A5006704772- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Bone Tumor Diagnosis and Treatments
- Advanced MRI Techniques and Applications
- Oral and Maxillofacial Pathology
- Pancreatic and Hepatic Oncology Research
- Sarcoma Diagnosis and Treatment
- Bone and Joint Diseases
- Radiation Dose and Imaging
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Ocular Oncology and Treatments
- Lung Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- LGBTQ Health, Identity, and Policy
- Head and Neck Cancer Studies
- Glaucoma and retinal disorders
- Ocular Infections and Treatments
- Soft tissue tumor case studies
- Multiple and Secondary Primary Cancers
National Center for Oncological Hadrontherapy
2016-2025
Marche Polytechnic University
2020-2023
Collaborative Group (United States)
2022
University of Florence
2021
Heidelberg University
2019
National Center for Tumor Diseases
2019
German Cancer Research Center
2019
Politecnico di Milano
1994-2013
Skull-base chordoma (SBC) can be treated with carbon ion radiotherapy (CIRT) to improve local control (LC). The study aimed explore the role of multi-parametric radiomic, dosiomic and clinical features as prognostic factors for LC in SBC patients undergoing CIRT. Before CIRT, 57 underwent MR CT imaging, from which tumour contours dose maps were obtained. MRI CT-based selected fed two survival models, singularly or by combining them factors. Adverse was given in-field recurrence progression....
ABSTRACT Background Lenvatinib, a multi‐target tyrosine kinase inhibitor (MTKI), has demonstrated activity in recurrent or metastatic (R/M) adenoid cystic carcinoma (ACC) phase II studies. Methods This multicenter, retrospective study included patients with R/M ACC treated lenvatinib. The primary endpoint was the overall response rate (ORR). Results Fifty‐one were across 17 Italian sites. Forty‐six (90%) evaluated for response: ORR 21.7%, 10 achieving partial response; 24 had stable disease...
In an increasing number of clinical indications, radiotherapy with accelerated particles shows relevant advantages when compared high energy X-ray irradiation. However, due to the finite range ions, particle therapy can be severely compromised by setup errors and geometric uncertainties. The purpose this work is describe commissioning design quality assurance procedures for patient positioning verification systems at Italian National Center Oncological Hadrontherapy (CNAO). accuracy...
Particle therapy (PT) has shown positive therapeutic results in local control of locally advanced pancreatic lesions. PT effectiveness is highly influenced by target localization accuracy both space, since the pancreas located proximity to radiosensitive vital organs, and time as it subject substantial breathing-related motion. The purpose this preliminary study was quantify range motion under typical treatment conditions. Three common immobilization devices (vacuum cushion, thermoplastic...
Purpose: External beam radiotherapy currently represents an important therapeutic strategy for the treatment of intraocular tumors. Accurate target localization and efficient compensation involuntary eye movements are crucial to avoid deviations in dose distribution with respect plan. This paper describes tracking system (ETS) based on noninvasive infrared video imaging. The was designed capturing tridimensional (3D) ocular motion provides on‐line estimation lesions position a priori...
Background/Objectives: Primary gynecological melanomas are rare malignancies with lower survival rates compared to cutaneous melanomas. Both preclinical and clinical data support the evidence that mucosal photon-radioresistant but responsive carbon ion radiotherapy (CIRT). The aim of this study is assess, in a real-world cohort, effectiveness tolerability radical CIRT patients inoperable melanoma. Methods: This aimed assess safety setting. We defined as primary endpoints objective response...
Purpose To evaluate a method for generating virtual four‐dimensional computed tomography (4DCT) from magnetic resonance imaging (4DMRI) data in carbon ion radiotherapy with pencil beam scanning abdominal tumors. Methods Deformable image registration is used to: (a) register each respiratory phase of the 4DMRI to end‐exhale MRI; (b) reference CT MRI volume; (c) generate 4DCT by warping registered according obtained deformation fields. A respiratory‐gated treatment plan optimized on planning...
Abstract Background Quantitative imaging such as Diffusion‐Weighted MRI (DW‐MRI) can be exploited to non‐invasively derive patient‐specific tumor microstructure information for characterization and local recurrence risk prediction in radiotherapy. Purpose To characterize according proliferative capacity predict through microstructural markers derived from pre‐treatment conventional DW‐MRI, skull‐base chordoma (SBC) patients treated with proton (PT) carbon ion (CIRT) Methods Forty‐eight...
The synergy between in-room imaging and optical tracking, in co-operation with highly accurate robotic patient handling represents a concept for patient-set-up which has been implemented at CNAO (Centro Nazionale di Adroterapia Oncologica). In-room is based on double oblique X-ray projection system; tracking consists of the detection position spherical markers placed directly patient's skin or immobilization devices. These are used as external fiducials during positioning dose delivery. This...
Abstract Purpose To define an optimal set of b ‐values for accurate derivation diffusion MRI parameters in the brain with segmented Intravoxel Incoherent Motion (IVIM) model. Methods Simulations signals were performed to targeting different perfusion regimes, by relying on optimization procedure which minimizes total relative error estimated IVIM computed a fitting procedure. Then, was acquired vivo healthy subjects and skull base chordoma patients compare optimized protocol clinical one....
In this study, we investigate the use of magnetic resonance imaging (MRI) for clinical evaluation gating treatment robustness in carbon-ion radiotherapy (CIRT) pancreatic cancer. Indeed, MRI allows radiation-free repeated scans and fast dynamic sequences time-resolved (TR) (cine-MRI), providing information on inter- intra-fraction cycle-to-cycle variations respiratory motion. can therefore support planning verification, overcoming limitations current standard, that is, four-dimensional...
Accurate patient positioning is crucial in particle therapy due to the geometrical selectivity of particles. We report and discuss National Center for Oncological Hadrontherapy (CNAO) experience accuracy stability achieved with solid thermoplastic masks fixed on index base plates assessed by daily orthogonal X-ray imaging.Positioning data were retrospectively collected (between 2012 2018) grouped according treated anatomical site. 19696 fractions 1325 patients evaluated.The study was...