A5046900327- Olfactory and Sensory Function Studies
- Neurobiology and Insect Physiology Research
- Biochemical Analysis and Sensing Techniques
- Turtle Biology and Conservation
- Mosquito-borne diseases and control
- Malaria Research and Control
- Vector-borne infectious diseases
- Parasitic Infections and Diagnostics
- Marine animal studies overview
- Organ Transplantation Techniques and Outcomes
- Parasite Biology and Host Interactions
- Livestock and Poultry Management
- Organ Donation and Transplantation
- Genetic and phenotypic traits in livestock
- Liver Disease and Transplantation
- Animal Nutrition and Physiology
- Physiological and biochemical adaptations
- Trypanosoma species research and implications
- Viral Infectious Diseases and Gene Expression in Insects
- Antimicrobial Peptides and Activities
- Horticultural and Viticultural Research
- Circadian rhythm and melatonin
- Research on Leishmaniasis Studies
- Ion Channels and Receptors
- Helminth infection and control
Obihiro University of Agriculture and Veterinary Medicine
2015-2024
University of Veterinary Medicine
2016-2017
National Institute of Advanced Industrial Science and Technology
2014
Tokyo Metropolitan University
2013
Gifu University
2011-2012
Iwate University
2010-2012
Tohoku University
2012
Jichi Medical University
2003-2007
The midgut environment of anopheline mosquitoes plays an important role in the development malaria parasite. Using genetic manipulation to change mosquito may inhibit parasite, thus blocking transmission. Here we generate transgenic Anopheles stephensi that express C-type lectin CEL-III from sea cucumber, Cucumaria echinata, a midgut-specific manner. has strong and rapid hemolytic activity toward human rat erythrocytes presence serum. Importantly, binds ookinetes, leading inhibition ookinete...
Due to drug resistance, commonly used anti- Babesia drugs have limited efficacy against babesiosis and inflict severe side effects. Tafenoquine (TAF) was approved by the U.S.
Abstract The vomeronasal organ ( VNO ) is a peripheral receptor structure that involved in reproductive behavior and part of the system. Male bears exhibit flehmen regarded as uptake pheromones into to detect estrus females. However, morphological histological features have not been comprehensively studied. present study investigated properties degree development brown bear by histological, histochemical ultrastructural methods. was located at same position many other mammals, it opened...
Abstract In contrast to the main olfactory system that detects volatile chemicals in nasal air, vomeronasal can detect nonvolatile as well volatiles. system, are perceived by organ (VNO) projecting axons accessory bulb (AOB). Beavers ( Castor spp.) semiaquatic mammals have developed chemical communication. It is possible beaver's anal gland secretions, and insoluble substances, may work a messenger water beavers floating on surface via VNO. The present study aimed clarify specificities of...
In the present study, we examined contributions of macrophages to outcome infection with Babesia microti, etiological agent human and rodent babesiosis, in BALB/c mice. Mice were treated clodronate liposome at different times during course B. microti order deplete macrophages. Notably, a depletion host early acute phases caused significant elevation parasitemia associated remarkable mortality The resolving latent resulted an immediate temporal exacerbation coupled Reconstituting...
Glycoconjugates in the olfactory system play critical roles neuronal formation, and α1-2 fucose (α1-2Fuc) glycan mediates neurite outgrowth synaptic plasticity. Histochemical findings of α1-2Fuc mouse detected using Ulex europaeus agglutinin-I (UEA-I) vary. This study histochemically assessed main vomeronasal pathways male female ICR C57BL/6J mice aged 3-4 months UEA-I. reacted with most receptor cells arranged mainly at basal region epithelium. The nerve layer glomerular bulb were speckled...
Abstract Most terrestrial mammals have a vomeronasal system to detect specific chemicals. The peripheral organ of this is (VNO) opening the incisive duct, and its primary integrative center an accessory olfactory bulb (AOB). VNO in seals thought be degenerated like whales manatees, unlike otariids, because absence AOB. However, olfaction plays pivotal roles seals, thus we conducted detailed morphological evaluation three harbor ( Phoca vitulina ). lumen was not found, duct did open into oral...
A robust molecular marker is needed for discrimination of amphistome species, because identification based on morphology alone requires specialized knowledge and techniques. In this study, we performed morphological characterization Explanatum explanatum, a species that causes severe liver damage in definitive host species. Fifty-five adult amphistomes were collected from cattle water buffaloes Myanmar. Eighteen the amphistomes, arbitrarily chosen, morphologically identified as E. explanatum...
The circadian clock is a cell-autonomous endogenous system that generates rhythms in the behavior and physiology of most organisms. We previously reported harmala alkaloid, harmine, lengthens period Bmal1 transcription NIH 3T3 fibroblasts. Clock protein dynamics were examined using real-time reporter assays PER2::LUC to determine effects harmine on central suprachiasmatic nucleus (SCN). Harmine significantly lengthened expression embryonic fibroblasts, neuronal cells differentiated from...
The olfactory epithelium and the vomeronasal organ of Japanese striped snake were examined by lectin histochemistry. Of 21 lectins used in study, all except succinylated-wheat germ agglutinin (s-WGA) showed similar binding patterns receptor cells with varying intensities. s-WGA varied among individuals cells, respectively. Four lectins, Bandeiraea simplicifolia lectin-II (BSL-II), Dolichos biflorus (DBA), Sophora japonica (SJA), Erythrina cristagalli (ECL) stained secretory granules...
Aspergillus flavus is an important zoonotic pathogen and a well-known aflatoxin producer. strains that are prevalent in Japanese environments reported to be non-aflatoxigenic, although their productivity, especially among clinical isolates, has not been thoroughly investigated date. In this study, we sequenced the genomes of ten A. isolated Japan compared sequences with each other as well those oryzae RIB40 NRRL3357. The phylogenetic analysis based on identified SNPs indicated five were...
Increasing use of zebrafish in biomedical, toxicological and developmental studies requires explicit knowledge cytochrome P450 (CYP), given the central role CYP oxidative biotransformation xenobiotics many regulatory molecules. A full complement genes their transcript expression during early development have already been examined. Here we established a comprehensive picture gene adult liver using RNA-seq technique. Transcriptional profiling revealed that CYP2AD2, CYP3A65, CYP1A, CYP2P9...
The pathogenesis of malaria parasites depends on host erythrocyte modifications that are facilitated by parasite proteins exported to the cytoplasm. These form a trafficking complex in cytoplasm transports virulence determinants surface; this is thus essential for virulence. Here, we report comprehensive interaction network map complex. We developed authentic, unbiased, highly sensitive proteomic approaches determine interact with core component complex, SBP1 (skeleton-binding protein 1)....
Abstract The vomeronasal organ (VNO) that preferentially detects species‐specific substances is diverse among animal species, and its morphological properties seem to reflect the ecological features of animals. This histological study two female reticulated giraffes ( Giraffa camelopardalis reticulata ) found VNO developed in giraffes. lateral medial regions lumen were covered with sensory nonsensory epithelia, respectively. glands positive for periodic acid‐Schiff alcian blue (pH 2.5)...
The morphology of the tetrapod nasal cavity has adapted to environment in terms olfaction and respiration. Reports indicate that internal structure green sea turtles is more complex than general, but whether or not it similar among turtle species remains unknown. present study aimed define structures (Chelonian mydas), loggerhead (Caretta caretta) leatherback (Dermochelys coriacea) using computed tomography. contained anterodorsal, anteroventral, posterodorsal diverticula a posteroventral...
The vomeronasal organ (VNO) detects specific chemicals such as pheromones and kairomones. Hedgehogs (Eulipotyphla: Erinaceidae) have a well-developed accessory olfactory bulb that receives projections from the VNO, but little is known about hedgehog VNO. Here, we studied histological features of VNO in five individual African pygmy hedgehogs by hematoxylin-eosin, periodic acid-Schiff, Alcian blue stains. comprises hyaline cartilage capsule, soft tissue epithelial lumen, it branches site just...
Due to the lack of efficacy currently used chemical drugs, poor tick control, and effective vaccines against
With 5 figures and tables Summary Seasonal changes in the histochemical properties of vomeronasal olfactory epithelia Japanese striped snake were examined four seasons, viz. reproductive, pre‐hibernating, hibernating post‐hibernating seasons. In supporting cells, secretory granules much more abundant season than other receptor lipofuscin fewer studies with 21 lectins, several lectins stained (receptor cells free border) weakly reproductive season. However, all both after sialic acid removal...
Although it has been commonly believed that birds are more dependent on the vision and audition than olfaction, recent studies indicate olfaction of is related to reproductive, homing, predatory behaviors. In an attempt reveal dependence olfactory system in crows, we examined Japanese jungle crow (Corvus macrorhynchos) by histological, ultrastructural, lectin histochemical methods. The epithelium (OE) occupied remarkably a small area nasal cavity (NC) had histological ultrastructural...
The olfactory system of mammals comprises a main that detects hundreds odorants and vomeronasal specific chemicals such as pheromones. (MOB) accessory (AOB) bulbs are the respective primary centers systems. Most including artiodactyls possess large MOB comparatively small AOB, whereas most cetaceans lack bulbs. common hippopotamus (<i>Hippopotamus amphibius</i>) is semiaquatic belongs to order Cetartiodactyla, family Hippopotamidae, which seems be closest extant cetaceans....