A5067279493- Essential Oils and Antimicrobial Activity
- Graphene and Nanomaterials Applications
- Diverse academic and cultural studies
- Antifungal resistance and susceptibility
- Gut microbiota and health
- Plant Pathogens and Fungal Diseases
- Gastrointestinal motility and disorders
- Phytochemistry and Biological Activities
- Probiotics and Fermented Foods
- Bone health and treatments
- Nanocomposite Films for Food Packaging
- Olfactory and Sensory Function Studies
- Biomarkers in Disease Mechanisms
- Insect and Pesticide Research
- Bee Products Chemical Analysis
- Dermatology and Skin Diseases
- Antimicrobial Peptides and Activities
- Macrophage Migration Inhibitory Factor
- Complementary and Alternative Medicine Studies
- Conservation Techniques and Studies
- Estrogen and related hormone effects
- Thyroid Cancer Diagnosis and Treatment
- Moringa oleifera research and applications
- Carbon and Quantum Dots Applications
- Natural product bioactivities and synthesis
Università Cattolica del Sacro Cuore
2018-2025
University of Colorado Anschutz Medical Campus
2025
Agostino Gemelli University Polyclinic
2020-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
University of Bologna
2018-2021
Istituto Superiore di Sanità
2015-2017
Ospedale San Filippo Neri
2015
Sapienza University of Rome
2004-2012
Policlinico Umberto I
2007
University of Siena
2006
Adaptation to hypoxia and consequent pro-inflammatory gene expression of prostate breast carcinomas have been implicated in the progression toward cancer malignant phenotype. Only partial data are available for human tumor glioblastoma multiforme (GBM). The aim our study was analyze hypoxic microenvironment GBMs demonstrate that a stem/progenitor cell line derived from (GBM-SCs), activates coordinated inflammatory response, evidencing an invasive migratory phenotype.From each 10 solid...
Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for serious hospital infections worldwide and represents a global public health problem. Curcumin, the major constituent of turmeric, effective against MRSA but only at cytotoxic concentrations or in combination with antibiotics. The issue curcumin-based therapies poor solubility this hydrophobic compound cytotoxicity high doses. In paper, we describe efficacy composite nanoparticle made curcumin (CU) graphene oxide (GO),...
Abstract Studies so far conducted on irritable bowel syndrome (IBS) have been focused mainly the role of gut bacterial dysbiosis in modulating intestinal permeability, inflammation, and motility, with consequences quality life. Limited evidences showed a potential involvement fungal communities. Here, microbiota cohort IBS patients characterized compared that healthy subjects (HS). The microbial community structure differed significantly to HS. In particular, we observed an enrichment taxa...
Among the top five human infections requiring medical treatment is dermatitis. Treatment of bacterial and fungal skin usually based on antibiotic therapy, which often ineffective due to involvement antibiotic-resistant microbial strains. The aim this study was compare antimicrobial activity essential oils (EOs) hydrolates (Hys) extracted from six aromatic plants grown in Italy (Lavandula angustifolia, Lavandula intermedia, Origanum hirtum, Satureja montana, Monarda didyma, fistulosa) towards...
Monarda spp. are promising Lamiaceae due to essential oil (EO) composition and antimicrobial activity. To investigate these properties, didyma M. fistulosa were grown for two years in Italian sites EO extraction (distillation), analysis (GC GC/MS), activity (microplate diffusion broth method). yield greatly increased from first second year of cultivation (0.27 0.51% 2013 2014, respectively), showing minor differences between fistulosa. Conversely, significantly varied the species years. Of...
Four cultivars (cv) of Lavandula x intermedia ('Abrialis', 'Alba', 'Rinaldi Ceroni' (R.C.) and 'Sumiens') were cultivated in Italy their essential oils (EOs) distilled from Alfalfa Mosaic Virus-free plants. These EOs one L. angustifolia Miller chemically characterised by GC-MS GC-FID. Antimicrobial activity was evaluated against Listeria monocytogenes (24 strains) Salmonella enterica (10 food strains). Minimal inhibitory concentrations (MIC) ≥ 10.0 μL/mL inhibited (cv 'R.C.' the most...
Candida auris represents an emerging pathogen that results in nosocomial infections and is considered a serious global health problem. The aim of this work was to evaluate the vitro antifungal efficacy Cinnamomum cassia essential oil (CC-EO) pure or formulated polycaprolactone (PCL) nanoparticles against ten clinical strains C. auris.nanoparticles PCL were produced using CC-EO (nano-CC-EO) cinnamaldehyde (CIN) through nanoprecipitation method. chemical profile both nano-CC-EO evaluated SPME...
Candida parapsilosis is the major non-C. albicans species involved in colonization of central venous catheters, causing bloodstream infections. Biofilm formation on medical devices considered one main causes healthcare-associated infections and represents a global public health problem. In this context, development new nanomaterials that exhibit anti-adhesive anti-biofilm properties for coating crucial. work, we aimed to characterize antimicrobial activity two different coated-surfaces,...
Background. The 2015 Nobel Prize in Medicine, awarded for the discovery of artemisinin Artemisia annua, reignited interest aromatic plants, including absinthium L. This article delves into historical, ethnopharmacological and medicinal significance A. absinthium, examining its bitter taste noted since ancient Greek times association with properties throughout history. Despite being banned 20th century due to perceived health risks; recent research has led reconsideration absinthium’s...
Background/Objectives: In recent years, antimicrobial resistance has become a major threat to global health, and scientific research aiming identify new therapeutic resources is priority. Essential oils (EOs), obtained from spices belonging the culinary tradition, like Carum carvi essential oil (CC-EO), are of great interest for their activity, but methods used evaluate efficacy need be standardized. The aims this work were following: (i) best microbiological in vitro test; (ii) surfactant;...
The aim of the study was to test 1) whether chronic and stable coronary artery disease (CAD) could downregulate epicardial fat adrenomedullin synthesis secretion, decrease intracoronary plasma levels, 2) levels be related adipose tissue gene protein expression in subjects with CAD. We examined 12 patients CAD who required bypass graft (CABG) 10 non-CAD underwent cardiac surgery for valve replacement. Plasma were measured peripheral vein circulation, left (LCA) sinus (CS) during angiography....
The role of tumor cells in synthesizing pro‐inflammatory molecules is still controversial. Here we report that hypoxic treatment the MCF‐7 human mammary adenocarcinoma cell line induced activation hypoxia‐inducible factor 1α (HIF‐1α) and nuclear factor‐kappa B (NF‐κB). Importantly, hypoxia regulated expression alarmin receptors such as receptor for advanced glycation end products (RAGE) purinoreceptor (P2X7R), up‐regulated inflammatory response (IR) genes inducible enzymes nitric oxide...
The expression pattern of estrogen receptor (ER) isoforms in normal and tumor thyroid tissues is still controversial poor defined, therefore, a more detailed study the distribution these molecules needed. Most discrepancies might be due to methods utilized. We studied ER human papillary carcinoma (PTC), fine-needle aspiration biopsy-derived specimens, cells, using accurate techniques, such as laser-capture microdissection, real-time quantitative PCR, Western blot. Laser-capture...
The essential oils (EOs) of Origanum compactum and Satureja montana chemotyped (CT) at carvacrol, two Thymus vulgaris CT thujanol thymol, Hydrolates (Hys) S. Citrus aurantium var. amara were chosen for studying their bactericidal efficacy against few phytobacterial pathogens. Minimal Inhibitory Concentration (MIC) Bactericidal (MBC) found by microdilution assay. O. (MBC 0.06% v/v), T. thymol Hy C. 6.25% v/v) resulted in being the most effective Erwinia amylovora; thus, they used as starting...
Candida auris is a multidrug-resistant fungus known to be global public health problem. The skin-based transmission, together with the marked resistance drugs, resulted in its rapid spread all continents. aim of this study was identify an essential oil (EO) active fight against C. auris. A total 15 EOs were tested 10 clinical strains Cinnamomum zeylanicum EO (CZ-EO) most effective (MIC90 and MFC90 equal 0.06% vol/vol). Three fractions obtained from CZ-EO, cinnamaldehyde (CIN), major chemical...
Abstract BACKGROUND Recent studies have underlined the role of tumor cells in endogenous synthesis pro‐inflammatory molecules. We tested whether malignant progression prostate cancer was associated with activation a phenotype typical innate immune system. METHODS The expression set molecules involved tissue inflammation and repair measured by real‐time PCR Western blot analysis samples absence or slight presence detectable leukocyte infiltrate. Whole non‐tumor were analyzed addition to...
Abstract Here, we investigated the possible linkages among geophagy, soil characteristics, and gut mycobiome of indri ( Indri ), an endangered lemur species able to survive only in wild conditions. The eaten by resulted enriched secondary oxide-hydroxides clays, together with a high concentration specific essential micronutrients. This could partially explain role detoxification as nutrient supply. Besides, found that subject geophagy indris’ faeces shared about 8.9% fungal OTUs. Also,...
In this work, Arthrospira platensis grown in Tuscany, Italy, was investigated using different analytical approaches to characterize its volatile and non-volatile chemical composition. The results showed the presence of a high number organic compounds (VOCs) such as hydrocarbons, furans, sulfides, alkanes, aldehydes, alcohols, ketones, esters belonging other classes fatty acids, alcohols sugars. Furthermore, proximal composition analysis also performed determine protein, fat, carbohydrate ash...
Essential oils (EOs) are peculiar phytocomplexes in the already widely varied world of natural bioactive substances [...]
The increasing resistance of fungi to antibiotics is a severe challenge in public health, and newly effective drugs are required. Promising potential medications lipopeptides, linear antimicrobial peptides (AMPs) conjugated lipid tail, usually at the N-terminus. In this paper, we investigated vitro vivo antifungal activity three short myristoylated non-myristoylated derived from mutant AMP Chionodracine. We determined their interaction with anionic zwitterionic membrane-mimicking vesicles...
Successful pregnancy involves a series of events, most them mediated by hormones and cytokines. Estrogens, besides being important for placental growth embryo development, have marked effect on the immune system exerting either pro- or anti-inflammatory properties. Numerous studies suggest that estrogens directly affect cellular function, including cytokine production. Macrophage migration inhibitory factor (MIF) is proinflammatory involved in pregnancy, particularly during earlier stages...