A5016640952- Osteoarthritis Treatment and Mechanisms
- Rheumatoid Arthritis Research and Therapies
- Orthopaedic implants and arthroplasty
- Ion channel regulation and function
- Systemic Lupus Erythematosus Research
- Bone and Joint Diseases
- Chronic Lymphocytic Leukemia Research
- Neurobiology and Insect Physiology Research
- Knee injuries and reconstruction techniques
- Hip disorders and treatments
- Radiation Dose and Imaging
- Periodontal Regeneration and Treatments
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Biosimilars and Bioanalytical Methods
- Cervical and Thoracic Myelopathy
- Lower Extremity Biomechanics and Pathologies
- Orthopedic Surgery and Rehabilitation
- Blood groups and transfusion
- Musculoskeletal synovial abnormalities and treatments
- Monoclonal and Polyclonal Antibodies Research
- Dental Implant Techniques and Outcomes
- Spinal Fractures and Fixation Techniques
- thermodynamics and calorimetric analyses
- Adenosine and Purinergic Signaling
Shiga University of Medical Science
2013-2023
Shiga University
2008-2018
University Medical Center Utrecht
2009
ObjectiveThe anterior cruciate ligament transection (ACLT) rabbit osteoarthritis (OA) model confers permanent knee instability and induces joint degeneration. The degeneration process is complex, but includes chondrocyte apoptosis OA-like loss of cartilage integrity. Previously, we reported that activation a volume-sensitive Cl− current (ICl,vol) can mediate cell shrinkage in articular chondrocytes. Our objective was therefore to investigate whether ICl,vol activated the early stages ACLT OA...
BACKGROUND AND PURPOSE Chondrocyte apoptosis contributes to disruption of cartilage integrity in osteoarthritis. Recent evidence suggested that the volume-sensitive organic osmolyte/anion channel [volume-sensitive (outwardly rectifying) Cl(-) current (I(Cl,vol) )] plays a functional role development cell shrinkage associated with (apoptotic volume decrease) several types. In this study, we investigated cellular effects 17β-oestradiol on doxorubicin-induced apoptotic responses rabbit...
Abstract Articular cartilage has a poor healing capacity, and regeneration is not always warranted to achieve healing. On the other hand, collagen scaffolds have been shown support of articular defects in animal models, whereas bone morphogenetic protein‐2 (BMP‐2) known cause chondrogenic differentiation marrow‐derived mesenchymal stem cells (MSCs). The purpose this study was evaluate effectiveness intra‐articular administration BMP‐2 into marrow–derived MSCs recruited using original...
Articular chondrocytes are exposed in vivo to the continually changing osmotic environment and thus require volume regulatory mechanisms. The present study was designed investigate (i) functional role of swelling-activated Cl(-) current (I(Cl,swell)) decrease (RVD) (ii) tyrosine phosphorylation I(Cl,swell), isolated rabbit articular chondrocytes. Whole-cell membrane currents were recorded from isosmotic, hyposmotic hyperosmotic external solutions under conditions where Na(+), K(+) Ca(2+)...
Chondrocyte apoptosis contributes to the disruption of cartilage integrity in osteoarthritis (OA). Recently, we reported that activation volume-sensitive Cl- current (ICl,vol) mediates cell shrinkage, triggering rabbit articular chondrocytes. A cyclooxygenase (COX) blocker is frequently used for treatment OA. In present study, examined vitro effects selective blockers COX on TNFα-induced ICl,vol chondrocytes using patch-clamp technique. Exposure isolated TNFα resulted an obvious increase...
Histological, immunohistochemical, and suspension array analyses of cytokine expression in human cervical ossification the posterior longitudinal ligament (OPLL).The aim this study was to determine whether changes profile reflect maturation chondrocytes osteoblasts are associated with OPLL development.OPLL progresses gradually over a prolonged period may lead serious spinal cord complications. However, treatment methods only include conservative therapy for neurological symptoms or surgical...
Prolonged dislocation of the patella is a rare condition and often related to severe osteoarthritis (OA) femorotibial (FT) joint. For this condition's treatment, numerous surgical techniques using total knee arthroplasty (TKA) have been published. To best our knowledge, case report first description use lateral release alone treat recurrent patellar subluxation with TKA. An interesting point in that patient had good recovery after TKA spite quite long-term (a duration almost 55 years) her...
Purpose: Rheumatoid arthritis (RA) patients with secondary osteoarthritis (OA) in a knee joint following total arthroplasty (TKA) procedure have been increasing. Here, we investigated osteophyte formation joints of RA and associated factors. Methods: We retrospectively examined findings 35 knees 30 (26 females, 4 males; mean age: 63.0 years; median disease duration: 15 years) who underwent TKA, including preoperative anteroposterior view radiographs the joint. Using ImageJ software package,...
Elderly-onset rheumatoid arthritis (EORA) is reported to differ from young-onset (YORA) with regard patient background and drug treatment. We examined the amount of administered patients who achieved low disease activity (LDA) for at our hospital.Demographics, clinical history, treatments were compared between EORA (n = 70) YORA 190).There was a significant difference in average age (73.8 vs. 57.8 years), duration (6.66 14.7 sex (62.9% males 83.7% females), but no factor positivity (85.3%...
ABSTRACT Objectives The aim of the article is to investigate associations disease duration and anti-cyclic citrullinated peptide antibody (ACPA) status with effectiveness abatacept in biologic-naïve patients rheumatoid arthritis (RA). Methods We performed post hoc analyses Orencia® Registry Geographically Assembled Multicenter Investigation (ORIGAMI) study RA aged ≥20 years moderate activity who were prescribed abatacept. Changes Simplified Disease Activity Index (SDAI) Japanese Health...
Ischiofemoral space (IFS) is a radiological parameter employed for diagnosing ischiofemoral impingement (IFI). The mean IFS value measured with the leg in natural resting position has been reported as 23.0 mm males and 18.6 females patients-based Western population. normal of an Asian population unknown. This study therefore aimed to investigate whether Japanese hip joints equals that We retrospectively examined 89 consecutive individuals (178 hips) (46 male subjects 92 hips, 43 female 86...
<h3>Background</h3> Along with the present aging population, development of new therapies such as biological disease-modifying anti-rheumatic drugs for rheumatoid arthritis (RA) has resulted in an increasing number elderly patients RA seeking treatment. Furthermore, onset age been reported to be trending higher. Elderly (EORA) is defined that which develops after 60 years age, and shown differ from young (YORA) regard background drug treatment.<sup>1</sup> Although many EORA cases have acute...
ABSTRACT In rheumatoid arthritis (RA), it is important to actively treat wrist dysfunction improve patient outcomes. Herein, we report two cases of in RA patients who required partial fusion soon after drug initiation. Case 1: A 38-year-old woman was referred our hospital because left joint pain. At the time examination, swelling and tenderness were observed. After 6 months medication, no improvement symptoms noted; therefore, performed. 2: right plain X-ray image showed carpal bones. Due...
<h3>Background</h3> Recent clinical trials of biologic agents have reported that radiographic evidence healing was seen in patients with rheumatoid arthritis (RA) who were remission. However, those results limited to small joints (hand and foot), while the effects on large weight-bearing (hip knee) not been clarified. Some other investigators reported<sup>1)</sup> all hip knee examined pre-existing damage rated as Larsen grade<sup>2)</sup> III/IV showed joint-damage progression, even a good...
<h3>Background</h3> Some recent reports indicate that the number of total hip arthroplasty (THA) procedures for RA patients worldwide has been decreasing in years. Bone destruction inhibition by use methotrexate (MTX) and biological drugs suggested as a possible reason. However, few studies have investigated whether joint was altered treatment with such new drugs. <h3>Objectives</h3> The purpose this study to examine cases requiring THA shown trend, identify any reason change....
<h3>Background</h3> A reduction in complement levels during anti-TNF treatment patients with rheumatoid arthritis (RA) has been described. However, there are no reports regarding changes the use of Tocilizumab (TCZ). <h3>Objectives</h3> In this study, we investigated TCZ and compared them to those RA. <h3>Methods</h3> We measured C3 C4 25 treated 44 anti-TNF. addition, major disease activity indicators were monitored before 1 year after initiation treatment. <h3>Results</h3> Disease...
<h3>Background</h3> Hip joints are important for daily like activities, which become limited when destruction occurs. Joint caused by rheumatoid arthritis (RA) can be administration of a biological drug, thus it is considered that the number surgeries affected patients will decrease in future, with some recent reports noting total hip arthroplasty (THA) procedures RA decreasing. Bone inhibition use methotrexate (MTX) and drugs has been suggested. However, few studies have investigated...