A5043561751- Congenital heart defects research
- Congenital Heart Disease Studies
- Tissue Engineering and Regenerative Medicine
- Cryospheric studies and observations
- Arctic and Antarctic ice dynamics
- Coronary Artery Anomalies
- Chemotherapy-induced cardiotoxicity and mitigation
- Pluripotent Stem Cells Research
- Climate change and permafrost
- Childhood Cancer Survivors' Quality of Life
- graph theory and CDMA systems
- Nutrition and Health in Aging
- Genetic factors in colorectal cancer
- Genetic and Kidney Cyst Diseases
- Advanced Proteomics Techniques and Applications
- Phagocytosis and Immune Regulation
- Machine Learning in Bioinformatics
- Matrix Theory and Algorithms
- PARP inhibition in cancer therapy
- Colorectal Cancer Treatments and Studies
- Renal and related cancers
- Genomic variations and chromosomal abnormalities
- Autophagy in Disease and Therapy
- Frailty in Older Adults
- RNA and protein synthesis mechanisms
Northwestern University
2017-2024
Beijing Institute of Big Data Research
2023-2024
University of Chinese Academy of Sciences
2023-2024
Aerospace Information Research Institute
2023-2024
Chinese Academy of Sciences
2023-2024
Shanghai University of Medicine and Health Sciences
2021
Yale Cancer Center
2015
Yale University
2014-2015
Erasmus MC
2012
SUNY Upstate Medical University
2012
Genome-wide association studies and candidate gene have identified more than 180 genetic variants statistically associated with anthracycline-induced cardiotoxicity (AIC). However, the lack of functional validation has hindered clinical translation these findings. The aim this study was to functionally validate all genes AIC using human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs). Through a systemic literature search, 80 containing significantly were identified....
Congenital heart malformations are a major cause of morbidity and mortality, especially in young children. Failure to establish normal left-right (L-R) asymmetry often results cardiovascular other laterality defects visceral organs.To identify genetic mutations causing cardiac defects.We performed genome-wide linkage analysis patients with from consanguineous family. The had combinations that included dextrocardia, transposition great arteries, double-outlet right ventricle, atrioventricular...
Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After ischemia and reperfusion, acute inhibition with blocking antibodies enhanced dead myocyte clearance phagocytes also improved resolution inflammation, reduced infarct size, preserved contractile function. Early targeting in myocardium reperfusion may be new...
Coarctation of the aorta (CoA) and hypoplastic left heart syndrome (HLHS) have been reported in rare individuals with large terminal deletions chromosome 15q26. However, no single gene important for ventricular outflow tract (LVOT) development has identified this region. Using array-comparative genomic hybridization, we two half-siblings CoA a 2.2 Mb deletion on 15q26.2, inherited from their mother, who was mosaic deletion. This interval contains an evolutionary conserved, protein-coding...
As heart failure due to myocardial infarction remains a leading cause of morbidity worldwide, cell-based cardiac regenerative therapy using progenitor cells (CPCs) could provide potential treatment for the repair injured myocardium. adult CPCs may have limitations regarding tissue accessibility and proliferative ability, derived from embryonic stem (ESCs) serve as an unlimited source with high ability. one that can be cells, Isl1 expressing (Isl1-CPCs) valuable their differentiation...
Mutations in ZIC3 cause human X-linked heterotaxy and isolated cardiovascular malformations. A mouse model with targeted deletion of Zic3 demonstrates an early role for gastrulation, CNS, cardiac left–right axial development. The observation multiple malformations Zic3null mice the relatively broad expression pattern suggest its important roles developmental processes. Here, we report that is primarily required epiblast derivatives to affect patterning necessary proper transcriptional...
The detection of mutations in KRAS, NRAS, BRAF, and PIK3CA has become essential managing the treatment metastatic colorectal cancer (CRC) with approval new targeted therapies. We developed novel multiplex drop-off digital PCR (MDO-dPCR) assays by combining amplitude-/ratio-based multiplexing drop-off/double strategies that allow for at least 69 most frequent hotspot all four genes only three reactions. analytical performance was assessed using synthetic oligonucleotides, which were further...
Establishing codon usage biases are crucial for understanding the etiology of central nervous system neurodegenerative diseases (CNSNDD) especially Alzheimers disease (AD) as well genetic factors. G and C ending codons strongly biased in coding sequences these proteins a result genomic GC composition constraints. On other hand, that identified translationally optimal major trend all end or G, suggesting translational selection should also be taken into consideration additional to...
Since the beginning of 20th century, surface air temperature in Arctic has increased more than three times faster global average. River ice is an important component terrestrial cryosphere, which very sensitive to temperature. The Yenisei originates from Sayan Mountains Mongolia and largest watersheds drained by Ocean, covers latitudes 46°N 73°N. changes river for provides reflect response great rivers high Northern Hemisphere climate change. In this study, daily coverage...
The existence of a 6est approximation to the pairwise comparison matrix from set consistent Aatrioes is proved.At same time, we can also prove that there are many best approximations.Then by diffeomorphism, transform primary nonlinear into linear one.Hence get an approximate method abtain approximation.Finally, give simple example.