A5101461216- Bacterial Identification and Susceptibility Testing
- Sepsis Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Chemotherapy-induced organ toxicity mitigation
- Asian Culture and Media Studies
- Spinal Cord Injury Research
- Lanthanide and Transition Metal Complexes
- Gut microbiota and health
- Hemodynamic Monitoring and Therapy
- Acute Kidney Injury Research
- Biosensors and Analytical Detection
- Heart Rate Variability and Autonomic Control
- Nosocomial Infections in ICU
- Vagus Nerve Stimulation Research
- Cardiac Arrest and Resuscitation
- Pancreatitis Pathology and Treatment
- Education and Learning Interventions
- Neurological Complications and Syndromes
- Body Composition Measurement Techniques
- Inflammation biomarkers and pathways
- Nerve Injury and Rehabilitation
- Ultrasound in Clinical Applications
- Liver Disease Diagnosis and Treatment
- Research studies in Vietnam
- Urban and spatial planning
Seoul National University Bundang Hospital
2018-2025
Samsung Medical Center
2024-2025
Sungkyunkwan University
2024-2025
Ulsan National Institute of Science and Technology
2021
We aimed to assess whether patients with rheumatoid arthritis (RA) have a higher risk of developing acute and chronic pancreatitis compared individuals without RA. identified 54,910 RA between 2010 2017. After exclusion, they were matched in 1:3 ratio based on age gender control population Cox regression analyses performed estimate hazard ratio. During median follow-up 5.5 years, 0.18% the 0.14% developed pancreatitis. The was cohort (adjusted [aHR] 1.33; 95% confidence interval [CI]...
Despite the accumulation of cisplatin in proximal tubules, direct visualization surrounding peritubular microcirculation, including its alteration cisplatin-induced acute kidney injury (AKI), is lacking. Here, using fluorescence and cellular angiography through video-rate high-resolution intravital microscopy, progressive disturbance microcirculation AKI mice was demonstrated. Fluorescence revealed increasing perfusion defects, with a stepwise rise time to peak (TTP), originating from...
The current diagnosis of bacteremia mainly relies on blood culture, which is inadequate for the rapid and quantitative determination most bacteria in blood. Here, a quantitative, multiplex, microfluidic fluorescence situ hybridization method (μFISH) developed, enables early (3-h) without need prior culture. This novel technology employs mannose-binding lectin-coated magnetic nanoparticles, effectively opsonize broad range pathogens, magnetically sequestering them device. Therein, μFISH...
Recent studies have suggested the existence of a blood microbiome in healthy host. However, changes upon bloodstream infection are not known. Here, we analyzed dynamics porcine model polymicrobial bacteremia induced by fecal peritonitis. Surprisingly, detected bacterial populations even before infection, and these were maintained over time. The native was notably taxonomically different from that used to induce peritonitis, reflecting microbial tropism for blood. Although population...
Cerebral mitochondrial dysfunction during post–cardiac arrest syndrome (PCAS) remains unclear, resulting in a lack of therapeutic options that protect against cerebral ischemia–reperfusion injury. We aimed to assess the hippocampus after cardiac and whether vagus nerve stimulation (VNS) can improve neurological outcomes. In an asphyxial model, male Sprague–Dawley rats were assigned isolation (CA) or VNS (CA + VNS) group. Cardiopulmonary resuscitation was performed 450 s pulseless electrical...
Proper selection of susceptible antibiotics in drug-resistant bacteria is critical to treat bloodstream infection. Although biomarkers that guide antibiotic therapy have been extensively evaluated, little known about host targeting vivo susceptibility. Therefore, we aimed evaluate the trends hemodynamics and a porcine bacteremia model treated with insusceptible compared those models. Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E. coli, 5.0 * 10^9 CFU) was intravenously...
Despite the accumulation of cisplatin in proximal tubules, direct visualization surrounding peritubular microcirculation, including its alteration cisplatin-induced acute kidney injury (AKI), is lacking. Here, using fluorescence and cellular angiography through video-rate high-resolution intravital microscopy, we demonstrated disturbance microcirculation AKI mice. Fluorescence revealed that perfusion defects increased during progression were initiated from capillary S1segments. Temporal...
Purpose: Proper antibiotic administration is crucial for sepsis management. Given the escalating incidence of antimicrobial resistance, there a pressing need indicators susceptibility with short turnaround times. This study aimed to investigate potential soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as an early biomarker in vivo patients sepsis. Patients and Methods: We conducted retrospective analysis plasma samples from enrolled pre-established designed prognostic...
Objectives: Estimating the risk of diabetes mellitus (DM) is important for proper management patients with spinal cord injury (SCI). We investigated short-term and long-term risks DM among SCI, according to presence or severity post-SCI disability level injury. Methods: conducted a retrospective cohort study using Korean National Health Insurance Service (2010–2018) database. After matching by age sex, 6129 SCI 22,979 controls were included. The primary outcome was incident DM, evaluated...
Abstract Fluid resuscitation is crucial in the initial management of sepsis; however, little known about serial changes and overall distribution fluids administered into body. To identify feasibility longitudinal bioelectrical impedance analysis during fluid treatment, a preclinical porcine model Escherichia coli- induced sepsis was used. After induction, pigs were treated with vasopressors monitored for up to 12 h after bacterial infusion or until death. Bipolar electrodes attached left...
Immunoreactive dynamics of tumor-infiltrating lymphocytes (TILs) within the tumor microenvironment in breast cancer are not well understood. This study aimed to investigate spatiotemporal cellular TILs models. Breast cells were implanted into dorsal skinfold chamber BALB/c nude mice, and T adoptively transferred. Longitudinal intravital imaging was performed, assessed. In 4T1 model, progressively exhibited increased motility, their motility inside significantly higher than that outside...
Abstract Mitigating sepsis‐induced severe organ dysfunction with magnetic nanoparticles has shown remarkable advances in extracorporeal blood treatment. Nevertheless, treating large septic animals remains challenging due to insufficient separation at rapid flow rates (>6 L h −1 ) and limited incubation time an circuit. Herein, superparamagnetic nanoclusters (SPNCs) coated red cell (RBC) membranes are developed, which promptly capture magnetically separate a wide range of pathogens high...
본고는 최근에 정리된 고구려사 관련 연구논저 목록에 음악과 무용 방면의 연구성과가 제대로 반영되지 않아 이를 보완하려는 측면에서 지금까지 연구성과를 보충하였고, 남한과 북한의 연구경향을 파악하여 앞으로 요청되는 과제를 모색해 보고자 마련하였다. 경우 약 37년 동안 9편의 연구물과 3명의 연구자가 참여한 데 비하면 남한의 연구는 56년 연구물이 48편에 이르며, 연구자는 40명이므로 여러 활발했다고 볼 수 있다. 그러나 벽화에 나타난 악기와 연주형태 및 무용을 총체적으로 정리한 점으로 봤을 때는 소량이긴 하나 알찬 점이 지금까지의 연구 경향을 바탕으로 앞으로의 제시하면, 첫째는 고구려 고분벽화에 있어서 음악학계에서 주로 관심가진 문제는 주악상의 악기가 무엇인가? 또는 그 악기의 명칭은 무엇이 바람직한가에 집중되었다고 1차적으로 악기 판독이 가장 기초적이고 중요한 사안이지만, 그려진 연주의 의미를 찾는 연구도 병행되어야 한다고 생각한다. 따라서 주악상은 고구려인의 종교와...
이 글은 ‘삼현육각(三絃六角)’이란 용어에서 ‘삼현(三絃)’의 의미를 찾고자 시작한 글이다. 삼현이란 용어는 고대 신라 때부터 사용되었고, 현재에도 사용하고 있는 장수(長壽) 낱말이다. 때 현악기 3종인 거문고·가야금·비파를 지칭하는 의미에서 비롯되었지만 오늘날 의미와 다르게 삼현영산·삼현장단·삼현타령·삼현삼죽·삼현굿거리·삼현풍류 등의 용어를 있다. 이런 경우 삼현은 과연 어떤 지녔는가에 대한 의문을 해결하기 위해 글을 시도하였다. 먼저 삼현이 현악기를 사례를 검토한 결과 모두 다섯 가지 의미가 있음을 밝혔다. 첫째는 신라시대 3종의 현악기인 총칭하는 의미다. 이것은 이미 학계에 널리 알려진 사실이다. 둘째, 중국 중 세 줄로 구성된 ‘삼현금(三絃琴)’을 지칭하며, 이것의 준말로 ‘삼현’이라 했다. 셋째, 금(琴)의 번째 현을 의미로도 사용되었다. 넷째, 일본의 3종 즉 비파(琵琶)와 쟁(箏) 그리고 화금(和琴)을 의미로 다섯째, 유구국(流球國)이나 일본에서 사용하는...
이 글은 현재 대취타에 사용하고 있는 악기 중에 ‘나각(螺角)’이란 악기의 명칭이 과연 바람직한 용어인지에 문제를 제기하여 올바른 용어 정립을 위해 시도한 글이다. 해결하기 문헌에 기록된 ‘나(螺)’와 ‘나각(螺角)’의 사례를 각각 검토하였다. 그 결과 ‘나(螺)’라는 명칭은 고려시대부터 사용하기 시작하였고, 조선 500년을 거쳐 근대 1902년까지 그림과 함께 기재된 주된 명칭임을 확인하였다. 특히 1493년에 편찬된 『악학궤범』이나 후기에 『종묘의궤』와 잔치 관련 여러 의궤 속에 ‘나(螺)’였다. 그러므로 ‘나(螺)’란 1123년부터 근대까지 약 800년간 사용된 용어임을 한편, 중기에 ‘각(角)’을 교대로 분 데서 비롯된 용어다. 즉 ‘나각교취(螺角交吹)’에서 명칭이다. 그런데 18세기 정조 때부터는 기존의 명칭인 생성된 혼재되기 시작했다. 같은 문헌 내에서 두 용어를 혼용한 사례는 100년 정도 지속되었다. 그러나 이것이 일제 강점기를 통과하면서 고착화된 사실을...