A5017290810- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Complement system in diseases
- Chronic Myeloid Leukemia Treatments
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Renin-Angiotensin System Studies
- Inflammatory Biomarkers in Disease Prognosis
- Eosinophilic Disorders and Syndromes
- Asthma and respiratory diseases
- Thyroid Cancer Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Hemoglobinopathies and Related Disorders
- Thyroid and Parathyroid Surgery
- Occupational and environmental lung diseases
- Erythrocyte Function and Pathophysiology
- Blood disorders and treatments
- Acute Lymphoblastic Leukemia research
- Pleural and Pulmonary Diseases
- Renal Diseases and Glomerulopathies
- Hormonal Regulation and Hypertension
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Acute Kidney Injury Research
- Histone Deacetylase Inhibitors Research
Hospital Universitario Son Espases
2015-2024
Health Research Institute of the Balearic Islands
2019-2024
Hospital de Basurto
2021
NED University of Engineering and Technology
2021
Onconova Therapeutics (United States)
2019
Universidad de Murcia
2001-2015
Military Institute of Engineering
2011
Medical College of Wisconsin
2005
The xCELLigence system is a new technological approach that allows the real-time cell analysis of adherent tumor cells. To date, has not been able to monitor growth or cytotoxicity nonadherent cells derived from hematological malignancies. basis its technology relies on use culture plates with gold microelectrodes located in their base. We have adapted methodology described by others xCELLigence, based pre-coating surface specific substrates, some which are known facilitate adhesion...
Angiotensin II is known to stimulate NADPH oxidase-dependent superoxide (O 2 − ) generation, which may contribute the acute renal vasoconstrictor and antinatriuretic actions of this peptide. To evaluate hypothesis, effects a dismutase mimetic (tempol) or inhibitor (apocynin) on angiotensin were studied. Renal cortical nitric oxide (NO) was measured electrochemically in vivo. Tempol increased sodium excretion NO levels. Apocynin raised blood flow, glomerular filtration rate, excretion, These...
Females suffer a less severe ischemic acute renal failure than males, apparently because of higher nitric oxide (NO) bioavailability and/or lower levels oxidative stress. Because the injury is associated with outer medullary (OM) endothelial dysfunction, present study evaluated sex differences in OM changes NO and peroxynitrite (by differential pulse voltammetry amperometry, respectively) during 45 min ischemia 60 reperfusion anesthetized Sprague-Dawley rats. Endothelial synthase (eNOS)...
The present study evaluated whether the impairment in autoregulation of renal blood flow (RBF) fawn-hooded Hypertensive (FHH) rat colocalizes with Rf-1 region on chromosome 1 that has been previously linked to development proteinuria this strain. Autoregulation RBF was measured FHH and a consomic strain (FHH.1 BN ) which from Brown-Norway (BN) introgressed into genetic background. indexes (AI) averaged 0.80 ± 0.08 0.19 0.05 FHH.1 rats. We next performed linkage analysis for 85 F2 rats...
Rationale: Blood eosinophil count predicts response to inhaled corticosteroids and specific biologic therapies in selected patients with asthma. Despite this important role, fundamental aspects of behavior asthma have not been studied. Objectives: To investigate the blood eosinophils a population, comparing their distribution general population studying intraindividual variability over time relation hospital episodes (emergency department visits hospitalizations) clinical practice. Methods:...
The present study examined whether transfer of overlapping regions chromosome 5 that include (4A + ) or exclude the cytochrome P-450 (CYP) 4A genes from Lewis rat alters renal production 20-hydroxyeicosatetraenoic acid (20-HETE) and/or development hypertension in congenic strains Dahl salt-sensitive (S) rats. expression CYP4A protein and 20-HETE outer medulla was greater strain than levels seen S rats control region. Mean arterial pressure (MAP) rose 122 ± 2 to 190 7 mmHg 119 123 189 187 3...
The present study evaluated whether inhibition of guanylyl cyclase (GC) with 1H-(1,2,4)oxadiazolo[4,3-a]quinoxaline-1-one (ODQ) and methylene blue (MB) or the renal metabolism arachidonic acid by cytochrome P-450 (CYP450) enzymes 1-aminobenzotriazole (ABT) N-hydroxy- N′-(4 butyl-2-methyl phenyl)formamidine (HET0016) alters tubular vascular effects a nitric oxide (NO) donor in vivo. Intrarenal infusion ODQ MB at dose 170 nmol · kg −1 min lowered blood flow (RBF) 30 15%, respectively;...
Thrombotic microangiopathy (TMA) is an important complication associated with several diseases that are rare and life-threatening. TMA common to thrombotic thrombocytopenic purpura (TTP) hemolytic uremic syndrome (HUS). TTP defined by a severe deficiency of ADAMTS13, early treatment good prognosis. The diagnosis HUS can be difficult due the potential multiple etiologies, best option in most cases not well-established yet. implementation multidisciplinary team (MDT) could decrease time for...
B Acute Lymphoblastic leukemia (B-ALL) with Philadelphia chromosome (Ph′) is a neoplasm of lymphoblast committed to the cell lineage. The clinical presentation B-ALL Ph′+ similar B-ALL, but more common in adults than children. e1a3 rare variant produced by fusion BCR exon 1 ABL 3. presence this translocation has been associated good disease outcome for chronic myeloid very small series only 5 cases; there no such evidence B-ALL. We report two new cases Ph+ transcript. and e1a2 (p190)...
Bone marrow infiltration by alveolar rhabdomyosarcoma is uncommon, some cases can mimicry acute leukemia at presentation and mislead the diagnosis. The integration of diagnostics tests techniques in uncommon malignancies important to suspect reach diagnosis avoid delay on treatment. We report a case bone associated with hemophagocytosis cell cannibalism, mimicking presentation.
Introduction NETosis, the mechanism by which neutrophils release extracellular traps (NETs), is closely related to inflammation. During allogeneic hematopoietic stem cell transplantation (allo-HSCT), different stimuli can induce NETs formation. Inflammation and endothelial injury have been associated with acute graft-versus-host disease (aGVHD) complications after allo-HSCT. We focus on study of NETosis its relation cytokines, hematological biochemical parameters clinical outcomes before,...
Thrombotic microangiopathy (TMA), characterized by microangiopathic hemolytic anemia, thrombocytopenia, and multisystem organ dysfunction, is a life-threatening disease. Patients with TMA who do not exhibit severe ADAMTS-13 deficiency (defined as disintegrin-like metalloprotease thrombospondin type 1 motif no. 13 activity ≥10%: TMA-13n) continue to experience elevated mortality rates. This study explores the prognostic indicators for augmented risk or necessitating chronic renal replacement...
Introduction: Cytogenetic studies on stingless bees have significantly contributed to our understanding of karyotypic evolution and the composition euchromatin heterochromatin regions, including repetitive sequences. Methods: In this study, we performed classical cytogenetics, chromosomal banding, mapping some sequences in two bee species, Frieseomelitta trichocerata Plebeia poecilochroa. Results: The species exhibit typical diploid chromosome number each genera, 2n=30 for 2n=34 Plebeia....