A5043124354- Particle accelerators and beam dynamics
- Particle Accelerators and Free-Electron Lasers
- Superconducting Materials and Applications
- Particle Detector Development and Performance
- Nuclear Physics and Applications
- Muon and positron interactions and applications
- Immune Cell Function and Interaction
- Neutrino Physics Research
- T-cell and B-cell Immunology
- Particle physics theoretical and experimental studies
- Magnetic confinement fusion research
- Gyrotron and Vacuum Electronics Research
- Plasma Diagnostics and Applications
- Astrophysics and Cosmic Phenomena
- Immunotherapy and Immune Responses
- Aldose Reductase and Taurine
- Immune Response and Inflammation
- Electromagnetic Simulation and Numerical Methods
- Estrogen and related hormone effects
- Wnt/β-catenin signaling in development and cancer
- Monoclonal and Polyclonal Antibodies Research
- Atomic and Molecular Physics
- Spacecraft and Cryogenic Technologies
- Radiation Detection and Scintillator Technologies
- Malaria Research and Control
European Spallation Source
2011-2020
Fermi National Accelerator Laboratory
2003-2014
University of Skövde
2005-2013
Stockholm University
2002-2012
Fraunhofer Chalmers Research Centre for Industrial Mathematics
2010
UNSW Sydney
2005-2007
Fermi Research Alliance
2007
European Organization for Nuclear Research
2000-2003
Uppsala University
1996
PD-1, a receptor expressed by T cells, B and monocytes, is potent regulator of immune responses promising therapeutic target. The structure interactions human PD-1 are, however, incompletely characterized. We present the solution nuclear magnetic resonance (NMR)-based extracellular region detailed analyses its with ligands, PD-L1 PD-L2. has typical immunoglobulin superfamily topology but differs at edge GFCC' sheet, which flexible completely lacks C" strand. Changes in backbone NMR signals...
The Pseudomonas aeruginosa quorum-sensing molecule N-3-(oxododecanoyl)-L-homoserine lactone (OdDHL) has been reported to have immunomodulatory activity in several systems, although the mechanism of that remains be fully characterized. We demonstrate here, using a defined vitro model antigen responses by T-cell receptor (TCR)-transgenic mouse splenic CD4 T cells, effect OdDHL on activation and cytokine production is complete within 4 h or mitogen stimulation does not depend insertion cell...
It is now well documented that human embryonic stem cells (hESCs) can differentiate into functional cardiomyocytes. These constitute a promising source of material for use in drug development, toxicity testing, and regenerative medicine. To assess their utility as replacement or complement to existing models, extensive phenotypic characterization the required. In present study, we used microarrays analyzed global transcription hESC-derived cardiomyocyte clusters (CMCs) determined...
The term beta-beam has been coined for the production of a pure beam electron neutrinos or their antiparticles through decay radioactive ions circulating in storage ring. This concept requires to be accelerated Lorentz gamma 150 6He and 60 18Ne. neutrino source itself consists ring this energy range, with long straight sections line experiment(s). Such does not exist at CERN today, nor high-intensity proton ions. Nevertheless, existing accelerator infrastructure could used as would still...
Understanding the component stoichiometry of T cell antigen receptor (TCR) triggering apparatus is essential for building realistic models signal initiation. Recent studies suggesting that TCR and other signaling-associated proteins are preclustered on resting cells relied measurements behavior membrane at interfaces with functionalized glass surfaces. Using fluorescence recovery after photobleaching, we show that, compared apical surface, mobility TCRs significantly reduced Jurkat...
We present a theoretical framework for simulating the synaptic accumulation of costimulatory molecules CD28, CTLA-4, B7-1, and B7-2, based on system mean-field, ordinary differential equations, rigorous biophysical expression data. The simulations show that binding affinity, stoichiometric properties, levels, and, in particular, competition effects all profoundly influence complex formation at cellular interfaces. B7-2 engages 33-fold more CD28 than CTLA-4 synapse contrast to which ligates...
The elimination of malaria in Zanzibar is highly dependent on sustained effective coverage bed-nets to avoid resurgence. Health Belief Model (HBM) framework was used explore the perceptions and bed-net use after a noticeable reduction incidence. Nineteen in-depth interviews were conducted with female male caretakers children under five North A district, Zanzibar. Deductive content analysis identify meaning units that condensed, coded assigned pre-determined elements HBM. Awareness among high...
An AC dipole is a magnet which produces sinusoidally oscillating field and excites coherent transverse beam oscillations in synchrotron. By observing this driven oscillation, the linear optical parameters can be directly measured at locations of position monitors. The induced by an will generate phase space ellipse differs from that free oscillations. If not properly accounted for, difference lead to misinterpretations actual parameters, for instance, 6% or more cases Tevatron, RHIC, LHC....
We explore an alternative strategy to determine the neutrino mass hierarchy by making use of possible future facilities at Fermilab. Here, we $CPT$-conjugate channels, exploiting a ${\ensuremath{\nu}}_{\ensuremath{\mu}}$ beam from NuMI beamline and ${\overline{\ensuremath{\nu}}}_{e}$ beta-beam experimental setup. Both experiments are performed approximately same $⟨E⟩/L$. present different accelerator scenarios for setup fluxes. This channel scenario can extract down...
The Neutrino Factory is a new concept for an accelerator that produces high-intensity, high-energy beam of electron and muon neutrinos – the ultimate tool neutrino oscillation studies only machine conceived up today could help detect CP violation leptons. basic production from decay muons. Due to their short lifetime, these muons have be accelerated very fast. Several techniques, like high-intenstiy proton linac, high-power targets, ionization cooling or recirculating linacs are required....
The Tevatron in Collider Run II (2001-present) is operating with six times more bunches and many higher beam intensities luminosities than I (1992-1995). Beam diagnostics were crucial for the machine start-up never-ending luminosity upgrade campaign. We present overall picture of development II, outline needs new instrumentation, several notable examples that led to performance improvements, discuss lessons future colliders.
Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide, but also common colonizer the upper respiratory tract. The emergence spread antibiotic resistant pneumococcal strains has threatened effective therapy. long-term effects measures aiming to limit are poorly understood. Computational modeling makes it possible conduct virtual experiments that impractical perform in real life thereby allows more full understanding epidemiology control efforts. We have developed...
The T cells scan the surface of antigen-presenting with their cell receptors (TCR) in order to find and respond specific peptide-major histocompatibility complexes (pMHC). Since mainly self-peptides are expressed on cells, must utilize sensible mechanisms quickly discriminate between self nonself-peptides. A range different models have been proposed account for this process. Due experimental inconsistency how altered peptides it has difficult validate competing models. Recent models, based...
A means for non-invasive measurement of transverse and longitudinal characteristics bunched beams in synchrotrons has been developed based on high sensitivity slotted waveguide pickups. The pickups allow bandwidths exceeding hundreds MHz while maintaining good beam characteristics. Wide bandwidth is essential to bunch-by-bunch measurements by a fast gate. Schottky detector system installed successfully commissioned the Fermilab Tevatron, Recycler CERN LHC synchrotrons. Measurement...
Th-cell development has been suggested to include selective mechanisms in which certain cytokines select either Th1 or Th2 cells proliferate and grow. The theory is based on the observation that secrete IL-4, a cytokine promotes development, whereas interferon-gamma (IFN-gamma) favours both positive negative influences have operate. In this study, we investigate role of autocrine secretion utilization IL-4 by address question whether an activated cell can be positively selected secreted from...
The LHC Schottky observation system is based on traveling wave type high sensitivity pickup structures operating at 4.8 GHz. choice of the structure and frequency driven by demanding impedance requirements, where very low required below 2 GHz, good selected band A sophisticated filtering triple down-mixing signal processing chain has been designed implemented in order to achieve specified 100 dB instantaneous dynamic range without switching. Detailed design aspects for complete systems test...