A5007088899- Contact Dermatitis and Allergies
- Occupational exposure and asthma
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Skin Protection and Aging
- Carcinogens and Genotoxicity Assessment
- Immune Response and Inflammation
- Asthma and respiratory diseases
- Chemical Reactions and Isotopes
- Advancements in Transdermal Drug Delivery
- Immunotoxicology and immune responses
- Animal testing and alternatives
- Inhalation and Respiratory Drug Delivery
- Immunotherapy and Immune Responses
- Antimicrobial agents and applications
- Olfactory and Sensory Function Studies
- Effects and risks of endocrine disrupting chemicals
- Inflammatory mediators and NSAID effects
- Glutathione Transferases and Polymorphisms
- Pesticide Exposure and Toxicity
- Genomics, phytochemicals, and oxidative stress
- Air Quality and Health Impacts
- Phytochemistry and biological activity of medicinal plants
- Retinoids in leukemia and cellular processes
- Polyamine Metabolism and Applications
Universität Trier
2015-2025
Medical University of Graz
2022
Kao Corporation (Germany)
2022
Trier University of Applied Sciences
2008-2015
RWTH Aachen University
1998-2010
Universitätsklinikum Aachen
2001-2005
University Medical Centre Mannheim
2005
Heidelberg University
2005
University Hospital Heidelberg
2005
University of Miami
2005
Cancer risk from exposure to tobacco smoke varies widely person person, depending in part on the status of particular genes and acquired susceptibilities. Certain determine how cells activate detoxify carcinogens. Activated carcinogen metabolites may bind DNA form adducts (e.g., 7-methyl-2'-deoxyguanosine-3'-monophosphate [7-methyl-dGMP] polycyclic aromatic hydrocarbons-dGMP [PAHs-dGMP]), many which can induce genetic mutations. Thus, if individuals have an increased capacity carcinogens,...
Exposure to environmental tobacco smoke (ETS) is considered be a major lung cancer risk factor for never smokers. We investigated the hypothesis that never-smoking women who are exposed ETS and develop genetically susceptible population.Archival tumor tissues were analyzed from 106 enrolled in case-control study of (and other personal factors) risk. germline polymorphisms genes have been associated with susceptibility whose products activate (cytochrome P450 1A1 [CYP1A1]) detoxify...
Exposure to fine and ultra-fine ambient particles is still a problem of concern in many industrialised parts the world intensified use nanotechnology may further increase exposure small particles. Complex vitro coculture systems be valuable tools study particle-induced processes extrapolate effects on lung. A system consisting four different human cell lines which mimics response alveolar surface was developed native aerosol (Vitrocell™ chamber). The composed an type-II line (A549),...
During the last 250 years, level of exposure to combustion-derived particles raised dramatically in western countries, leading increased particle loads ambient air. Among environmental particles, diesel exhaust particulate matter (DEPM) plays a special role because its omnipresence and reported effects on human health. recent possible link between air pollution progression atherosclerosis is recognized. A central effect DEPM their impact endothelium, especially alveolar barrier. In present...
Skin is the major target of allergic reactions to paraphenylenediamine (PPD). Such small molecules require activation become immunogenic. The balance between and/or detoxification processes critical for immunogenic potentials compounds. Therefore, we investigated N-acetylation (NAT) capacities human skin PPD gain a better understanding its mechanisms action. acetylated monoacetyl-PPD (MAPPD), which in turn N,N'-diacetyl-PPD (DAPPD). This was found using cytosolic fractions from (n = 9) and...
Understanding the mechanistic aspects involved in sensitization by chemicals will help to develop relevant preventive strategies. Many potential sensitizers are not directly immunogenic but require activation outside or inside skin nonenzymatic oxidation (prehaptens) metabolic transformation (prohaptens) prior being able induce an immune response. This necessary step has yet been actively integrated into a cell line–based prediction approach. We cocultured HaCaT keratinocytes with THP-1 as...
Abstract While activation of the aryl hydrocarbon receptor (AhR) by exogenous ligands is well investigated, its physiological function less understood. By extending research in AhR biology, evidence appeared that generally plays an important role cell physiology. In keratinocytes, little known about endogenous functions AhR. order to expand this knowledge, we analyzed impact knockdown on cycle progression HaCaT cells and showed proliferation siAhR was significantly decreased. line with...
Significant progress has been made in the development and validation of non-animal test methods for skin sensitization assessment. At present, three four key events Adverse Outcome Pathway (AOP) are assessable by OECD-accepted vitro methods. The fourth event describes immunological response draining lymph node where activated dendritic cells present major histocompatibility complex-bound chemically modified peptides to naive T cells, thereby priming proliferation antigen-specific cells....
Despite a positive patch test reaction to para-phenylenediamine (PPD) and/or toluene-2,5-diamine (PTD), many people attempt continue dyeing their hair with products containing PPD or its derivatives.Investigation of elicitation reactions among PPD/PTD-allergic individuals dye the less sensitizing derivative 2-methoxymethyl (ME)-PPD.Elicitation were studied in 43 by 45-min pretest an ME-PPD-containing on forearm. Upon negative result this was followed exposure subsequent colour...
The naturally-occurring anthraquinones (AQs), alizarin (1,2-dihydroxyanthraquinone) and lucidin (1,3-dihydroxy-2-hydroxymethylanthraquinone), were incubated with DNA in the presence of S9 mix. isolated was analysed by 32P-postlabelling for aromatic adducts. Only formed up to five different adducts range from 0.995 3.05 adducts/10(8) nucleotides. Lucidin also polynucleotides poly[d(A-T)] polydG*polydC Analysis revealed a similar adduct pattern that obtained lucidin-modified DNA. Alizarin,...
Background: Para ‐phenylenediamine (PPD) and related chemicals are common contact sensitizers, frequently causing allergic dermatitis (ACD). The cytokine tumor necrosis factor‐alpha (TNF‐α) plays a key role in sensitization. Methods: In this case–control study, we evaluated the distribution of variations regulatory region gene for TNF‐α ( TNFA‐308 G/A ) 181 Caucasian individuals with history ACD sensitization to PPD 161 no PPD. Results: frequency GA or AA TNFA genotypes was significantly...