponding tricyclic pyrrolidinoindoline‐based enones are produced through key 1,5‐hydride shift. The developed chemistry provides diastereoselective and straightforward entry to structurally diverse polycylic pyrrolidinoindolines...

Metal-mediated cyclizations are important transformations in a natural product total synthesis. The Pauson-Khand reaction, particularly powerful for establishing cyclopentenone-containing structures, is distinguished as one of the most attractive annulation processes routinely employed synthesis campaigns. This review covers Co, Rh, and Pd catalyzed reaction summarizes its strategic applications syntheses structurally complex products last five years. Additionally, hetero-Pauson-Khand...

Measuring the chemical composition of individual atmospheric aerosol particles can provide direct evidence their heterogeneous reactions and mixing states in atmosphere. In this study, micro-Raman spectroscopy was used to measure 1200 11 samples collected Beijing air. (NH4)2SO4, NH4NO3, various minerals, carbonaceous species (soot organics), NaNO3 were identified measured according characteristic Raman peaks. These represented main components particles. particles, NH4NO3 (NH4)2SO4 either...

Abstract A novel method for the concise synthesis of cyclohepta[b]indoles in high yields was developed. The involves a visible‐light‐induced, photocatalyzed [2+2]‐cycloaddition/ retro‐Mannich‐type reaction enaminones. Experimental and computational studies suggested that is photoredox process initiated by single‐electron oxidation an enaminone moiety, which undergoes subsequent cyclobutane formation rapidly fragmentation radical‐cation state to form cyclohepta[b]indoles.

Abstract A multifunctional polydopamine/mesoporous silica nanoparticles loaded cryptotanshinone (PDA/MSN@CTS) was synthesized and subjected to investigating its physicochemical properties anti‐gastric cancer (GC) effects. Utilizing network pharmacology molecular docking techniques, CTS identified as our final research target. The structural morphology of PDA/MSN@CTS were examined. Near‐infrared (NIR) laser employed evaluate the photothermal PDA/MSN@CTS, along with pH‐responsive NIR‐triggered...

α9-Containing nicotinic acetylcholine receptors (nAChRs) are key targets for the treatment of neuropathic pain. α-Conotoxin RgIA4 is a peptide antagonist human α9α10 nAChRs with high selectivity. However, structural rearrangement reveals potential liability clinical applications. We herein report our designer RgIA analogues stabilized by methylene thioacetal as nonopioid analgesic agents. demonstrate that replacing disulfide loop I [CysI-CysIII] in skeleton results activity loss, whereas...

The formal total synthesis of (±)-lycojaponicumin C has been accomplished. Key transformations include a Rh-catalyzed [3 + 2] cycloaddition reaction to construct the bicyclic [3.3.0] scaffold bearing two vicinal quaternary carbon centers, stereoselective γ-hydroxyl directed Michael addition introduce vinyl group at bulky position, and late-stage ring-closing metathesis form cyclohexanone ring.

Insulin has been a life-saving drug for millions of people with diabetes. However, several challenges exist which limit therapeutic benefits and reduce patient convenience. One key challenge is the fibrillation propensity, necessitates refrigeration storage. To address this limitation, we chemically synthesized evaluated methylene thioacetal human insulin analogue (SCS-Ins). The SCS-Ins showed enhanced serum stability aggregation resistance while retaining bioactivity compared native insulin.

Here, we report a practical and reliable methodology to direct construction of tri- tetrasubstituted olefins bearing an allylic amine, with the concomitant sterically congested quaternary stereocenter through stereoselective palladium-catalyzed cascade decarboxylation vinyloxazolidinones.

Non-opioid therapeutics for the treatment of neuropathic pain are urgently needed to address ongoing opioid crisis. Peptides from cone snail venoms have served as invaluable molecules target key pain-related receptors but can suffer unfavorable physicochemical properties, which limit their therapeutic potential. In this work, we developed conformationally constrained α-RgIA analogues with high potency, receptor selectivity, and enhanced human serum stability α9α10 nicotinic acetylcholine...

Abstract: The microstructure of palygorskite from Longwang Mountain Xuyu County, Jiangsu Province, was studied by energy dispersive X‐ray analysis (EDX), selected‐area electron diffraction (SAED) and high‐resolution transmission microscopy (HRTEM). average composition the is (Si 7.38 Al 0.62 ) (Al 0.96 Fe 3+ Mg 2.86 □ 0.56 )Ca 0.03 K 0.06 O 20 (OH) 2 (OH 4 , which rich in Mg. Several SAED patterns a single crystal were obtained with different zone axes. polymorphs (monoclinic orthorhombic)...

Abstract We used illite and chlorite crystallinities, index minerals, mineral assemblages, polytype domain size of white mica, electron microprobe analysis (EMPA), b 0 geobarometer geothermometer to quantify the diagenetic metamorphic overprint on Triassic flysch formations in Songpan‐Garzê orogen along profile Zoigê‐Lushan, northwest Sichuan. Two anchizones, two epizones, one zone a transition belt in‐between them are defined basis obtained data. Illite crystallinity correlates strongly...

Abstract Insulin analogs are key to blood glucose management for millions of people with diabetes. Nonetheless, the risk hypoglycemia still exists because this insulin remains bioactive at normal or low conditions. Here, aim is incorporate phenylboronic acids on glargine create a glucose‐responsive designer termed “PBA‐F‐glargine.” It hypothesized that by inserting responsive moiety, increases therapeutic window and reduces insulin‐induced hypoglycemia. Chemical methods used into glargine....

Glucose-responsive insulin represents a promising approach to regulate blood glucose levels. We previously showed that attaching two fluorophenylboronic acid (FPBA) residues the C-terminal B chain of glargine led glucose-dependent solubility. Herein, we demonstrated relocating FPBA from A increased baseline solubility without affecting its potency. Furthermore, increasing number groups

A Cr₈ metallacrown binds halogens X₂ (Cl₂, Br₂ and I₂) without loss of crystallinity; the binding has been studied by X-ray diffraction thermodynamic techniques.

(-)-Anisomelic acid, isolated from

Depression is a common psychiatric disorder with high recurrence rate leading to suicidal thoughts in some cases. Albiflorin monoterpene glycoside that commonly used the treatment of disorders. However, underlying mechanism albiflorin on depression unclear and remains be investigated. To this end, mouse model was established via chronic unpredictable mild stress treatment. Next, effects these mice were evaluated using sucrose preference test, forced swim tail suspension open field test. The...

Cucurbit[7]uril (CB[7]) is a supramolecular binding host for peptides and proteins with N-terminal Phe. However, the low occurrence of such limits broader applications this unique host-guest interaction. Here, we report strategy to expand scope CB[7]-peptide interaction by site-specifically introducing substitutions (e.g. benzyl groups) using reductive alkylation. benzylated have similar affinity CB[7] as native Phe even stronger interactions can be achieved better ligands. We further...

An efficient method for the practical formation of functionalized spirooxindoles, which was accompanied by generating a sterically congested spiroketal system and bearing two quaternary stereocenters via sequential palladium, catalyzed decarboxylative [3 + 2] cycloaddition vinylethylene carbonates (VECs) isatins. Importantly, redox‐neutral catalytic possesses characteristics operational convenience, good functional group tolerance, regioselectivity diastereoselectivity, enables...

Chronic kidney disease (CKD) is a growing public health issue with significant morbidity and mortality rates. Traditional diagnostics, about 70% accuracy, often delay CKD detection, highlighting the need for more efficient methods. Recent studies indicate potential link between auditory health, yet this relationship remains underexplored due to methodological challenges complexity of establishing causality. Our research utilizes data spanning from 2000 2020 National Health Nutrition...