A5102825867- Obstructive Sleep Apnea Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Inflammasome and immune disorders
- Respiratory Support and Mechanisms
- Adenosine and Purinergic Signaling
- Neuroscience of respiration and sleep
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Lymphatic System and Diseases
- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
- Thermal Regulation in Medicine
- Hematological disorders and diagnostics
- Liver Diseases and Immunity
- Apelin-related biomedical research
- Mesenchymal stem cell research
- Cardiovascular and exercise physiology
- Congenital heart defects research
- Pharmacological Receptor Mechanisms and Effects
- COVID-19 Impact on Reproduction
- Vascular Malformations and Hemangiomas
- Kawasaki Disease and Coronary Complications
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2020-2025
Hospital Universitario La Paz
2019-2024
Centre for Biomedical Network Research on Rare Diseases
2020-2024
Centro de Investigación Biomédica en Red
2023
Hospital La Paz Institute for Health Research
2021-2023
Respiratory Clinical Trials
2022
Spanish National Centre for Cardiovascular Research
2020
Hospital Universitario Puerta del Mar
2006
Abstract Background Hyperinflammation, hypercoagulation and endothelial injury are major findings in acute post-COVID-19. The SARS-CoV-2 S protein has been detected as an isolated element human tissues reservoirs is the main product of mRNA COVID-19 vaccines. We investigated whether alone triggers pro-inflammatory pro-coagulant responses primary cultures two cell types deeply affected by SARS-CoV-2, such monocytes cells. Methods In umbilical vein cells (HUVEC) monocytes, components NF-κB...
Rationale: As the mechanism that links obstructive sleep apnea (OSA) with regulation of inflammatory response is not well known, it important to understand inflammasome activation, mainly NLRP3 (nucleotide-binding oligomerization domain-like receptor 3). Objectives: To assess activity in patients severe OSA and identify its role systemic OSA. Methods: We analyzed as key components cascade, such adaptor molecule apoptosis-associated speck-like protein, caspase-1, Gasdermin D, IL-1β, IL-18,...
CD39/NTPDase1 has emerged as an important molecule that contributes to maintain inflammatory and coagulatory homeostasis. Various studies have hypothesized the possible role of CD39 in COVID-19 pathophysiology since no confirmatory data shed light this regard. Therefore, we aimed quantify expression on patients exploring its association with severity clinical parameters ICU admission, while unraveling purinergic signaling thromboinflammation patients. We selected a prospective cohort...
Abstract Background Understanding the enduring respiratory consequences of severe COVID-19 is crucial for comprehensive patient care. This study aims to evaluate impact post-COVID conditions on sequelae acute distress syndrome (ARDS). Methods We examined 88 survivors COVID-19-associated ARDS six months post-intensive care unit (ICU) discharge. Assessments included clinical and functional evaluation as well plasma biomarkers endothelial dysfunction, inflammation, viral response. Additionally,...
Background Intermittent hypoxaemia and obstructive sleep apnoea (OSA) have been linked to lung cancer through as yet unidentified pathophysiological mechanisms. This study evaluates the effect of OSA on serum levels biomarkers immunosurveillance, lymphangiogenesis intrinsic tumour cell aggressiveness in high-risk individuals screened for patients with established cancer. Methods Serum samples from participating a screening cohort (SAILS study) or newly diagnosed (SAIL were analysed. All...
Immunosurveillance is compromised in patients with obstructive sleep apnea (OSA) as reflected by overexpression of the programmed death cell receptor and its ligand (PD-1/PD-L1) coinhibitory axis. However, contributions intermittent hypoxia (IH) fragmentation (SF) are unclear. We therefore evaluated expression PD-1 PD-L1 on immune cells from mice subjected to IH or SF, human exposed IH, oxidative stress, both conditions. Six-week-old male C57BL/6J were either SF using previously established...
Severe COVID-19 disease leads to hypoxemia, inflammation and lymphopenia. Viral infection induces cellular stress causes the activation of innate immune response. The ubiquitin-proteasome system (UPS) is highly implicated in viral response regulation. main function proteasome protein degradation its active form, which recognises binds ubiquitylated proteins. Some subunits have been reported be upregulated under hypoxic hyperinflammatory conditions. Here, we conducted a prospective cohort...
Background Atherosclerosis is a common comorbidity of obstructive sleep apnoea (OSA) patients, caused by the interaction dyslipidaemia and systemic inflammation. The OSA pro-inflammatory response mediated NLRP3 inflammasome activation, which requires priming signal intermittent hypoxia (IH) an activation provided soluble stimulus present in plasma. Our objectives were to study oxidised low-density lipoprotein (oxLDL) expression patients with or without early subclinical atherosclerosis (eSA)...
COVID-19 has emerged as a devastating disease in the last 2 years. Many authors appointed to importance of kallikrein-kinin system (KKS) pathophysiology it is involved inflammation, vascular homeostasis, and coagulation. We aim study bradykinin cascade its involvement severity patients with COVID-19. This an observational cohort involving 63 consecutive severe pneumonia 27 healthy subjects control group. Clinical laboratory findings plasma protein concentration KKS peptides [bradykinin (BK),...
Aneurysmal subarachnoid hemorrhage (aSAH) is an uncommon and severe subtype of stroke leading to the loss many years productive life. We analyzed NLRP3 activity as well key components inflammasome cascade in monocytes plasma from 28 patients with aSAH 14 normal controls using flow cytometry, western blot, ELISA, qPCR technologies. Our data reveal that present overactivation inflammasome, which results presence high levels interleukin (IL)-1β, IL-18, gasdermin D, tissue factor. Although...
In post-COVID survivors, transforming growth factor-beta-1 (TGF-β1) might mediate fibroblast activation, resulting in persistent fibrosis.
In patients with obstructive sleep apnoea (OSA), intermittent hypoxia induces overexpression of paraspeckle component (PSPC)1, a master modulator transforming growth factor (TGF)-β signalling, which promotes cell cancer progression through epithelial-mesenchymal transition (EMT) and acquisition stem (CSC)-like features. However, the persistence hypoxia-induced effects on PSPC1, their consequences in are not known. To this effect, circulating PSPC1 levels were compared cutaneous melanoma or...
Midkine (MDK) might mediate the proangiogenic effect of intermittent hypoxia (IH) in patients with obstructive sleep apnea (OSA) and cutaneous melanoma (CM). We compare circulating MDK CM without OSA, their relationship tumor aggressiveness, while exploring vitro effects soluble on human lymphatic endothelial (HLEC) cell proliferation. In 360 patients, studies serum level measurements were performed. The proliferation was assessed using HLEC lines patient sera under both normoxia IH. levels...
Obstructive sleep apnea (OSA) has been identified as a cardiovascular (CV) risk factor. The potential of OSA promoting the synthesis CV biomarkers in acute coronary syndrome (ACS) is unknown. Ischemia-modified albumin (IMA) specific biomarker. aim this study was to evaluate role IMA biomarker for determining impact ACS patients. A total 925 patients (15.5% women, age: 59 years, body mass index: 28.8 kg/m2) from ISAACC (NCT01335087) were included. During hospitalization ACS, diagnosis...
Although higher incidence of cancer represents a major burden for obstructive sleep apnea (OSA) patients, the molecular pathways driving this association are not completely understood. Recently, adhesion receptor P-selectin glycoprotein-1 (PSGL 1) has been identified as novel immune checkpoint, which recognized hallmarks in several types and have revolutionized therapy.The expression PSGL-1 its ligands VISTA SIGLEC-5 was assessed leucocytes OSA patients control subjects exploring role...
As some evidence suggests that hypoxia might be an inducer of nuclear paraspeckle formation, we explore whether intermittent (IH)-mediated protein-1 (PSPC1) overexpression contribute to the activation tumor growth factor (TGF)β-SMAD pathway in patients with obstructive sleep apnea (OSA). This would promote changes intracellular signaling explain increased cancer aggressiveness reported these patients. Here, show OSA exhibit elevated PSPC1 levels both plasma and monocytes. Our data suggest is...
Obstructive sleep apnoea (OSA) is associated with several diseases related to metabolic and cardiovascular risk. Although the mechanisms involved in development of these disorders may vary, OSA patients frequently present an increase transforming growth factor beta (TGFβ), activity which higher still hypertension, diabetes or morbidity. Smad4 a member small mother against decapentaplegic homologue (Smad) family signal transducers acts as central mediator TGFβ signalling pathways. In this...
Obstructive sleep apnea (OSA) patients are at special risk of suffering atherosclerosis, leading to major cardiovascular diseases. Notably, the transforming growth factor (TGF-β) plays a crucial role in development and progression atherosclerosis. In this context, central regulator TGF-β pathway, SMAD4 (small mother against decapentaplegic homolog 4), has been previously reported be augmented OSA patients, which levels were even higher with concomitant cardiometabolic Here, we analyzed...
Abstract Active transforming growth factor-β1 (TGF-β1), a cytokine partially regulated by hypoxia and obesity, has been related with poor prognosis in several tumors. We determine whether obstructive sleep apnea (OSA) increases serum levels of active TGF-β1 patients cutaneous melanoma (CM), assess their relationship aggressiveness analyze the factors to obese non-obese OSA patients. In multicenter observational study, 290 CM were underwent studies. was increased moderate-severe vs. non-OSA...