A5028324407- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- Cardiomyopathy and Myosin Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- CRISPR and Genetic Engineering
- Electrospun Nanofibers in Biomedical Applications
- Cardiac electrophysiology and arrhythmias
- Cardiac Fibrosis and Remodeling
- Cellular Mechanics and Interactions
- Cardiovascular Function and Risk Factors
- Sparse and Compressive Sensing Techniques
- HIV-related health complications and treatments
- Advanced MRI Techniques and Applications
- Quantum and electron transport phenomena
- Medical Image Segmentation Techniques
- Nuclear Issues and Defense
- Medical Imaging Techniques and Applications
- Direction-of-Arrival Estimation Techniques
- Atomic and Subatomic Physics Research
- Heart Failure Treatment and Management
- International Maritime Law Issues
- Metal complexes synthesis and properties
- Chemical Reactions and Isotopes
- Cancer Treatment and Pharmacology
Northwestern University
2020-2024
University of Southern California
2017-2020
Living Systems (United States)
2017-2020
Southern California University for Professional Studies
2017
Los Angeles City College
2017
Viterbo University
2017
Universidade de Brasília
2012
Genome-wide association studies and candidate gene have identified more than 180 genetic variants statistically associated with anthracycline-induced cardiotoxicity (AIC). However, the lack of functional validation has hindered clinical translation these findings. The aim this study was to functionally validate all genes AIC using human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs). Through a systemic literature search, 80 containing significantly were identified....
Background: Multiple pharmacogenomic studies have identified the synonymous genomic variant rs7853758 (G > A, L461L) and intronic rs885004 in SLC28A3 (solute carrier family 28 member 3) as statistically associated with a lower incidence of anthracycline-induced cardiotoxicity. However, true causal variant(s), cardioprotective mechanism this locus, role other solute (SLC) transporters cardiotoxicity, suitability SLC targets for drugs has not been investigated. Methods: Six well-phenotyped,...
Mitochondria in cardiac myocytes are critical for generating ATP to meet the high metabolic demands associated with sarcomere shortening. Distinct remodeling of mitochondrial structure and function occur both developmental pathological settings. However, factors that underlie these changes poorly understood. Because tissue architecture extracellular matrix (ECM) elasticity also hallmarks ventricular development disease, we hypothesize environmental regulate myocytes. To test this, developed...
The nutritional requirements for human induced pluripotent stem cell (hiPSC) growth have not been extensively studied. Here, building on our prior work that established the suitable non-basal medium components hiPSC growth, we develop a simplified basal consisting of just 39 components, demonstrating many ingredients DMEM/F12 are either essential or at suboptimal concentrations. This new along with supplement, which call BMEM, enhances rate hiPSCs over DMEM/F12-based media, supports...
By engineering tunable myocardial microtissues, we established that matrix elasticity regulates contractility more strongly than ligand and fibroblast : myocyte ratio.
The reconstruction of multi-dimensional magnetic resonsance imaging (MRI) data can be a computationally demanding task. Signal-to-noise ratio is also concern, specially in high-resolution imaging. Data compression may useful not only for reducing complexity and memory requirements, but noise, as it capable eliminating spurious components. This work proposes the use SVD-based low-rank approximation denoising MRI data. Akaike information criterion used to estimate appropriate model order....
The protocol provided here describes methodologies for making a highly cost-effective, chemically defined medium culturing hiPSCs we call B8 medium. typical cost of is US$10 per liter, which with modifications included more affordable than standard media. We provide simple protocols supplement aliquots, the basal media DMEM/F12, Matrigel-coated plates, thawing, passaging, culturing, and cryopreserving hiPSCs. show differentiation results comprehensive troubleshooting guide. For complete...
Abstract Disruptions to cardiac tissue microstructure are common in diseased or injured myocardium and known substrates for arrhythmias. However, we have a relatively coarse understanding of the relationships between myocardial microstructure, propagation velocity calcium cycling, due largely limitations conventional experimental tools. To address this, used microcontact printing engineer strands with eight different widths, quantified several structural functional parameters established...
Abstract We have previously developed a cost‐effective chemically defined medium formula for weekend‐free culture of human induced pluripotent stem cells (hiPSCs), costing ∼3% the price commercial medium. This medium, which we termed B8, is specifically optimized robust and fast growth hiPSCs change regimen. demonstrated that this suitable reprogramming somatic into differentiation variety lineages. Here, provide protocol simple generation most variant along with making Matrigel‐coated...
La reconstruccion de datos resonancia magnetica (RM) puede ser una tarea computacionalmente ardua. razon senal-ruido tambien presentar complicaciones, especialmente en imagenes alta resolucion. En este sentido, la compresion util no solo para reducir complejidad y los requerimientos memoria, sino el ruido, hasta inclusive permitir eliminar componentes espurios. El presente trabajo propone uso un sistema basado descomposicion por valores singulares bajo orden reduccion ruido RM. criterio...
Abstract Heart failure with preserved ejection fraction (HFpEF) is commonly found in persons living HIV (PLWH) even when antiretroviral therapy (ART) suppresses viremia. However, studying this condition has been challenging because an appropriate animal model not available. In paper, we studied calcium transient human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) culture to simulate the cardiomyocyte relaxation defect noted of PLWH and HFpEF assess whether various drugs...
Heart failure with preserved ejection fraction (HFpEF) is commonly found in persons living HIV (PLWH) even when antiretroviral therapy suppresses viremia. However, studying this condition has been challenging because an appropriate animal model not available. In article, we studied calcium transient human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) culture to simulate the cardiomyocyte relaxation defect noted PLWH and HFpEF assess whether various drugs have effect. We...
Heart failure with preserved ejection fraction (HFpEF) is commonly found in persons living HIV (PLWH) even when antiretroviral therapy (ART) suppresses viremia. However, studying this condition has been challenging because an appropriate animal model not available. In paper, we studied calcium transient human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) culture to simulate the cardiomyocyte relaxation defect noted of PLWH and HFpEF assess whether various drugs have...
Heart failure with preserved ejection fraction (HFpEF) is commonly found in persons living HIV (PLWH) even when antiretroviral therapy suppresses viremia. However, studying this condition has been challenging because an appropriate animal model not available. In article, we studied calcium transient human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) culture to simulate the cardiomyocyte relaxation defect noted PLWH and HFpEF assess whether various drugs have effect. We...
Models and numerical simulations are used to understand concepts of electronic circuits as well evaluate their performance without the actual need build them. Today, they mostly implemented by softwares that rely on solutions analytic models, which usually require a great amount computational resources. In this paper, we propose an alternative particle dynamical system model circuits. Its main features very simple evolution rule, resembles principles classical electrodynamics, purely...
This paper demonstrates parallel imaging acceleration of spiral Fourier velocity encoded MRI using the iterative self-consistent reconstruction (SPIRiT) technique. Magnitude images and time-velocity distributions obtained with image domain SPIRiT sum-of-squares are compared, for 2-fold 4-fold undersampling. We show that is able to reduce spatial aliasing from undersampled distributions, good results undersampling, moderately
The present article addresses the regional mechanisms to control proliferation of nuclear weapons, more specifically proposal create a Nuclear Weapon Free Zone (NWFZ) in Middle East.First, draws background on non-proliferation regimen and successful proposals creation NWFZ other regions world.After, revises recent history East, from State Israel, emphasizing episodes related violation nonproliferation disarmament initiatives.This states that East depends collaboration powers, sense not...