A5003091728- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Microbial infections and disease research
- Burkholderia infections and melioidosis
- Diagnosis and treatment of tuberculosis
- Bacteriophages and microbial interactions
- Ginseng Biological Effects and Applications
- Infectious Diseases and Tuberculosis
- Infectious Diseases and Mycology
- vaccines and immunoinformatics approaches
- Pharmacological Effects of Natural Compounds
- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- Zoonotic diseases and public health
- Phytochemistry and biological activities of Ficus species
- Pneumonia and Respiratory Infections
- Microbial Metabolism and Applications
- Plant Pathogenic Bacteria Studies
- Immune responses and vaccinations
- Vibrio bacteria research studies
- Aquaculture disease management and microbiota
- Antibiotic Resistance in Bacteria
- Monoclonal and Polyclonal Antibodies Research
- Brucella: diagnosis, epidemiology, treatment
- Veterinary medicine and infectious diseases
Razi Vaccine and Serum Research Institute
2015-2024
Agricultural Research & Education Organization
2016-2024
Shiraz University
2016
Qom Islamic Azad University
2013
Islamic Azad University, Karaj
2013
Shahid Chamran University of Ahvaz
2011
Isfahan University of Medical Sciences
2008
Hess (United States)
2007
Inflammatory bowel disease (IBD) is described as a relapsing condition with high morbidity and uncertain complex pathogenesis. The association of Mycobacterium avium ssp. paratuberculosis (MAP) Crohn's (CD) in human has been debated for decades, however there no confirmed data to verify such relations Iran. aim this study was investigate risk factors possible role MAP Iranian patients CD.Anti-MAP antibodies were detected serum IBD subjects without (nIBD) through ELISA; DNA viable cells...
Amphotericin B (AmB) is an effective antifungal agent; however, the application of AmB associated with a number drawbacks. Application nanoparticles (NPs) known to improve efficiency drug delivery target tissues, compared traditional methods. In this study, novel method NPs preparation was developed. The trimethyl chitosan (TMC) synthesized using low molecular weight and used for TMC-NPs through ionic gelation method. Afterward, AmB-loaded (TMC-NPs/AmB) were prepared their potential testes....
Humans have been in a constant battle with tuberculosis (TB). Currently, overuse of antibiotics has resulted the spread multidrug-resistant Mycobacterium (MDR), leading to antibiotic ineffectiveness at controlling TB infection host cells and especially macrophages. Additionally, (Mtb) developed methods evade immune system survive. With discovery nanoparticle (NP)-based drugs, it is necessary research their anti-mycobacterial properties bactericidal mechanisms. In this study, we synthesized...
Introduction The early secreted antigenic target 6-kDa protein (ESAT-6) plays an important role in immune protection against Tuberculosis. Owing to its great potential increase response, chitosan can be considered as a suitable biodegradable polymer for intranasal administration. Methods physiochemical properties of the nanoparticle were measured vitro. Two weeks after last administration, blood samples collected and specific IgG, IFN-gama, IL-4 levels by ELISA. Results Chitosan...
INTRODUCTION Characterization of Mycobacterium tuberculosis (MTB) isolates by DNA fingerprinting has contributed to (TB) control. The aim this study was determine the genetic diversity MTB from Tehran province in Iran. METHODS 60 Iranian and 10 Afghan TB patients were fingerprinted standard IS6110-restriction fragment length polymorphism (RFLP) analysis spoligotyping. RESULTS copy number IS6110 ranged 10-24 per isolate. classified into 22 clusters showing ≥ 80% similarity RFLP analysis....
Bovine tuberculosis (BTb) is mainly a disease of cattle, although it continues to infect human populations across the world. Operation test and slaughter plan in Iran since 1981 has lowered frequency BTb from >5% <0.14% at national scale. In 2015, unusual uncontrollable epidemics were detected two cattle farms municipal suburbs Qazvin Isfahan. These had tuberculin-test-certified record BTb-free status for past 5 consecutive years, with no new registered either herds during this time period....
Abstract To identify strains of Mycobacterium bovis circulating in Iran, we used region difference, spoligotypes, and variable number tandem repeats to genotype 132 M. isolates from Holstein Friesian cattle. Despite wide geographic origins, the were genetically homogeneous. Increased distribution cattle herds inadequate control measures may have contributed strain dispersion.
The World Health Organization acknowledges tuberculosis as a global threat. Tuberculosis infection is one of the top 10 causes death worldwide. Nanotechnology and microbiology researchers are looking for new safe nano drugs eliminating Mycobacterium , causative agent tuberculosis. In this study, AgZnO nano‐crystals (AgZnONCs) synthesized via decomposition precursor oxalate method. Characterization AgZnONCs were evaluated. Next, various concentrations AgZnONCs, well AgZnONCs+Rifampicin,...
A nanodiagnostic method using nucleic acid sequence-based amplification (NASBA) and gold nanoparticle probes (AuNP probes) was developed for colorimetric detection of Mycobacterium tuberculosis. The primers targeting 16S rRNA were used the mycobacterial RNA by isothermal NASBA process. amplicons hybridized with specific probes. RNA–DNA hybrids colorimetrically detected accumulation nanoparticles. Using this method, 10 CFU ml−1 M. tuberculosis within less than 1 h. Results obtained from...
Background: Tuberculosis remains a major global threat. Two billion of the world's population is latently infected with Mycobacterium tuberculosis and at risk progression to active disease. Bacillus Calmette-Guerin (BCG), as only licensed vaccine, has prophylaxis strategy, which protects children from disseminated form tuberculosis. Therefore, postexposure vaccine targets individuals latent infection, an important strategy control this disease globally. Objectives: In present study, we...
Introduction: Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of or Johne’s disease in ruminants. Its role triggering autoimmunity, including type 1 diabetes mellitus (T1DM), has been reported recent years. Due to high contamination rate MAP Iran’s livestock and increasing outbreak T1DM, we investigated this association a small group patients with T1DM Iran. Methodology: Blood samples 29 healthy control subjects were tested through enzyme-linked immunosorbent assay...
The potentially pathogenic Non-Tuberculosis Mycobacteria (NTM) are emerging nowadays which result in pulmonary and non-pulmonary infections human. This group of bacteria consists at least 200 different species. While the disease is most common form NTM infections, can cause diffused as well extrapulmonary every organ, such bone marrow, skin, eye, brain. tuberculosis-like therefore, correct identification these necessary to avoid faulty treatment. Different species isolates were identified...
Background: Molecular typing techniques are reliable tools for epidemiological study of tuberculosis because their power in detecting recent transmission and differentiating reinfection relapses. Objectives: The present investigated diversity among Mycobacterium strains circulating three Khorasan provinces, Iran, using 12-loci MIRU-VNTR spoligotyping. Methods: This was performed on 140 M. selected from the sputum new cases pulmonary patients Iran. 12 loci Spoligotyping were all isolates....