A5043200974- Cervical Cancer and HPV Research
- Hepatitis B Virus Studies
- Molecular Biology Techniques and Applications
- Reproductive tract infections research
- RNA modifications and cancer
- Genital Health and Disease
- Cancer Genomics and Diagnostics
- Head and Neck Cancer Studies
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Viral-associated cancers and disorders
- Colorectal and Anal Carcinomas
- Global Cancer Incidence and Screening
Freie Universität Berlin
2020-2023
Charité - Universitätsmedizin Berlin
2020-2023
Humboldt-Universität zu Berlin
2020-2023
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2020
Abstract Background Cervical cancer is the fourth most common among women worldwide. Sub- Saharan Africa has a high incidence, prevalence and mortality due to shortage underutilization of screening facilities. This study aims assess knowledge attitude towards cervical its prevention, as well practice screening. Methods cross-sectional community- based was conducted in Butajira, Ethiopia February 2018. Systematic cluster randomized sampling used select households from which targeted age group...
In Ethiopia, cervical cancer is the second leading cause of morbidity and mortality from all cancers in women. Persistent infection with human papillomaviruses (HPV) plays a key role development intraepithelial neoplasia invasive cancer. To establish baseline data on population-based prevalence HPV genotype distribution, we investigated epidemiology among rural This study was conducted women aged 30-49 years Butajira, south-central Ethiopia. A total 893 samples were tested 1020 screened...
BackgroundTo date, no studies have successfully shown that a highly specific, blood-based tumour marker to detect clinically relevant HPV-induced disease could be used for screening, monitoring therapy response or early detection of recurrence.This study aims assess the clinical performance newly developed HPV16-L1 DRH1 epitope-specific serological assay.MethodsIn multi-centre sera 1486 patients (301 Head and Neck Squamous Cell Carcinoma (HNSCC) patients, 12 HIV+ anal cancer 80 HIV-positive...
Infections with human papillomaviruses (HPV) are sexually transmitted and can cause cancer. In Germany, vaccination against HPV is recommended for girls boys aged 9-17 years. We aimed to investigate DNA prevalence, genotype distribution vaccine effectiveness (VE) in women 20-25 years 10 after the introduction of Germany (2018-2019), compared these data an equally designed study from 2010-2012.Seventy six geographical clusters were randomly selected, followed by random selection 61 per...
Persistent infection with human papillomavirus (HPV) can lead to cervical cancer (CxCa). During the progression CxCa, expression of HPV oncogenes E6 and E7 is upregulated. In turn, cellular proteins such as p16INK4a are also modulated. The combined detection biomarkers indicative for dysplasia could be informative convey better specificity than current tests that cannot discriminate transient from dysplastic changes.The QuantiGeneTM 2.0 Plex Assay platform was chosen effective multiplexing...
<h3>Introduction/Background</h3> The use of self-sampling in cervical cancer (CxCa) screening increases the number participants and enables inclusion prior underscreened women rural areas. For PCR DNA-based testing is as sensitive physician-sampling. We compared self- physician-sampling for analysis by QuantiGene-Molecular-Profiling-Histology assay (QG-MPH) to detect grade dysplasia a triage setting. <h3>Methodology</h3> Women with an equivocal result were recruited sample (Cervex broom) was...
Background HNSCC has different etiology that influences therapy susceptibility. Infection with human papillomaviruses (HPV) or exposure to toxic substances can lead cellular transformation. HPV-positive tumors have a better prognosis. The knowledge of HPV association, expression oncogenes and related biomarkers may be important.
High-risk Human Papillomavirus (HPV) is the most important cause of cervical cancer. The highest burden disease seen in Low- and Low-Middle-Income Countries (LMIC). Several new HPV screening assays have been developed for high-risk (hr-HPV) testing. We compared performance adequacy three genotyping on samples from a population rural women south-central Ethiopia.
<h3>Introduction/Background</h3> In 2019, 47.7% of all eligible women in Germany participated cervical cancer screening. Since 2020 screening includes HPV/cytology co-testing from age 35 onwards. Self-sampling for HPV detection could reduce barriers and increase participation. <h3>Methodology</h3> This mixed-methods sub-study the FACTS-project aimed to focus on experiences affected potential use self-sampling Germany. All included FACTS project (n=696) were asked perform (Evalyn-Brush)...