A5059406352- Immune Cell Function and Interaction
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Plant biochemistry and biosynthesis
- Business, Innovation, and Economy
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Animal Disease Management and Epidemiology
- Epigenetics and DNA Methylation
- Animal Virus Infections Studies
- Glycosylation and Glycoproteins Research
- Bioactive Compounds and Antitumor Agents
- Business, Education, Mathematics Research
- Diverse Applied Research Studies
- Virology and Viral Diseases
- Bioactive Natural Diterpenoids Research
- vaccines and immunoinformatics approaches
- Immune responses and vaccinations
- Higher Education and Sustainability
- Cytokine Signaling Pathways and Interactions
- Viral Infections and Outbreaks Research
- Building Energy and Comfort Optimization
- Mosquito-borne diseases and control
- Caveolin-1 and cellular processes
- Hepatitis C virus research
Universidade Federal do Triângulo Mineiro
2017-2023
Universidade Federal do Rio de Janeiro
2012-2017
University of Rostock
2012
Universidade Federal de Juiz de Fora
2012
The ability of HIV to establish long-lived latent infection is mainly due transcriptional silencing viral genome in resting memory T lymphocytes. Here, we show that new semi-synthetic ingenol esters reactivate reservoirs. Amongst the tested compounds, 3-caproyl-ingenol (ING B) was more potent reactivating than known activators such as SAHA, 3,20-dibenzoate, TNF-α, PMA and HMBA. ING B activated PKC isoforms followed by NF-κB nuclear translocation. As virus reactivation dependent on intact...
The aim of this work was to analyze terpene oil production and synthases (TPS) gene expression from leaves at different developmental stages chemotypes Lippia alba (Mill.) N.E. Br. ex Britton & P. Wilson, Verbenaceae. Hydro-distilled essential were used for chemical analysis three monoterpene synthase genes called LaTPS12, LaTPS23 LaTPS25 analyses associated production. putative TPS-b class. Semi-quantitative PCR quantitative (qPCR) investigate the profile those in leaf chemotypes....
SARS-CoV-2 is the etiological agent of COVID-19, which represents a global health emergency that was rapidly declared pandemic by World Health Organization. Currently, there dearth effective targeted therapies against viruses. Natural products isolated from traditional herbal plants have had huge impact on drug development aimed at various diseases. Lapachol 1,4- naphthoquinone compound has been demonstrated to therapeutic effects several non-structural proteins (nsps) play an important role...
Interferon-γ (IFNγ)-mediated signal transduction via upregulation of transducer and activator transcription (STAT) 1 leads to the expression mucin (MUC) 4 gene in pancreatic cancer cells. Upregulation STAT1 may also implicate tyrosine- or serine-phosphorylation. Experimental data indicate that reaction steps involved IFNγ-induced serine-phosphorylation vary between cell types contrast conserved tyrosine-phosphorylation STAT1. The above observations raise following two questions: (i) How does...
Hepatitis C virus (HCV) is responsible for more than 180 million infections worldwide, and about 80 % of are reported in Low Middle-income countries (LMICs). Therapy based on the administration interferon (INF), ribavirin (RBV) or recently Direct-Acting Antivirals (DAAs). However, amino acid substitutions associated with resistance (RAS) have been extensively described can contribute to treatment failure, diagnosis RAS requires considerable infrastructure, not always locally available. Dried...
Since the beginning of SARS-CoV-2 spread in Brazil, few studies have been published analysing variability viral genome. Herein, we described dynamic strains circulating Brazil from May to September 2020, better understand changes that may affect ongoing pandemic. Our data demonstrate some mutations identified are currently observed variants interest and concern, emphasize importance studying previous periods order comprehend emergence new variants. From 720 genome sequences, found sites...
Lippia lacunosa is a Brazilian savanna plant that belongs to the Verbenaceae family. It has been used in folk medicine as treatment for different diseases. This species represents an endangered medicinal plant, and this first report documenting reliable protocol vitro propagation regeneration of L. lacunosa. Axenic explants were cultivated MS medium containing concentrations naphthalene acetic acid (NAA) induce root growth. The mean shoot length number roots highest with 0.06 mg·L-1 NAA....
The genus Mammarenavirus belonging to the family Arenaviridae encompasses pathogenic viral species capable of triggering severe diseases in humans, causing concern for health system due high fatality rate associated with them. Currently, there is a dearth specific therapies against pathogens genus. Natural products isolated from plants have impacted development drugs several diseases. Núcleo de Bioensaios, Biossíntese e Ecofisiologia Produtos Naturais (NuBBE) database offers natural...
Peptides generated from cellular protein degradation via the ubiquitin-proteasome pathway are presented on MHC class I as a means for immune system to monitor polypeptides being synthesized by cells. For CD8 + T cells prevent spread of an incipient infection, it appears essential they should be able sense foreign soon possible. A prompt detection viral proteins is great importance success adaptive response. Defective ribosomal products (DRiPs) have been postulated preferential source which...
During the early stages of HIV infections, virus establishes latency in a portion population infected long-lived memory cells CD4+. Such latent viral reservoirs are inaccessible to standard antiretroviral drugs and result an inability eradicate infection. A reactivation would offer opportunity expose it action (HAART) consequently lead full elimination virus. We have found that esters ingenol E. tirucalli act as reactivators HIV. They were isolated by Centrifugal Partition Chromatography...