A5066931155- Advancements in Semiconductor Devices and Circuit Design
- Semiconductor materials and devices
- Integrated Circuits and Semiconductor Failure Analysis
- Wireless Power Transfer Systems
- Electrostatic Discharge in Electronics
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Microfluidic and Bio-sensing Technologies
- Inflammasome and immune disorders
- Cancer-related Molecular Pathways
- Electrowetting and Microfluidic Technologies
- Electromagnetic Compatibility and Noise Suppression
- Nanowire Synthesis and Applications
- Energy Harvesting in Wireless Networks
- Cell death mechanisms and regulation
- Meteorological Phenomena and Simulations
- Polydiacetylene-based materials and applications
- Synthesis and properties of polymers
- Toxin Mechanisms and Immunotoxins
- Anodic Oxide Films and Nanostructures
- Veterinary Oncology Research
- Extracellular vesicles in disease
- Phagocytosis and Immune Regulation
- Microstructure and mechanical properties
- Immune Response and Inflammation
Providence University
2024
National Kaohsiung University of Science and Technology
2024
Dalian University of Technology
2023
University of Minnesota Rochester
2023
Providence College
2023
American Society of Echocardiography
2023
Faculty of 1000 (United States)
2023
National Tsing Hua University
1993-2022
National Yang Ming Chiao Tung University
2021-2022
National Taiwan University
2009-2019
The natural killer cell line, NK-92MI, is cytotoxic against various types of cancer. aim this study was to develop chimeric antigen receptor-modified (CAR) NK-92MI cells targeting carcinoembryonic antigen-expressing (CEA) tumours and increase killing efficacy by pharmacologically modifying CEA-expression. We generated anti-CEA-CAR retroviral vector transduction. This genetically-modified line recognised lysed high CEA-expressing tumour lines (LS174T) at 47.54 ± 12.60% moderate (WiDr) 31.14...
A 0.45-V low-power 0.18 μm CMOS OOK/FSK RF receiver for implantable medical applications is proposed. The utilizes a wake-up mechanism to adjust its power consumption automatically by reading the amplitude of input wireless modulated signal directly. No additional commands are required. Such normally-off and instanton scheme reduces this significantly. 129 μW in sleep mode 352 mode. Other techniques, such as third-orderharmonic cancellation, subharmonic mixing, forward body biasing also...
Abstract Microfluidic pump is an essential component in lab-on-chip applications. It of importance to develop active microfluidic with low-power and low-cost characteristics for portable miniaturized diagnostic systems. Taking advantages CMOS technologies, this work, we report a based on travelling-wave electroosmosis (TWEO). Utilizing integrated driving circuit, monolithic can be operated at 1.5 V voltage power consumption 1.74 mW. The circuit consist resistor-capacitor (RC) oscillator,...
The tumor microenvironment is a key determinant for radio-responsiveness. Immune cells play an important role in shaping microenvironments; however, there limited understanding of how natural killer (NK) can enhance radiation effects. This study aimed to assess the mechanism reciprocal complementation and NK on killing. Various cell lines were co-cultured with human primary or line (NK-92) short periods then exposed irradiation. Cell proliferation, apoptosis transwell assays performed...
Abstract In this study, we investigated a fluidic system that adheres to new concepts of energy production. To improve efficiency, cost, and ease manufacture, millimetrically scaled device employs droplet-based co-axial was devised complete alkali-catalyzed transesterification for biodiesel The large surface-to-volume ratio the system, internal circulation induced inside moving droplets, significantly enhanced reaction rate immiscible liquids used here – soybean oil methanol. This also...
Background Apium graveolens L. (celery) is a dietary vegetable with anti-inflammatory properties. It has the potential to treat acute lung injury (ALI) caused by COVID-19 or other diseases.
Interleukin-18 (IL-18) is a pro-inflammatory cytokine involved in the Th1 immune response and expressed by variety of cell types. IL-18 member IL-1 family plays an important role autoimmune diseases inflammation. Using reverse transcriptase-polymerase chain reaction (RT-PCR) mRNA expression IL-18, receptor alpha (IL-18R alpha), beta beta) were studied tumour derived human B-cell lines. Furthermore, we investigated protein secretion using enzyme linked immunosorbent assay (ELISA). The...
A batteryless remotely-controlled locomotive IC utilizing electrolytic bubbles as propelling force is realized in 0.35 μm CMOS technology. Without any external components, such magnets and on-board coils, the bare wirelessly powered controlled by a 10 MHz ASK modulated signal with RS232 control commands to execute movement four moving directions two speeds. The receiving coil electrolysis electrodes are all integrated on chip. experiment successfully demonstrated that moved surface of an...
In this paper, frequency dependency of the Negative Bias Temperature Instability (NBTI) in a wide range (10kHz ~ 500MHz) is investigated using on-chip test structure. The designed structure allows measurement AC and DC mode. Statistically meaningful AC/DC lifetime ratios are extracted after accelerated reliability stress show non-monotonic behavior. Random Telegraph Noise (RTN) trap analysis single defect also carried out which reveals that located near interface with time constant 10 <sup...
Background Drosophila heart tube is a feasible model for cardiac physiological research. However, obtaining electrocardiograms (ECGs) difficult, due to the weak signals and limited contact area apply electrodes. This paper presents non-invasive Gallium-Indium (GaIn) based recording system ECG measurement, providing rate heartbeat features be observed. novel, high-signal-quality prolongs time of insect ECGs, provides platform research on molecular mechanisms involved in cardiovascular...
A micro-controller unit (MCU) assisted immunoassay lab-on-a-chip is realized in 0.35 μm CMOS technology. The MCU automatically controls the detection procedure including blood filtration through a nonporous aluminum oxide membrane, bimolecular conjugation with antibodies attached to magnetic beads, electrolytic pumping, flushing and threshold based on Hall sensor array readout analysis. To verify function of this chip, in-vitro Tumor necrosis factor- α (TNF- α) N-terminal pro-brain...
Conventional time dependent dielectric breakdown (TDDB) test for discrete device usually ties source and drain together, i.e. V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ds</sub> = 0V. However, this condition is seldom seen in a switching logic circuit. To mimic the true behavior of circuit, an inverter-like AC TDDB 64-bit array constructed. Although result not only BTI but also combined effect HCI, it more realistic as well. In paper, we...
A 65 nm node strained SOI technology with high performance is demonstrated, providing drive currents of 1015 and 500 /spl mu/A//spl mu/m for N-FET P-FET, respectively, at an off-state leakage 40 nA//spl using 1 V operation. The employs aggressively scaled slim spacer 30 width to amplify stress benefits improvement, reduce by 10-20 % the layout area SRAM-cell-like circuits, while maintaining excellent hot carrier immunity well-controlled short-channel effects. For first time, we demonstrate...
As implantable medical CMOS devices become a reality [1], motion control of such has the next challenge in advanced integrated micro-system domain. With sensors and controllable propulsion mechanism, will be able to perform tumor scan, drug delivery, neuron stimulation, bio-test, etc, revolutionary way with minimum injury. Such are especially suitable for human hollow organs, as urinary bladder stomach. Motivated by art reported ISSCC 2012 [2], we demonstrate remotely-controlled locomotive...
One of the major purposes evaluating discrete device reliability is to provide aging predictions a circuit. Since ring oscillator (RO) key substitute for fast switching circuits due its simplicity and coverage. It is, therefore, necessary fundamental have an accurate frequency shift simulation RO from based model. (An on model can't be stressed enough.) In this study, correlation between single degradation high-k/metal-gate (HK/MG) discussed. Commonly used I <sub...
Rapid blood test is essential to disease control, risk assessment and point-of-care testing. Conventional enzyme-linked immunosorbent assay (ELISA) requires several hours or even days get meaningful results. However, some fierce contagious diseases, such as Ebola SARS, the contagion can spread so fast that an instant massive screening needed. A CMOS system-on-chip (SoC) offering a cheap tool be very helpful in place where medical resources are limited too costly afford. Unlike previously...
Local radiotherapy (RT) plus intratumoral dendritic cell (DC) injection can mediate immunological response. We hypothesized that co-injection of exogenous recombinant heat shock protein 70 (rHsp70) in combination with RT-DC could be as effective HSP-peptide for evoking specific immune rHsp70-prostate-specific antigen (rHSP70C'-PSA) and α-fetoprotein (rHSP70C'-AFP) were used to compare Growth inhibition the tumor systemic anti-tumor response measured on CT26/PSA CT26/AFP mice model....
Negative Bias Temperature Instability (NBTI) has been one of the major challenges during process development advanced technology. In this paper, NBTI High-k/metal gate (HK/MG) in 10nm FinFET technology evaluated. For first time, fast measurements within sub-microsecond (15ns ~ 1μs) delay time have demonstrated. Such short recovery (delay due to measurement) is achieved through built-in current comparator and a simple state machine. we investigated frequency dependence (10MHz 1GHz) impacts on...
The power-rail electrostatic discharge (ESD) clamp circuits have been widely used in CMOS integrated (ICs) to provide effective discharging paths for on-chip ESD protection design. Among all events, the most serious threat is posed ICs by charged-device model (CDM), as compared with other models. In this work, CDM capability among different was studied and analyzed very-fast transmission line pulse (VF-TLP) measurements are performed at room temperature. combinations of internal together,...
Abstract Granite stone powder is a common type of stone-product industrial waste spreading over Fujian Province and other areas China, causing serious environmental problems. This paper investigates the possibility using granite to completely or partially replace quartz for preparing “Green” “Eco” ultra-high performance concrete under autoclave curing regimes. The mechanical properties microstructure autoclaved ultra-high-performance (UHPC) mixed with different replacement ratios powders...