A5051623685- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Renin-Angiotensin System Studies
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Chromium effects and bioremediation
- Heavy Metal Exposure and Toxicity
- Hormonal Regulation and Hypertension
- Viral gastroenteritis research and epidemiology
- Mitochondrial Function and Pathology
- Immunotherapy and Immune Responses
- Genetic Associations and Epidemiology
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Metabolomics and Mass Spectrometry Studies
- Renal Transplantation Outcomes and Treatments
- Single-cell and spatial transcriptomics
- Air Quality and Health Impacts
- Systemic Lupus Erythematosus Research
- Pharmacological Effects and Assays
- Metabolism and Genetic Disorders
- Receptor Mechanisms and Signaling
- Mercury impact and mitigation studies
University of Alabama at Birmingham
2023-2025
University of Dhaka
2016-2023
Gifu University
2019-2023
Abstract Antigen-experienced memory B-cells (MBC) are endowed with enhanced functional properties compared to naïve B cells and play an important role in the humoral response. However, epigenetic enzymes programs that govern their rapid differentiation incompletely understood. Here, of histone H3 lysine 27 methyltransferase EZH2 formation MBC response influenza infection was determined Mus musculus. expressed all postactivated B-cell subsets, including antibody-secreting (ASC), maximal...
Glutathione S-transferases (GSTs) belong to a group of multigene detoxification enzymes, which defend cells against oxidative stress. Tannery workers are at risk damage that is usually detoxified by GSTs. This study investigated the genotypic frequencies GST Mu1 (GSTM1) and Theta1 (GSTT1) in Bangladeshi tannery healthy controls followed their status stress total activity. Of 188 individuals, 50.0% had both GSTM1 GSTT1 (+/+), 12.2% (+/−), 31.4% (−/+) alleles, 6.4% null genotypes (−/−) with...
Cardiovascular diseases (CVDs) are a group of disorders the heart and blood vessels. CVDs were responsible for approximately 31% all global deaths in 2016, 85% CVD due to attack stroke. The underlying process vessels that results stroke is atherosclerosis. A recent study indicated exposure environmental toxic heavy metals associated with an increased risk CVDs. In this review, we focus on several as factors CVDs: arsenic, lead, cadmium, mercury, chromium iron. pathological contribution these...
Abstract While mRNA vaccines have been effective in combating SARS-CoV-2, waning of vaccine-induced antibody responses and lack respiratory tract immunity contribute to ongoing infection transmission. In this work, we compare contrast intranasal (i.n.) intramuscular (i.m.) administration a SARS-CoV-2 self-amplifying RNA (saRNA) vaccine delivered by nanostructured lipid carrier (NLC). Both i.m. i.n. induce potent systemic serum neutralizing antibodies, bone marrow-resident IgG-secreting...
Occupational exposure to chromium used in mineral tanning processes cause adverse health effects on workers of leather industries. This study aimed evaluate the hematological and biochemical profiles tannery Hazaribagh, Bangladesh compared with a control group. A total 225 participants, 121 104 controls, were enrolled. All subjects completed interviewer-administered questionnaires; their physical was examined, blood samples collected parameters analyzed. The had mean duration work at...
SUMMARY Donor-specific antibody (DSA) responses against human leukocyte antigen (HLA) proteins mismatched between kidney transplant donors and recipients cause allograft loss. The rules governing the immunogenicity of non-self donor HLA are poorly understood. Using single-cell, molecular, structural, proteomic techniques, we profiled HLA-specific B cell response in blood a recipient with antibody-mediated rejection (AMR). We observed an immunodominant focused on topographically exposed,...
BackgroundPlasma renin can predict future cardiovascular events as well the prevalence of chronic renal disease in hypertensive subjects. Ovine angiotensinogen (oANG) is a better substrate for measuring concentration through activity assay. Recombinant oANG expressed Escherichia coli cells be utilized while plasma renin. We aim to establish an immunoassay at picomolar level using recombinant oANG.Material and methodsRecombinant was E. purified homogeneity. Various concentrations (0–1.5 pM)...
Abstract B cells can be divided into distinct subsets based on origin, activation history and functional attributes. Most human studies, which have characterized bulk polyclonal populations of circulating cells, suggest heterogeneity between the different cell subsets. Indeed, we showed that memory (Bmem) plasma from blood same donor exhibit patterns isotype distribution, mutational burden relatively limited clonal sharing. However, this may not extend to comparisons subset found within...
This study investigated distribution of HLA alleles (HLADRB1*01, *03, *04, *07, HLA-DQB1*0201, *0301/4) in 34 healthy controls and 57 rheumatoid arthritis (RA) patients a Bangladeshi population correlated the genotypic frequencies with clinical parameters. Frequency HLA-DRB1*04 (34%) HLA-DRB1*01 (32%) were highest followed by HLA-DQB1*0301/4 (29%) HLA-DQB1*0201 (26%) RA while HLA-DRB1*03 (12%) had lowest frequency. Plasma level anti-CCP factor antibodies confirmed diagnosis that varied...