A5036463370- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Trauma and Emergency Care Studies
- Healthcare Systems and Practices
- Neurosurgical Procedures and Complications
- Health Systems, Economic Evaluations, Quality of Life
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Procedures and Complications
- Cerebral Venous Sinus Thrombosis
- Neurological Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Case Reports on Hematomas
- Spinal Hematomas and Complications
- Medicine and Dermatology Studies History
- Neuroscience of respiration and sleep
- Cerebrovascular and genetic disorders
- Vascular Anomalies and Treatments
- Patient-Provider Communication in Healthcare
University of Chicago
2009-2024
University of Chicago Medical Center
2023
Clinical Research Institute
2022
University of Calgary
2022
Harvard University
2022
Massachusetts General Hospital
2022
University of California, Los Angeles
2022
Northwestern University
2016-2020
Lurie Children's Hospital
2020
University of Miami
2020
The use of covered stent grafts for the treatment carotid rupture is increasingly being used given their ability to preserve parent artery while simultaneously occluding fistula or point.
Endovascular therapy (EVT) improves functional outcomes in acute ischemic stroke (AIS) with large vessel occlusion (LVO). Whether implementation of a regional prehospital transport policy for comprehensive center triage increases use EVT is uncertain.To evaluate the association that directly triages patients suspected LVO to nearest rates EVT.This retrospective, multicenter preimplementation-postimplementation study used an interrupted time series analysis compare treatment before and after...
Prior regional or single-center studies have noted that 4% to 7% of eligible patients with acute ischemic stroke (AIS) decline IV tissue plasminogen activator (tPA). We sought determine the prevalence tPA declination in a nationwide registry AIS and investigate differences by race/ethnicity.We used Get With The Guidelines-Stroke identify for admitted participating hospitals between January 1, 2016, March 28, 2019. compared patient demographics admitting hospital characteristics tPA-eligible...
Background and Purpose: Accurate prehospital diagnosis of stroke by emergency medical services (EMS) can increase treatments rates, mitigate disability, reduce deaths. We aimed to develop a model that utilizes natural language processing EMS reports machine learning improve identification. Methods: conducted retrospective study patients transported the Chicago 17 regional primary comprehensive centers. Patients who were suspected or had hospital-diagnosed included in our cohort. Text within...
<h3>Objective</h3> To evaluate race differences in tissue plasminogen activator (tPA) refusal among eligible patients with acute ischemic stroke (AIS) Chicago. <h3>Methods</h3> Using the Get With The Guidelines–Stroke registry data from 15 primary centers between January 2013 and June 2015, we performed a retrospective analysis of AIS presenting to emergency department within 4.5 hours symptom onset. Patient or proxy was captured as reason for nonadministration tPA registry. We assessed...
Background and Purpose— No standard approach to obtaining informed consent for stroke thrombolysis with tPA (tissue-type plasminogen activator) currently exists. We aimed assess current nationwide practice patterns of tPA. Methods— An online survey was developed distributed by e-mail clinicians involved in acute care. Multivariable logistic regression analyses were performed determine independent factors contributing always Results— Among 268 respondents, 36.7% reported 51.8% the process...
Background Patients with acute stroke at non- or primary centers (PSCs) are transferred to comprehensive for advanced treatments that reduce disability but experience significant delays in treatment and increased adjusted mortality. This study reports the results of a proactive, systematic, risk assessment door-in-door-out process its application solution design. Methods Results A learning collaborative (clinicians, patients, caregivers) 2 PSCs 3 Chicago, Illinois participated failure modes,...
Background Acute ischemic stroke (AIS) due to intracranial atherosclerotic disease (ICAD) carries a high risk of recurrence despite aggressive medical management. The aim our study is present initial experience with the Onyx Frontier™ balloon-mounted drug-eluting stent (Medtronic, Santa Rosa, CA) for AIS ICAD. Methods We conducted multicenter retrospective cohort describing technical feasibility, safety, and performance using in patients acute vessel occlusion ICAD across three comprehensive...
We present a 35-year-old male with ulcerative colitis initially admitted for flare-up who then presented altered mental status and was found to have extensive cerebral venous sinus thrombosis on computed tomography imaging. The patient underwent successful partial recanalization of the superior sagittal bilateral transverse sinuses using Penumbra Indigo® Aspiration System improved outcomes. To our knowledge, this is first reported use device in treatment thrombosis.
The transradial approach (TRA) for neurointerventional procedures is increasingly being used given its technical feasibility and safety. However, catheter trackability device deliverability are reported barriers to TRA adoption.
Background The optimal antiplatelet therapy regimen for certain neuroendovascular procedures remains unclear. This study investigates the safety and feasibility of intravenous dose-adjusted cangrelor in patients undergoing acute interventions. Methods We conducted a retrospective chart review all consecutive on between September 1, 2020, March 13, 2022. also an updated systematic meta-analysis using PubMed, Scopus, Web Science, Embase Cochrane Library up to February 22, 2023. Results In our...
Background and Purpose- A quarter of acute strokes occur in patients hospitalized for another reason. stroke recognition instrument may be useful non-neurologists to discern from mimics such as seizures or delirium. We aimed derive validate a clinical score distinguish among inhospital suspected strokes. Methods- reviewed consecutive inpatient alerts single academic center January 9, 2014, December 7, 2016. Data points, including demographics, risk factors, alert reason, postoperative...
Current published guidelines and meta-analyses comparing endovascular thrombectomy (EVT) alone versus EVT with bridging intravenous thrombolysis (IVT) suggest that is non-inferior to in achieving favourable functional outcome. Because of this controversy, we aimed systematically update the evidence meta-analyse data from randomised trials thrombolysis, performed an economic evaluation both strategies.We will conduct a systematic review controlled or without patients presenting large vessel...
<h3>Introduction</h3> Chronic subdural hematomas (SDH) have a higher prevalence among the elderly population and can cause significant morbidity mortality when they recur after surgical intervention. Use of n-butyl-2-cyanoacrylate (n-BCA) has proven to be an effective safe therapeutic agent for embolization middle meningeal artery (MMA). In our study, we present retrospective analysis 31 patients who underwent MMA chronic SDH. <h3>Methods</h3> prospectively maintained database in single...
<b><i>Background:</i></b> There is unclear added benefit of intravenous thrombolysis (IVT) with endovascular thrombectomy (EVT). We performed a cost-effectiveness analysis to assess the comparing EVT IVT versus alone. <b><i>Methods:</i></b> used decision tree examine short-term costs and outcomes at 90 days after occurrence index stroke compare alone plus for patients stroke. Subsequently, we developed Markov state transition model over 1-year,...
To assess the risk of subsequent stroke among older patients discharged from an emergency department (ED) without a diagnosis TIA or stroke.Using electronic health record data large urban, university hospital and community-based hospital, we analyzed aged 60-89 years to home ED International Statistical Classification Diseases Related Health Problems, 9th 10th Revision stroke. Based on presence/absence head CT chief complaint suggestive ("symptoms") during index visit, created 4 mutually...
The raphe magnus (RM) participates in opioid analgesia and contains pain-modulatory neurons with respiration-related discharge. Here, we asked whether RM contributes to respiratory depression, the most prevalent lethal effect of opioids. To investigate opioidergic transmission produces microinjected a mu-opioid receptor agonist, DAMGO, or morphine into awake rodents. In mice, microinjection produced sustained decreases rate (170 120 breaths/min), as well heart (520 400 beats/min)....