A5083598713- Melanoma and MAPK Pathways
- Skin Protection and Aging
- MicroRNA in disease regulation
- Full-Duplex Wireless Communications
- Computational Drug Discovery Methods
- Cutaneous Melanoma Detection and Management
- Polyomavirus and related diseases
- Mosquito-borne diseases and control
- Genomics, phytochemicals, and oxidative stress
- Antenna Design and Analysis
- Circular RNAs in diseases
- Viral Infections and Vectors
- DNA Repair Mechanisms
- melanin and skin pigmentation
- Pregnancy-related medical research
- Cancer-related molecular mechanisms research
- Endometriosis Research and Treatment
- Genomics and Chromatin Dynamics
- Circadian rhythm and melatonin
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Sirtuins and Resveratrol in Medicine
- RNA modifications and cancer
- Menstrual Health and Disorders
- CRISPR and Genetic Engineering
Structure Fédérative de Recherche en Biologie et Santé de Rennes
2013-2022
Université de Rennes
2010-2022
Centre National de la Recherche Scientifique
2011-2022
Inserm
2021-2022
Université Rennes 2
2021
Institut de génétique et de développement de Rennes
2009-2019
Université Européenne de Bretagne
2015
Centre Hospitalier privé Saint Grégoire
2010-2012
BRAF inhibitors target the BRAF-V600E/K mutated kinase, driver mutation found in 50% of cutaneous melanoma. They give unprecedented anti-tumor responses but acquisition resistance ultimately limits their clinical benefit. The master regulators driving expression resistance-genes remain poorly understood. Here, we demonstrate that Aryl hydrocarbon Receptor (AhR) transcription factor is constitutively activated a subset melanoma cells, promoting dedifferentiation cells and BRAFi-resistance...
Helicobacter pylori (Hp) is a major risk factor for gastric cancer (GC). Hp promotes DNA damage and proteasomal degradation of p53, the guardian genome stability. reduces expression transcription USF1 shown to stabilise p53 in response genotoxic stress. We investigated whether Hp-mediated deregulation impacts p53-response consequently genetic instability. also explored vivo role carcinogenesis.Human epithelial cell lines were infected with Hp7.13, exposed or not DNA-damaging agent...
Human skin is constantly exposed to UV light, the most ubiquitous environmental stressor. Here, we investigated expression and regulation of Nrf1-3, transcription factors crucially involved in protection against oxidative stress human cells vitro, ex vivo, situ. In particular, examined whether α-MSH, a UV-induced peptide, capable modulating Nrf2 Nrf-dependent gene expression. Nrf1, -2, -3 were found be expressed various cutaneous cell types vitro. Surprisingly, UVB irradiation at...
Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer involving cells. Recently, new human polyomavirus was implicated in MCC, being present 80% of the samples analyzed. In virus-positive (MCPyV) clonally integrated into patients DNA, and carries mutations its large T antigen, leading to truncated protein. non-symptomatic tissue MCPyV can reside at very low levels. MCC also associated with older age, immunosuppression sun exposure. However, link solar exposure remains unknown, as...
Genomic instability is a major hallmark of cancer. To maintain genomic integrity, cells are equipped with dedicated sensors to monitor DNA repair or force damaged into death programs. The tumor suppressor p53 central in this process. Here, we report that the ubiquitous transcription factor Upstream Stimulatory 1 (USF1) coordinates function making proper cell fate decisions. USF1 stabilizes protein and promotes transient cycle arrest, presence damage. Thus, proliferation maintained...
Abstract Background Mutations of BRAF, NRAS and c‐KIT oncogenes are preferentially described in certain histological subtypes melanoma linked to specific histopathological features. BRAF‐, MEK‐ KIT‐inhibitors led improvement overall survival patients harbouring mutated metastatic melanoma. Objectives To assess the prevalence types NRAS, MITF mutations cutaneous mucous correlate mutation status with clinicopathological features outcome. Methods Clinicopathological 108 samples 98 consecutive...
An important function of all organisms is to ensure that their genetic material remains intact and unaltered through generations. This an extremely challenging task since the cell's DNA constantly under assault by endogenous environmental agents. To protect against this, cells have evolved effective mechanisms recognize damage, signal its presence, mediate repair. While these responses are expected be highly regulated because they critical avoid human diseases, very little known about...
Angiotensin-converting enzyme 2 (ACE2) is the receptor of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) causing disease 2019 (COVID-19). Transmembrane serine protease (TMPRSS2) a coreceptor. Abnormal hepatic function in COVID-19 suggests specific or bystander liver disease. Because cancer cells express ACE2 viral receptor, they are widely used as models SARS-CoV-2 infection vitro. Therefore, purpose this study was to analyze and TMPRSS2 expression localization human cancers...
Solar radiation is one of the most common threats to skin, with exposure eliciting a specific protective cellular response. To decrypt underlying mechanism, we used whole genome microarrays (Agilent 44K) study epidermis gene expression in vivo skin exposed simulated solar (SSR). We procured samples from healthy Caucasian patients, phototypes II or III, and two different SSR doses (2 4 J/cm(2)), lower which corresponded minimal erythemal dose. Analyses were carried out five hours after...
Usutu virus (USUV) and West Nile (WNV) are phylogenetically close emerging arboviruses constitute a global public health threat. Since USUV WNV transmitted by mosquitoes, the first immune cells they encounter skin-resident dendritic cells, most peripheral outpost of defense. This unique network is composed Langerhans (LCs) dermal DCs, which reside in epidermis dermis, respectively. Using human skin explants, we show that while both viruses can replicate keratinocytes, also infect resident...
We previously demonstrated that mast cells expressing HLA-G are associated with regions of hepatitis C virus-induced liver fibrosis. Here, we aimed to determine whether expression in is specific viral etiology, the liver, or general process enumerated HLA-G+ and by immunohistochemistry (i) blocks from 41 cases alcoholic cirrhosis, (ii) 10 idiopathic pulmonary fibrosis (IPF), (iii) renal The nature was specified multiplex immunofluorescence using software. More than half all were fibrotic...
Human skin is constantly exposed to UV light, the most ubiquitous environmental stressor. Here, we investigated expression and regulation of Nrf1-3, transcription factors crucially involved in protection against oxidative stress, human cells vitro, ex vivo situ. In particular, examined whether α-MSH, a UV-induced peptide, capable modulating Nrf1/2 Nrf-dependent gene expression. Both Nrf1 2 were found be expressed various cutaneous cell types vitro. Surprisingly, UVB irradiation at...
Abstract RNAs competition to bind miRNA has been proposed influence biological systems whether these are implicated in diseases onset is unclear. Here, we report that TYRP1 mRNA, addition encoding tyrosinase-related protein 1 (TYRP1), indirectly governs cell proliferation by sequestering miR-16 on non-canonical response elements (MREs). Consequently, sequestered no longer able repress its mRNA targets such as RAB17, which show involved melanoma and invasion. Restoration of tumor suppressor...
e19037 Background: The recent understanding of melanomas’ molecular pathways improved their classification and clinical strategies. Initial studies showed that B-Raf/N-Ras mutations (respectively V600E Q61) are the most frequent alterations being present in 70 to 80% melanomas, characterizing non Chronic Sun-induced Damage skins (CSD). These include Superficial Spreading Melanomas (SSM) Nodular (NM). Other c-Kit at low rate (20-40%) Acro-Lentiginous (ALM), Mucous (MM) melanomas arising on...