Gut microbiota dysbiosis has been implicated as a vital element in the development or exacerbation of mental disorders, such major depressive disorder (MDD). Based on current interest gut-brain axis, we investigate effects chlorogenic acid (CGA) gut rat model MDD. Depression was induced by adrenocorticotropic hormone (ACTH, 100 μg per rat) male Wistar rats, which were intervened with using saline CGA (500 mg kg-1). Behavioral changes and serum parameters assessed fecal samples analyzed 16S...

Paeoniflorin, the main active component of peony plant, exerts various pharmacological effects. Recently, research on effect paeoniflorin nervous system has gained more attention. The aim present study was to determine whether a protective that improves Alzheimer's disease (AD) via inflammation and apoptosis in cerebral cortex transgenic mouse model AD. Transgenic mice were used construct AD treated with paeoniflorin. Morris water maze test analyze cognitive function mice. protein expression...

There is no reliable causal evidence for the effect of statins on diabetic nephropathy (DN) and retinopathy (DR), results previous observational studies are contradictory. Genetic variants linked to low-density lipoprotein cholesterol (LDL-C) from a UK biobank genome-wide association study located within 100kb window around HMGCR were used proxy statins, comparing with PCSK9 inhibitors (control). DN DR summary statistics obtained FinnGen study. Secondary MR analyses NHANES cross-sectional...

Resveratrol has also been approved for use in enhancing plant disease resistance and reducing pesticide use. A number of studies have shown that the crops treated with resveratrol is markedly improved. The aim present study was to examine protective effect against alcohol‑induced neurodegeneration occurred its association AMP‑activated protein kinase (AMPK)/sirtuin 1 (SIRT1)/p38 rats humans. ELISA, caspase‑3 activity western blot analyses were employed study. Sprague‑Dawley human...

To investigate the changes in cortical thickness of region interest (ROI) and plasma Aβ40, Aβ42, phosphorylated Tau (P-Tau) concentrations patients with Alzheimer's disease (AD) amnestic mild cognitive impairment (aMCI) as progressed surface-based morphometry (SBM), to analyze correlation between ROI measured indexes neuropsychological scales, explore clinical value combined P-Tau early recognition diagnosis AD.This study enrolled 33 AD, 48 aMCI, healthy controls (normal control, NC)....

Recent evidence shows that excess nicotinamide can cause epigenetic changes in developing rats. The aim of the present study was to investigate effects maternal supplementation on fetus. Female rats were randomised into four groups fed a standard chow diet (control group) or diets supplemented with 1 g/kg (low-dose group), 4 (high-dose plus 2 betaine (betaine for 14–16 d before mating and throughout study. Fetal tissue samples collected 20th day pregnancy. Compared control group, high-dose...

Volume reduction and structural abnormality is the most replicated finding in neuroimaging studies of Alzheimer's disease (AD). Amnestic mild cognitive impairment (aMCI) early stage AD development. Thus, it necessary to investigate link between atrophy regions interest (ROIs) medial temporal lobe, variation trend ROI densities volumes among patients with impairment, distribution characteristics ROIs aMCI group, (AD) normal control (NC) group.30 aMCI, 16 AD, 30 NC are recruited; magnetic...

Abstract Background and purpose Parkinson's disease (PD) is a severe neurodegenerative with high morbidity in the elderly population. 6‐OHDA‐induced cell senescence reported to be involved pathogenesis of PD. Ramelteon an oral hypnotic agent that specifically targets receptors suprachiasmatic nucleus human hypothalamus. Here, investigation made see whether possesses beneficial effect against cellular SH‐SY5Y neuronal cells. Methods The release LDH was detected assess cytotoxicity flow...

Abstract Backgroud: A large amount of research has shown that spinal cord injury causes bone loss and increases fracture risk, while injuries caused by fractures their underlying molecular mechanisms still need further investigation. Methods To investigate the specific changes in after fractures, we obtained L4-L5 segments from same side SD rats with tibial at 0, 3, 7, 14, 28 days fracture. Gene Ontology (GO) enrichment analysis, KEGG pathway Ingenuity Pathway Analysis(IPA) were used to...

Activation of the nerve growth factor (NGF) signaling pathway is a potential method treatment for retinal ganglion cell (RGC) loss due to traumatic optic neuropathy (TON). The present study aimed explore biological effects injecting Astragalus membranaceus ( A. mem ) on RGCs in an experimental TON model. Adult male Wistar rats were randomly divided into three groups: sham‐operated (SL), model (ML), and injection (AL). left eyes considered eyes, right served as controls. AL received daily...

The coordination of motor function in the spinal cord depends on selective connections between distinct classes neurons and their target muscles. However, knowledge regarding anatomical superficial limb skeletal muscles that innervate them is limited. In this study, with a combination multiple retrograde tracing method 3DISCO clearing, we explored spatial distribution different neuron pools targeting specific forelimbs or hindlimbs mouse cords, which were dominated by radial, median, ulnar,...

Abstract JOURNAL/nrgr/04.03/01300535-202407000-00036/figure1/v/2023-11-20T171125Z/r/image-tiff Coordinated contraction of skeletal muscles relies on selective connections between the and multiple classes spinal motoneurons. However, current research spatial location motoneurons innervating different is limited. In this study, we investigated distribution relative position that control deep mouse hindlimbs, which were innervated by obturator nerve, femoral inferior gluteal peroneal tibial...

Bone marrow stromal cells (BMSCs) have an important application prospect in the field of cell therapy for various neurodegenerative diseases, and inducing factors that regulate BMSC differentiation are proposed as a promising therapeutic strategy. In this study, we explored effect glial cell-derived neurotrophic factor (GDNF) on course differentiation.BMSCs were isolated from rat bone induced by GDNF. The effects GDNF viability proliferation verified counting kit-8, MTT, bromodeoxyuridine,...

Observing the dynamic progress of brain in response to peripheral nerve stimulation as a whole is basis for deeper understanding overall function; however, it remains great challenge. In this work, novel mini-invasive orthogonal recording method developed observe evoked cortex potential (ECP) rat brain. A typical ECP atlas with recognizable waveforms corresponding median, ulnar, and radial trunks subdivided branches acquired. Reproducible exciting temporal–spatial obtained visualized first...