A5001709140- Tuberculosis Research and Epidemiology
- Health and Medical Education
- Public Health and Environmental Issues
- Public Health and Social Inequalities
- Pneumonia and Respiratory Infections
- Health Systems, Economic Evaluations, Quality of Life
- Pneumocystis jirovecii pneumonia detection and treatment
- Health and Medical Research Impacts
- Mycobacterium research and diagnosis
- Electronic Health Records Systems
- Antibiotic Use and Resistance
- Ethics and bioethics in healthcare
- Mosquito-borne diseases and control
- E-Learning and Knowledge Management
- Ethics in Clinical Research
- Biosimilars and Bioanalytical Methods
- Viral Infections and Vectors
- Public Policy and Governance
- Historical and Modern Theater Studies
- Antibiotics Pharmacokinetics and Efficacy
- Infectious Diseases and Tuberculosis
- HIV/AIDS oral health manifestations
- Biomedical Text Mining and Ontologies
- Aging, Health, and Disability
- Infection Control in Healthcare
National University of San Marcos
2011-2024
Ministerio de Salud
2022
Instituto Nacional de Salud
2007-2021
Medico
2012-2021
National Institute of Quality
2012-2017
Centro Nacional de Epidemiología
2016
Departamento de Epidemiología
2016
Direccion General de Epidemiologia
2016
Dirección Regional de Salud del Callao
2015
Ministerio de Salud
2014
Background. Increasing access to drugs for the treatment of multidrug-resistant (MDR) tuberculosis is crucial but could lead increasing resistance these same drugs. In 2000, international Green Light Committee (GLC) initiative began increase while attempting prevent acquired resistance.
Abstract Background. Resistance to second-line drugs develops during treatment of multidrug-resistant (MDR) tuberculosis, but the impact on outcome has not been determined. Methods. Patients with MDR tuberculosis starting drug were enrolled in a prospective cohort study. Sputum cultures analyzed at central reference laboratory. We compared subjects successful and poor outcomes terms (1) initial acquired resistance fluoroquinolones injectable (SLIs) (2) regimens. Results. Of 1244 patients 973...
Background Dengue is one of the most aggressively expanding mosquito-transmitted viruses. The human burden approaches 400 million infections annually. Complex transmission dynamics pose challenges for predicting location, timing, and magnitude risk; thus, models are needed to guide prevention strategies policy development locally globally. Weather regulates transmission-potential via its effects on vector dynamics. An important gap in understanding risk roadblock model an empirical...
Diabetes is a risk factor for active tuberculosis (TB). Data are limited regarding the association between diabetes and TB drug resistance treatment outcomes. We examined characteristics of patients with without in Peruvian cohort at high drug-resistant TB. Among (TB-DM), we studied clinical/management outcomes.During 2005-2008, adults suspected respiratory symptoms Lima, Peru, who received rapid susceptibility testing (DST), were prospectively enrolled followed during treatment. Bivariate...
Background For treating multidrug-resistant tuberculosis (MDR TB), the World Health Organization (WHO) recommends a regimen of at least four second-line drugs that are likely to be effective as well pyrazinamide. WHO guidelines indicate only marginal benefit for regimens based directly on drug susceptibility testing (DST) results. Recent evidence from isolated cohorts suggests containing more may beneficial, and DST results predictive effectiveness. The objective our study was gain insight...
Abstract Background Multi-drug resistant tuberculosis patients in resource-poor settings experience large delays starting appropriate treatment and may not be monitored appropriately due to an overburdened laboratory system, communication of results, missing or error-prone data. The objective this paper is describe electronic information system implemented alleviate these problems its expanding use by the Peruvian public sector, as well examine broader issues implementing such systems...
Background Lost, delayed or incorrect laboratory results are associated with delays in initiating treatment. Delays treatment for Multi-Drug Resistant Tuberculosis (MDR-TB) can worsen patient outcomes and increase transmission. The objective of this study was to evaluate the impact a information system reducing time MDR-TB patients culture convert (stop transmitting). Methods Setting: 78 primary Health Centers (HCs) Lima, Peru. Participants lived within catchment area participating HCs had...
El Perú realizó varios esfuerzos por identificar prioridades nacionales de investigación en salud desde 1974 mediante procesos históricamente planificados con base opiniones expertos, escaso impacto. Se decidió generar cambio la gestión para revertir las debilidades los anteriores, aplicando una metodología enfoque participativo y descentralista. Para establecer regionales enfocadas problemas sanitarios del país promover el compromiso participación actores clave, Instituto Nacional Salud...
Over the past 10 years, Peruvian National Tuberculosis (TB) Program, Reference Laboratory (NRL), Socios en Salud, and US partners have worked to strengthen national TB laboratory network support treatment of multidrug-resistant TB. We review key lessons this experience. The preparation phase involved establishing criteria for drug susceptibility testing (DST), selecting appropriate DST methods, projecting quantity culture ensure adequate supplies, creating biosafe facilities DST, training...
expresado la necesidad de mapear prevalencia las parasitosis en América Latina y el Caribe. En Perú no existen estudios que hayan medido dicha patología. Objetivos. Determinar frecuencia general por tipo helmintos año 2017 tendencia los últimos 8 años previos, a nivel nacional departamento. Métodos. Análisis base datos secundaria (Sistema Información Salud: HIS) del 2010 2017, contiene registro atenciones establecimientos salud Ministerio Salud. Para análisis tendencias se utilizó modelos...
Abstract The Peruvian National Tuberculosis Control Program issued guidelines in 2006 specifying criteria for culture and drug-susceptibility testing (DST), including district-level rapid DST. All patients referred DST 2 districts of Lima, Peru, during January 2005–November 2008 were monitored prospectively. Of 1,846 patients, 1,241 (67.2%) had complete results isoniazid rifampin; 419 (33.8%) multidrug-resistant (MDR) TB at the time referral. Among with new smear-positive TB, household...
Programmatic implementation of decentralized rapid drug susceptibility testing (DST) in Lima, Peru.Pre-post analysis compared time to diagnosis, treatment outcome and survival among patients tested with direct nitrate reductase assay (NRA) vs. indirect conventional methods.From 2005 2009, we prospectively followed all referred for DST before (control) after (intervention) NRA implementation. Among those DST, was used smear-positive samples no prior history multidrug resistance or...
El objetivo de este artículo es presentar el estado del Sistema Nacional Investigación en Salud Perú (SNIS), las lecciones aprendidas proceso construcción, oportunidades mejora y los retos. Se hace una descripción funciones SNIS peruano, con relación a la gobernanza, marco legal, priorización investigación, financiamiento, creación sostenibilidad recursos producción utilización investigación. describe que se ejerce gobernanza cuenta regulaciones, política prioridades estas últimas...
Abstract Data from a large multicenter observational study of patients with multidrug-resistant tuberculosis (MDR TB) were analyzed to simulate the possible use 2 new approaches treatment MDR TB: short (9-month) regimen and bedaquiline-containing regimen. Of 1,254 patients, 952 (75.9%) had no resistance fluoroquinolones second-line injectable drugs thus would qualify as candidates for 9-month regimen; 302 (24.1%) fluoroquinolone or drug in accordance published guidelines. Among regimen,...
La resistencia a los carbapenémicos es un problema de salud pública. Este estudio presenta la identificación enzimas carbapenemasas en Enterobacteriaceae, Pseudomonas spp. y Acinetobacter presentes cepas 30 instituciones prestadoras servicios del Perú como parte proceso control calidad diagnósticos. confirmación fenotípica e enzimática se realizó utilizando prueba Blue CARBA sinergia con discos ácido fenilborónico etilendiaminotetraacético/ mercaptoacético sodio. Se identificaron 185...
Objectives. To describe the characteristics of tuberculosis epidemiology in Peruvian health workers. Materials and methods. A descriptive study was performed. It included all workers with listed national epidemiological surveillance system Ministry Health, during 2013, 2014, 2015. Results. total 755 cases were reported: 60% worked hospitals, 28% primary-care facilities, 12% private facilities. In 57% cases, they facilities Lima Metropolitan area Callao. The average age 38 years (ranging from...
Objetivos. Describir las principales características de los ensayos clínicos (EC) autorizados en el Perú desde 1995 a agosto 2012. Materiales y métodos. Se realizó un estudio transversal, que se revisaron todos expedientes protocolos EC presentados para su evaluación posible aprobación al INS, cuyos datos forman parte del Registro Peruano EC. análisis descriptivo estados EC, fase estudio, especialidad, otras afines ellos. Resultados. encontraron 1475 cuales 1255 (85,1%) fueron autorizados....
The Potos flavus is a nocturnal mammal that lives in neotropical forests from Central America to South America. A study of four cases rabies was conducted; these occurred April 2012 the Madre de Dios region Peru and were collected as part epidemiological surveillance. analysis performed regional reference laboratory determined presence virus antigen three brain tissue samples. Results verified Laboratory Viral Zoonoses Peruvian National Institute Health by direct immunofluorescence....
Objectives. To identify factors behind a community’s reluctance to dengue vector control efforts in three districts of the Piura region Peru. Materials and methods. Fieldwork was conducted May 2015 Mori, Rinconada, Llicuar, Sullana on northern coast Qualitative research methods were employed understand varying perspectives individuals involved issue. Techniques such as interviewing observation used. Interviews included open-ended, in-depth questions. Individual interviews, focus groups, home...