A5089673148- Neural and Behavioral Psychology Studies
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Functional Brain Connectivity Studies
- Glycosylation and Glycoproteins Research
- Alzheimer's disease research and treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Lymphatic System and Diseases
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Vitamin C and Antioxidants Research
- Galectins and Cancer Biology
- Clostridium difficile and Clostridium perfringens research
- Schizophrenia research and treatment
- Theological Perspectives and Practices
- Frailty in Older Adults
- Monoclonal and Polyclonal Antibodies Research
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Myasthenia Gravis and Thymoma
- Uterine Myomas and Treatments
- Genetic factors in colorectal cancer
Ruhr University Bochum
2017-2025
Hudson Institute
2025
Technische Hochschule Georg Agricola
2025
University Hospital Bonn
2019-2024
University of Copenhagen
2023-2024
VA Pittsburgh Healthcare System
2016-2023
VA Healthcare-VISN 4
2019-2023
Mental Illness Research, Education and Clinical Centers
2021-2023
BG University Hospital Bergmannsheil Bochum
2017-2023
University of Pittsburgh
2010-2022
Objective: Deficits in working memory and cognitive control schizophrenia are associated with impairments prefrontal cortical function, including altered gamma band oscillations. These abnormalities thought to reflect a deficiency the synchronization of pyramidal cell activity that is dependent, part, on gamma-aminobutyric acid (GABA) neurotransmission through GABA type A (GABA ) receptors containing α 2 subunits. The authors conducted proof-of-concept clinical trial designed test hypothesis...
Mechanisms by which the brain monitors and modulates performance are an important focus of recent research. The conflict-monitoring hypothesis posits that ACC detects conflict between competing response pathways which, in turn, signals for enhanced control. N2, ERP component has been localized to ACC, observed after high stimuli. As a candidate index signal, N2 would be expected sensitive degree present, factor depends on both features external stimuli internal control state. In present...
Abstract Background Fecal microbiota transplantation (FMT) and fecal virome (FVT, sterile filtrated donor feces) have been effective in treating recurrent Clostridioides difficile infections, possibly through bacteriophage-mediated modulation of the gut microbiome. However, challenges like variability, costly screening, coupled with concerns over pathogen transfer (incl. eukaryotic viruses) FMT or FVT hinder their wider clinical application less acute diseases. Methods To overcome these...
Abstract While aberrant protein glycosylation is a recognized characteristic of human cancers, advances in glycoanalytics continue to discover new associations between glycoproteins and tumorigenesis. This glycomics‐centric study investigates possible link paucimannosylation, an under‐studied class N ‐glycosylation [Man 1‐3 GlcNAc 2 Fuc 0‐1 ], cancer. The paucimannosidic glycans (PMGs) 34 cancer cell lines 133 tissue samples spanning 11 types matching non‐cancerous specimens are profiled...
Abstract Background Undenutrition is known to be prevalent and largely unrecognised in older patients; however, aberrations indicators of nutritional status may simply reflect effects age and/or functional disability. Objective The aim this study was measure the effect, if any on patients. Design 445 randomly selected hospitalised patients consented assessment derived from anthropometric, haematological, biochemical data within 72 hours admission. Nutritional compared between those < 75...
Efzofitimod is a first-in-class biologic based on naturally occurring splice variant of histidyl-tRNA synthetase (HARS) that downregulates immune responses via selective modulation neuropilin-2 (NRP2). Preclinical data found high expression NRP2 in sarcoidosis granulomas. Treatment with efzofitimod reduced the granulomatous inflammation induced by P. acnes an animal model sarcoidosis. A dose escalating trial chronic symptomatic pulmonary disease treatment was associated improved quality life...
Abstract Background and aims A higher dietary protein intake has overall health body composition benefits but also the propensity to drive inflammation in ulcerative colitis (UC). This study investigate whether recreational animal-based supplementation affects ability maintain remission adults with clinically quiescent UC. Methods Twenty-four UC (Simple Clinical Colitis Activity Index (SCCAI) ≤2) on stable therapy will be randomised a 24-week double blind, parallel, placebo-controlled...
There has been accumulating evidence that cognitive control can be adaptively regulated by monitoring for processing conflict as an index of online demands. However, it is not yet known whether top-down mechanisms respond to in a manner specific the operative task context or confer more generalized benefit. While previous studies have examined taskset-specificity adaptation effects, yielding inconsistent results, control-related performance adjustments following errors largely overlooked....
Dietary assessment in older adults can be challenging. The Novel Assessment of Nutrition and Ageing (NANA) method is a touch-screen computer-based food record that enables to their dietary intakes. objective the present study was assess relative validity NANA for adults. For this purpose, three studies were conducted which total ninety-four (aged 65–89 years) used assessment. On separate occasion, participants completed 4 d estimated diary. Blood 24 h urine samples also collected from...
Our objective was to determine the role of Rho-associated kinase (ROK) for regulation FBF (FBF) and unmask a potential ROK endothelium-derived nitric oxide (NO). Moreover, effect fasudil on constrictor response endothelin-1 recorded. Regarding background, phosphorylation myosin light chain (MLC) determines calcium sensitivity contractile apparatus. MLC depends activity phosphatase. The latter enzyme is inhibited through by ROK. has been suggested inhibit NO generation, possibly via...
The success of a human intervention trial depends upon the ability to recruit eligible volunteers. Many trials fail because unrealistic recruitment targets and flawed strategies. In order predict rates accurately, researchers need information on relative various Few published include such number participants screened or approached is not always cited. This paper will describe in detail strategies employed identify older adults for 6-month randomised controlled dietary which aimed explore...