A5063811820- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Chronic Lymphocytic Leukemia Research
- Life Cycle Costing Analysis
- Memory and Neural Mechanisms
- Health, Environment, Cognitive Aging
- Mitochondrial Function and Pathology
- Mesenchymal stem cell research
- Neurotransmitter Receptor Influence on Behavior
- Organ Transplantation Techniques and Outcomes
- Reliability and Maintenance Optimization
- Reproductive System and Pregnancy
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
- Problem and Project Based Learning
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- Neuroscience and Neuropharmacology Research
- Lymphoma Diagnosis and Treatment
- Integrated Water Resources Management
- Innovative Teaching and Learning Methods
- Technical Engine Diagnostics and Monitoring
- Chronic Myeloid Leukemia Treatments
University of West Bohemia
2008-2023
A catalog of common, intermediate and well‐documented (CIWD) HLA‐A, ‐B, ‐C, ‐DRB1, ‐DRB3, ‐DRB4, ‐DRB5, ‐DQB1 ‐DPB1 alleles has been compiled from over 8 million individuals using data 20 unrelated hematopoietic stem cell volunteer donor registries. Individuals are divided into seven geographic/ancestral/ethnic groups summarized for each group the total population. P (two‐field) G assignments one four frequency categories: common (≥1 in 10 000), 100 (≥5 occurrences) or not‐CIWD. Overall 26%...
The guidelines for the implementation and reporting of HLA nomenclature World Marrow Donor Association have served as a reliable standard communication data in hematopoietic cell transplantation process. Wider use next-generation sequencing made special provision increasingly pertinent: how to communicate novel alleles. Novel alleles need be recognized by WHO Nomenclature Committee Factors system obtain official allele designations. Until then they handled according specific rules. Leaving...
NKG2D and its ligands, MICA MICB, are known as the key regulators of NK cells. cells first reconstituted after allogeneic hematopoietic stem cell transplantation (HSCT); therefore, it is crucial to understand their role in HSCT outcome. In presented study, we investigated single amino acid changes across exons 2-4 MICB genes, point mutations within gene, which defines type haploblock (HNK/LNK) donors (n = 124), well patients with acute myeloid leukemia 78). our cohort, found that graft from...
The new HLA ‐A*02: 395N allele differs from A*02:01:01 at one nucleotide position in the exon 2.
Killer-immunoglobulin-like receptors (KIRs) are critical natural killer (NK) cell regulators. The expression of KIRs is a dynamic process influenced by many factors. Their ligands-HLA(Human Leukocyte Antigen) class I molecules-are expressed on all nucleated cells that keep NK under control. In hematopoietic stem transplantation (HSCT), play an essential role in relapse protection. the presented pilot study, we characterized inhibitory KIRS (iKIRs), which protect against untoward lysis,...
Genetic and transcriptional heterogeneity of Chronic lymphocytic leukaemia (CLL) limits prevention disease progression. Longitudinal single-cell transcriptomics represents the state-of-the-art method to profile at diagnosis inform about evolution. Here, we apply RNA-seq a CLL case, sampled relapse, that was treated with FCR (Fludarabine, Cyclophosphamide, Rituximab) underwent dramatic decrease in CD19 expression during Computational analyses revealed major switch clones' dominance treatment....
Despite advances in immunochemotherapy CLL remains an incurable disease.. Allogeneic haematopoietic cell transplantation (HCT) has proven curative potential with ability to overcome adverse prognostic factors, however due its toxicity it is generally perceived as the last option. We performed retrospective study explore outcomes and possible determinants of survival unselected consecutive cohort 68 patients (median age 59 years) receiving reduced intensity HCT a part salvage therapy 2 Czech...
ACTA Press publishes numerous proceedings like technical publications, scientific publications for power and energy systems research papers international conferences in the general areas of engineering computer science.