A5049418840- Pain Management and Placebo Effect
- Complementary and Alternative Medicine Studies
- Growth Hormone and Insulin-like Growth Factors
- Empathy and Medical Education
- Genomics and Phylogenetic Studies
- Axon Guidance and Neuronal Signaling
- Acupuncture Treatment Research Studies
- Pituitary Gland Disorders and Treatments
- Diet and metabolism studies
- COVID-19 and healthcare impacts
- Intensive Care Unit Cognitive Disorders
- Chromosomal and Genetic Variations
- Infection Control and Ventilation
- Gastrointestinal motility and disorders
- Nutrition, Genetics, and Disease
- Vitamin C and Antioxidants Research
- Antioxidant Activity and Oxidative Stress
- Psychosomatic Disorders and Their Treatments
- Anesthesia and Sedative Agents
- Neuroscience, Education and Cognitive Function
- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Environmental Justice and Health Disparities
- Ion Channels and Receptors
- DNA Repair Mechanisms
Harvard University
2016-2025
Brigham and Women's Hospital
2016-2025
Boston Public Health Commission
2022-2025
New York Academy of Medicine
2025
Beth Israel Deaconess Medical Center
2012-2022
Medical College of Wisconsin
2020
Dow University of Health Sciences
2020
Mount Auburn Hospital
2020
Lemuel Shattuck Hospital
2018
Nepean Hospital
2018
Snakes possess many extreme morphological and physiological adaptations. Identification of the molecular basis these traits can provide novel understanding for vertebrate biology medicine. Here, we study snake using genome sequence Burmese python (Python molurus bivittatus), a model metabolic adaptation. We compare king cobra genomes along with genomic samples from other snakes perform transcriptome analysis to gain insights into phenotypes python. discovered rapid massive transcriptional...
In February 2022, Massachusetts rescinded a statewide universal masking policy in public schools, and many school districts lifted requirements during the subsequent weeks. greater Boston area, only two — neighboring Chelsea sustained through June 2022. The staggered lifting of provided an opportunity to examine effect policies on incidence coronavirus disease 2019 (Covid-19) schools.
Herein we describe the molecular characterization of human leukocyte activation antigen CD100 and identify it as first semaphorin, to our knowledge, in immune system. Semaphorins have recently been described neuronal chemorepellants that direct pioneering neurons during nervous system development. In this study demonstrate induces B cells aggregate improves their viability vitro. We show modifies CD40-CD40L B-cell signaling by augmenting aggregation survival down-regulating CD23 expression....
Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role processes associated with the effect such as reward, pain, memory learning. We hypothesized that COMT functional val158met polymorphism, was predictor of effects tested our hypothesis subset 104 from previously reported randomized controlled irritable bowel syndrome (IBS). The...
Among vertebrates, most of the largest genomes are found within salamanders, a clade amphibians that includes 613 species. Salamander genome sizes range from ∼14 to ∼120 Gb. Because size is correlated with nucleus and cell sizes, as well other traits, morphological evolution in salamanders has been profoundly affected by genomic gigantism. However, molecular mechanisms driving expansion this remain largely unknown. Here, we present first comparative analysis transposable element (TE) content...
Abstract It is commonly believed that blinding to treatment assignment necessary for placebos have an effect. However, administered without concealment (ie, open-label [OLPs]) recently been shown be effective in some conditions. This study had 2 objectives: first, determine whether OLP superior no-pill control (NPC) irritable bowel syndrome (IBS) and, second, compare the efficacy of against double-blind placebo (DBP). In a 6-week, 3-arm, randomized clinical trial, participants were equal...
Two ionizing radiation-sensitive (IRs) and DNA double-strand break (DSB) mutants, sxi-3 sxi-2, were shown to be severely deficient in a end binding activity, similar previously described activity of the Ku autoantigen, correlating with xrs (XRCC5) mutations. Cell fusions xrs-6, another IRs, DSB repair-deficient cell line, defined these sxi mutants XRCC5 group. cells have low expression levels p86Ku mRNA. Introduction p86 gene, but not p70 complemented binding, variable (diversity) joining...
We conducted a comprehensive assessment of genomic repeat content in two snake genomes, the venomous copperhead (Agkistrodon contortrix) and Burmese python (Python molurus bivittatus). These genomes are both relatively small (∼1.4 Gb) but have surprisingly extensive differences abundance expansion histories their elements. In python, readily identifiable element is low (21%), similar to bird whereas that higher (45%), mammalian genomes. The copperhead's greater arises from recent many...
Limited data exist regarding attitudes and acceptability of topical oral HIV pre-exposure prophylaxis (PrEP) among US black women. This investigation explored interest in chemoprophylaxis modes use. Five focus groups enrolled 26 women recruited from an inner-city community health center affiliated testing sites. Thematic analysis utilized Atlas.ti. Most expressed PrEP, as many reported condom failure concerns. preferred a pill formulation to intravaginal gel because greater perceived privacy...
Placebo medications, by definition, are composed of inactive ingredients that have no physiological effect on symptoms. Nonetheless, administration placebo in randomized controlled trials (RCTs) and clinical settings has been demonstrated to significant impact many physical psychological complaints. Until recently, conventional wisdom suggested patients must believe pills actually contain (or, at least, might possibly contain) active medication order elicit a response placebo. However,...
The placebo effect is a phenomenon in which patients who are given an inactive treatment (e.g., inert pill) show perceived or actual improvement medical condition. Placebo effects clinical trials have been investigated for many years especially because treatments often serve as the control arm of randomized trial designs. Recent observations suggest that may be modified by genetics. This observation has rise to term "placebome," refers group genome-related mediators affect individual's...
<h3>Importance</h3> Large placebo responses in randomized clinical trials may keep effective medication from reaching the market. Primary outcome measures of have shifted patient-reported to objective outcomes, partly because response treatment is thought be greater subjective compared with outcomes. However, a direct comparison and outcomes same patient population missing. <h3>Objective</h3> To assess whether (pain severity) inflammation (C-reactive protein [CRP] level erythrocyte...
Catechol-O-methyltransferase (COMT), a key enzyme in catecholamine metabolism, is implicated cardiovascular, sympathetic, and endocrine pathways. This study aimed to confirm preliminary association of COMT genetic variation with incident cardiovascular disease (CVD). It further evaluate whether aspirin, commonly used CVD prevention agent, modified the potential CVD.
Vitamins are among the most frequently used supplements (48% of US adults). However, little is known about contributions genetic variation to their efficacy and safety. Multiple pathways link catechol-O-methyltransferase (COMT) vitamin E supplement, alpha-tocopherol, cancer.
Efficacy of aspirin in primary prevention cardiovascular disease (CVD) may be influenced by a common allele guanylate cyclase GUCY1A3, which has been shown to modify platelet function and increase CVD risk.We investigated whether homozygotes the GUCY1A3 rs7692387 risk (G) benefited from two long-term, randomized placebo-controlled trials prevention: Women's Genome Health Study (WGHS, N = 23 294) myocardial infarction (MI, 550) stroke (N 382) case-control set Physician's (PHS, 22 071)....